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• W2790599495 abstract "Abstract Background Amitriptyline has well‐established efficacy in several chronic pain conditions. While optimal treatment for chronic neck pain (CNP) remains controversial, amitriptyline was not tested for CNP. We evaluated the effect of bedtime amitriptyline in the management of CNP. Methods A total of 220 patients suffering from idiopathic CNP were randomized to receive either placebo pill ( n = 108) or 5 mg of amitriptyline ( n = 112) at bedtime for 2 months. Primary outcome measure was visual analog scale (VAS) for pain. Secondary outcome measures were neck pain disability index (NPDI), Bergen Insomnia Score (BIS) and Hospital Anxiety and Depression Scale (HAD), measured before and at the end of 2 months of treatment, with the percentage of patient satisfaction measured at the end of follow‐up only. Results Eight of 112 patients (7.14%) in the amitriptyline group withdrew from the study because of intolerance. Amitriptyline group showed significantly lower VAS scores than placebo group (3.34 ± 1.45 vs. 6.12 ± 0.92; p < 0.0001), which corresponds to a 53.06 ± 20.29% of improvement from baseline pain as compared to 14.41 ± 11.05%, respectively ( p < 0.0001). Similar significant improvements were observed with lesser extents for secondary outcome measures: NPDI, BIS, HAD‐A, HAD‐D and percentage of patient satisfaction. Conclusion Low‐dose amitriptyline is effective for the management of idiopathic CNP with few side effects and high patients’ satisfaction. Significance This randomized controlled trial is the first to show the effectiveness and tolerance of a medication, low‐dose amitriptyline, in managing idiopathic chronic neck pain and its related comorbidities. The optimal treatment of this condition was still controversial in the literature. It extends the indication of low‐dose amitriptyline to another chronic pain condition." @default.
• W2790599495 created "2018-03-29" @default.
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• W2790599495 date "2018-03-09" @default.
• W2790599495 modified "2023-09-27" @default.
• W2790599495 title "Randomized double-blind controlled study of bedtime low-dose amitriptyline in chronic neck pain" @default.
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• W2790599495 doi "https://doi.org/10.1002/ejp.1206" @default.
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