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- W2790641868 abstract "In September 2011 our departmental protocol for peri-operative prophylactic antibiotic administration was altered from cefuroxime to gentamicin/flucloxacillin, in response to reported links between cephalosporin use and Clostridium difficile (C. diff) infection.As both gentamicin and flucloxacillin are known to be nephrotoxic in some patients, we investigated whether the new regimen increases the risk of Acute Kidney Injury (AKI) in patients undergoing elective and trauma hip and knee surgery, classified by severity (AKI Network criteria). The incidence of C. diff was noted.10 out of 202 (5%) patients receiving cefuroxime (group A) developed AKI, compared with 23 of 210 (11%) patients receiving gentamicin and flucloxacillin (group B) (p=0.012). The severity of the renal injury was higher in the group B patients with 16 sustaining stage II/III AKI, whereas in Group A only one patient sustained a stage II injury and none stage III.The increased AKI rate in group B was observed equally in hip fracture patien..." @default.
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- W2790641868 date "2018-02-21" @default.
- W2790641868 modified "2023-09-27" @default.
- W2790641868 title "PERIOPERATIVE GENTAMICIN/FLUCLOXACILLIN AND ACUTE KIDNEY INJURY IN ORTHOPAEDIC PATIENTS" @default.
- W2790641868 hasPublicationYear "2018" @default.
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