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- W2790593181 abstract "Abstract The aim of the present study was to develop a fast dissolving film (FDF) of taste masked inclusion complex of Famotidine (FMT) using film forming polymer. FDFs were prepared by solvent casting method applying 32 full factorial design. Response surface methodology (RSM) was used to optimize the independent variables like chitosan as a film forming polymer and PEG-400 as a plasticizer for dependent variable i.e. in vitro drug release (DR).The developed FDFs were characterized for film thickness, disintegration time, FTIR, DSC, XRD, and FESEM analysis.The developed FDFs of FMT were transparent, elegant, smooth and homogenous. Physicochemical characterization of FDFs showed no interaction between the drug and film forming polymer. The drug content was found in the range of 96.05 to 102% and disintegration time was found in pharmacopeial limit, which was less than 1 min. In vitro drug release study showed that approximately 82% drug release within 5 min." @default.
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- W2790593181 date "2018-01-01" @default.
- W2790593181 modified "2023-09-26" @default.
- W2790593181 title "Development and characterization of Fast Dissolving Film of Chitosan embedded Famotidine Using 32 Full Factorial Design Approach" @default.
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- W2790593181 doi "https://doi.org/10.1016/j.matpr.2017.11.099" @default.
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