FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2790614908> ?p ?o ?g. }

• W2790614908 endingPage "e0190861" @default.
• W2790614908 startingPage "e0190861" @default.
• W2790614908 abstract "Fibromyalgia (FM) and obesity are closely related. However, little is known about how obesity contributes to FM. Importantly, adequate evidence has shown that tumor necrosis factor alpha (TNF-α) plays a critical role in obesity. Thus, we hypothesized that obesity-induced TNF-α release may potentiate FM-associated pain. To test this hypothesis, we investigated the role of TNF-α in the development of FM-like pain in a mouse model of acid saline injection-induced FM. Consistent with previous reports, we showed that repeated acid saline injections induced bilateral mechanical hyperalgesia, and this effect lasted for at least 4 days after acid saline injections. This phenomenon was associated with increased levels of TNF-α in plasma, muscles, and spinal cord. Furthermore, we found that 24 weeks of high fat diet treatment significantly potentiated acid saline-induced bilateral mechanical hyperalgesia. High fat diet-treated mice exhibited robustly increased levels of TNF-α in plasma, muscles, and spinal cord after acid saline injections compared with low fat diet-treated mice. Additionally, using immunofluorescence staining, we found that the number of TNF-α positive cells in dorsal root ganglion (DRG) was increased after acid saline injections, and high fat diet treatment further sensitized this increase. Finally, we reported that acid saline-induced FM-like pain behaviors were abolished in TNFRp55-/- mice, confirming the critical role of TNF-α in the development of FM-like pain. Taken together, our results suggested that high fat diet treatment may sensitize acid saline-induced FM-like pain via increasing TNF-α levels in plasma, muscles, and DRG." @default.
• W2790614908 created "2018-03-29" @default.
• W2790614908 creator A5064252569 @default.
• W2790614908 creator A5071866732 @default.
• W2790614908 creator A5083283473 @default.
• W2790614908 creator A5083602758 @default.
• W2790614908 creator A5086155499 @default.
• W2790614908 creator A5088670866 @default.
• W2790614908 date "2018-02-14" @default.
• W2790614908 modified "2023-10-14" @default.
• W2790614908 title "High fat diet sensitizes fibromyalgia-like pain behaviors in mice via tumor necrosis factor alpha" @default.
• W2790614908 cites W1514693175 @default.
• W2790614908 cites W1528778201 @default.
• W2790614908 cites W1539805244 @default.
• W2790614908 cites W1554220577 @default.
• W2790614908 cites W1557513385 @default.
• W2790614908 cites W1605764573 @default.
• W2790614908 cites W16582414 @default.
• W2790614908 cites W1750185880 @default.
• W2790614908 cites W18427948 @default.
• W2790614908 cites W1859846440 @default.
• W2790614908 cites W1883044208 @default.
• W2790614908 cites W1965498307 @default.
• W2790614908 cites W1972285257 @default.
• W2790614908 cites W1977788367 @default.
• W2790614908 cites W1978354972 @default.
• W2790614908 cites W1978454776 @default.
• W2790614908 cites W1980722910 @default.
• W2790614908 cites W1982268684 @default.
• W2790614908 cites W1989605721 @default.
• W2790614908 cites W2000492372 @default.
• W2790614908 cites W2015980149 @default.
• W2790614908 cites W2028175059 @default.
• W2790614908 cites W2029278455 @default.
• W2790614908 cites W2031601626 @default.
• W2790614908 cites W2035832718 @default.
• W2790614908 cites W2038765440 @default.
• W2790614908 cites W2039923166 @default.
• W2790614908 cites W2050138902 @default.
• W2790614908 cites W2054704603 @default.
• W2790614908 cites W2061193290 @default.
• W2790614908 cites W2064946902 @default.
• W2790614908 cites W2065034018 @default.
• W2790614908 cites W2068527329 @default.
• W2790614908 cites W2072277653 @default.
• W2790614908 cites W2078071156 @default.
• W2790614908 cites W2080182898 @default.
• W2790614908 cites W2083641769 @default.
• W2790614908 cites W2092744441 @default.
• W2790614908 cites W2100172604 @default.
• W2790614908 cites W2105523906 @default.
• W2790614908 cites W2106785549 @default.
• W2790614908 cites W2111953484 @default.
• W2790614908 cites W2117966992 @default.
• W2790614908 cites W2120480222 @default.
• W2790614908 cites W2128690456 @default.
• W2790614908 cites W2139833921 @default.
• W2790614908 cites W2145925481 @default.
• W2790614908 cites W2147649093 @default.
• W2790614908 cites W2147843893 @default.
• W2790614908 cites W2148575622 @default.
• W2790614908 cites W2150572163 @default.
• W2790614908 cites W2151566924 @default.
• W2790614908 cites W2151975160 @default.
• W2790614908 cites W2160820922 @default.
• W2790614908 cites W2161320464 @default.
• W2790614908 cites W2165844418 @default.
• W2790614908 cites W2169154257 @default.
• W2790614908 cites W2172099267 @default.
• W2790614908 cites W2316282919 @default.
• W2790614908 cites W2402841195 @default.
• W2790614908 cites W2410795380 @default.
• W2790614908 cites W2486670177 @default.
• W2790614908 cites W2571172460 @default.
• W2790614908 cites W2608344749 @default.
• W2790614908 cites W2734359723 @default.
• W2790614908 cites W4250725029 @default.
• W2790614908 doi "https://doi.org/10.1371/journal.pone.0190861" @default.
• W2790614908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5812560" @default.
• W2790614908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29444083" @default.
• W2790614908 hasPublicationYear "2018" @default.
• W2790614908 type Work @default.
• W2790614908 sameAs 2790614908 @default.
• W2790614908 citedByCount "9" @default.
• W2790614908 countsByYear W27906149082018 @default.
• W2790614908 countsByYear W27906149082019 @default.
• W2790614908 countsByYear W27906149082020 @default.
• W2790614908 countsByYear W27906149082021 @default.
• W2790614908 countsByYear W27906149082022 @default.
• W2790614908 crossrefType "journal-article" @default.
• W2790614908 hasAuthorship W2790614908A5064252569 @default.
• W2790614908 hasAuthorship W2790614908A5071866732 @default.
• W2790614908 hasAuthorship W2790614908A5083283473 @default.
• W2790614908 hasAuthorship W2790614908A5083602758 @default.
• W2790614908 hasAuthorship W2790614908A5086155499 @default.
• W2790614908 hasAuthorship W2790614908A5088670866 @default.
• W2790614908 hasBestOaLocation W27906149081 @default.
• W2790614908 hasConcept C118552586 @default.

• next