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- W2790689524 abstract "The majority of primary intestinal lymphomas in dogs are T-cell lymphomas, with enteropathy-associated T-cell lymphoma (EATL) large cell type (type 1) being the most common. While most T-cell lymphomas express the T-cell marker CD3, there is increasing evidence that some human and canine T-cell lymphomas coexpress the B-cell marker CD20. We describe 3 cases of CD3+, CD20+, Pax5- EATL type 1 in dogs. All 3 cases had clonal rearrangement of T-cell receptor gamma. Initial clinical signs included weight loss, inappetence, diarrhea, and/or vomiting. The mean age was 9 years (range 3-12). Survival was highly variable ranging from 20 days to longer than 1.6 years. Considering the different chemotherapeutic response of T-cell versus B-cell lymphomas, accurate diagnosis of lymphomas coexpressing CD3 and CD20 as EATL type 1 based on histologic features and clonality results is important. Regardless, the clinical and/or prognostic significance of neoplastic T cells expressing CD20 is unclear." @default.
- W2790689524 created "2018-03-29" @default.
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- W2790689524 date "2018-01-17" @default.
- W2790689524 modified "2023-09-26" @default.
- W2790689524 title "Coexpression of CD3 and CD20 in Canine Enteropathy-Associated T-cell Lymphoma" @default.
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- W2790689524 doi "https://doi.org/10.1177/0300985817747326" @default.
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