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• W2790654347 abstract "Muscarinic acetylcholine receptors have been suggested to be implicated in arginine–vasopressin secretion because intracerebroventricular muscarinic agonist administration induces arginine–vasopressin release into the circulation. Although which subtype is involved in the regulation of arginine–vasopressin secretion is unclear, M 2 receptors have been reported to be highly expressed in the hypothalamus. In the present study, M 2 receptor-knockout mice were used to elucidate whether M 2 receptor regulates arginine–vasopressin synthesis in the paraventricular nuclei and supraoptic nuclei of the hypothalamus. The number of arginine–vasopressin-immunoreactive neurons in M 2 receptor-knockout mice was significantly decreased in the supraoptic nuclei, but not in the paraventricular nuclei compared with wild-type mice. Plasma arginine–vasopressin level in M 2 receptor-knockout mice was also significantly lower than in the wild-type mice. Urinary volume and frequency as well as water intake in M 2 receptor-knockout mice were significantly higher than those in wild-type mice. The V 2 vasopressin receptor expression in kidneys of M 2 receptor-knockout mice was comparable with that of wild-type mice, and increased urination in M 2 receptor-knockout mice was significantly decreased by administration of desmopressin, a specific V 2 receptor agonist, suggesting that V 2 receptors in the kidneys of M 2 receptor-knockout mice are intact. These results suggest that M 2 receptors promote arginine–vasopressin synthesis in the supraoptic nuclei and play a role in the regulation and maintenance of body fluid." @default.
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• W2790654347 date "2018-05-01" @default.
• W2790654347 modified "2023-09-23" @default.
• W2790654347 title "Muscarinic M2 receptor promotes vasopressin synthesis in mice supraoptic nuclei" @default.
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• W2790654347 doi "https://doi.org/10.1530/joe-17-0630" @default.
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• W2790654347 hasPublicationYear "2018" @default.
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