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• W2790648116 abstract "Abstract Harmful Algal Blooms (HABs) in freshwater systems and intensified aquaculture have increased the risk to human health through exposure to cyanotoxins such as microcystin-LR (MC-LR). To understand the uptake and processing of MC-LR in humans, the pig was chosen as an animal model. This was assessed by repeated exposure for 13 weeks of eight animals dosed daily with MC-LR at 0.04 µg/kg bw, repeated with six animals over five weeks at a dose 50 times higher at 2 µg/kg bw. An analytical method was developed for MC-LR in porcine serum and also to analyse levels of free MC-LR in harvested porcine tissues, with Lemieux Oxidation employed to determine bound MC-LR in these tissues. MC-LR was not detected in the serum of treated animals from either experiment but free MC-LR was observed in the large intestine and kidney from two animals from the higher dosed group at levels of 1.4 and 1.9 µg/kg dry weight (dw) respectively. The results indicated 50% of higher dosed animals accumulated bound MC-LR in liver tissue, averaging 26.4 µg, approximately 1.1% of the dose administered. These results point to the potential uptake and accumulation of MC-LR in human liver tissue exposed chronically to sub-acute doses." @default.
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• W2790648116 date "2018-03-20" @default.
• W2790648116 modified "2023-10-10" @default.
• W2790648116 title "Uptake and accumulation of Microcystin-LR based on exposure through drinking water: An animal model assessing the human health risk" @default.
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• W2790648116 doi "https://doi.org/10.1038/s41598-018-23312-7" @default.
• W2790648116 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5861052" @default.
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• W2790648116 hasPublicationYear "2018" @default.
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