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- W2790655276 abstract "GCA is a chronic granulomatous vasculitis that affects large- and medium-sized vessels. Both the innate and the adaptive immune system are thought to play an important role in the initial events of the pathogenesis of GCA. Amplification cascades are involved in the subsequent development and progression of the disease, resulting in vascular inflammation, remodelling and occlusion. The development of large-vessel vasculitis in genetically modified mice has provided some evidence regarding potential mechanisms that lead to vascular inflammation. However, the participation of specific mechanistic pathways in GCA has not been fully established because of the paucity and limitations of functional models. Treatment of GCA is evolving, and novel therapies are being incorporated into the GCA treatment landscape. In addition, to improve the management of GCA, targeted therapies are providing functional proof of concept of the relevance of particular pathogenic mechanisms in the development of GCA and in sustaining vascular inflammation." @default.
- W2790655276 created "2018-03-29" @default.
- W2790655276 creator A5044632715 @default.
- W2790655276 creator A5059764745 @default.
- W2790655276 date "2018-02-01" @default.
- W2790655276 modified "2023-09-23" @default.
- W2790655276 title "Pathogenesis of giant-cell arteritis: how targeted therapies are influencing our understanding of the mechanisms involved" @default.
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- W2790655276 doi "https://doi.org/10.1093/rheumatology/kex423" @default.
- W2790655276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29982777" @default.
- W2790655276 hasPublicationYear "2018" @default.
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