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• W2790604238 abstract "Summary Prolonged isolated thrombocytopenia ( PT ) is a serious complication of allogeneic haematopoietic stem cell transplantation (allo‐ HSCT ). Murine studies and in vitro experiments suggest that mesenchymal stem cells ( MSC s) can, not only to support haematopoiesis, but also preferentially support megakaryocytopoiesis in bone marrow ( BM ). However, little is known about the quantity and function of BM MSC s in PT patients. In a case‐control study, we found that BM MSC s from PT patients exhibited significantly reduced proliferative capacities, increased reactive oxygen species and senescence. Antioxidant (N‐acetyl‐L‐cysteine, NAC ) treatment in vitro not only quantitatively and functionally improved BM MSC s derived from PT patients through down‐regulation of the p38 (also termed MAPK 14) and p53 (also termed TP 53) pathways but also partially rescued the impaired ability of BM MSC s to support megakaryocytopoiesis. Subsequently, a pilot study showed that the overall response of NAC treatment was obtained in 7 of the enrolled PT patients ( N = 10) without significant side effects. Taken together, the results indicated that dysfunctional BM MSC s played a role in the pathogenesis of PT and the impaired BM MSC s could be improved by NAC in vitro . Although requiring further validation, our data indicate that NAC might be a potential therapeutic approach for PT patients after allo‐ HSCT ." @default.
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• W2790604238 date "2018-02-02" @default.
• W2790604238 modified "2023-10-18" @default.
• W2790604238 title "N-acetyl-L-cysteine improves mesenchymal stem cell function in prolonged isolated thrombocytopenia post-allotransplant" @default.
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• W2790604238 doi "https://doi.org/10.1111/bjh.15119" @default.
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