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- W2790643166 abstract "Exercise can improve cognitive function and the outcome of neurodegenerative diseases like Alzheimer’s disease. This effect has been linked to the increased expression of brain-derived neurotrophic factor (BDNF). However, the underlying molecular mechanisms driving the elevation of this neurotrophin remain unknown. Recently, we have reported a PGC-1α-FNDC5/irisin pathway that is activated by exercise in the hippocampus in mice and induces a neuroprotective gene program, including Bdnf. This review will focus on FNDC5 and its secreted form “irisin,” a newly discovered myokine, its role in the nervous system and its therapeutic potential. In addition, we will briefly discuss the role of other exercise-induced myokines in positive brain effects." @default.
- W2790643166 created "2018-03-29" @default.
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- W2790643166 date "2017-01-01" @default.
- W2790643166 modified "2023-10-17" @default.
- W2790643166 title "The Role of FNDC5/Irisin in the Nervous System and as a Mediator for Beneficial Effects of Exercise on the Brain" @default.
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- W2790643166 doi "https://doi.org/10.1007/978-3-319-72790-5_8" @default.
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