FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2790709797> ?p ?o ?g. }

• W2790709797 endingPage "810" @default.
• W2790709797 startingPage "804" @default.
• W2790709797 abstract "HIV-1 reverse transcriptase (RT) in the cytoplasm of HIV-infected cells efficiently inserts the non-canonical dUTP into the proviral DNA, and extends the dU-terminated DNA. The misincorporation of dUTP leads to mutagenesis, and uracils can down-regulate viral gene expression. However, uracilation might also protect HIV DNA from auto-integration in the cytoplasm. Tumor suppressor p53 protein, exhibiting inherent 3'→5' exonuclease activity, provides a potential host-derived repair mechanism during HIV reverse transcription for the misincorporation of various wrong nucleotides, leading to both base-base mismatches and incorporated non-canonical ribonucleotides. Since the presence of proofreading activity is essential for DNA synthesis accuracy, we elucidated the potential involvement of cytoplasmic p53 in the U-editing activities during insertion of dUTP into DNA by recombinant HIV-1 RT (using isogenic p53-proficient and -deficient HCT116 cells). The biochemical data show that p53 in cytoplasm can participate through the intermolecular pathway in a dU-damage-associated repair mechanism by its ability to remove preformed 3'-terminal dUs, thus preventing further extension of 3' dU-terminated primer during DNA synthesis by HIV-1 RT. The specific depletion of p53 from cytoplasmic lysates of repair-proficient p53-harboring cells reduced this negative effect. Accordingly, the increased abundance of p53 in nutlin-treated cells correlates with enhanced error-correction functions, namely, removal of incorporated uracil. The data substantiate the significance of p53 as a potential proofreader for removal of non-canonical dUTP from HIV DNA, thus preventing the consequences of dUTP misincorporation in cell-type specific infectivity of HIV." @default.
• W2790709797 created "2018-03-29" @default.
• W2790709797 creator A5026350408 @default.
• W2790709797 creator A5047702843 @default.
• W2790709797 creator A5049821570 @default.
• W2790709797 creator A5054900639 @default.
• W2790709797 creator A5069849007 @default.
• W2790709797 date "2018-03-01" @default.
• W2790709797 modified "2023-09-23" @default.
• W2790709797 title "Cytoplasmic p53 contributes to the removal of uracils misincorporated by HIV-1 reverse transcriptase" @default.
• W2790709797 cites W1883946154 @default.
• W2790709797 cites W1967072539 @default.
• W2790709797 cites W1975547986 @default.
• W2790709797 cites W1986868099 @default.
• W2790709797 cites W1989791734 @default.
• W2790709797 cites W1998049909 @default.
• W2790709797 cites W2009115701 @default.
• W2790709797 cites W2012463250 @default.
• W2790709797 cites W2026185351 @default.
• W2790709797 cites W2031476529 @default.
• W2790709797 cites W2036270526 @default.
• W2790709797 cites W2043376182 @default.
• W2790709797 cites W2046597315 @default.
• W2790709797 cites W2048098360 @default.
• W2790709797 cites W2056634541 @default.
• W2790709797 cites W2066121768 @default.
• W2790709797 cites W2076879573 @default.
• W2790709797 cites W2077535774 @default.
• W2790709797 cites W2097933346 @default.
• W2790709797 cites W2103585578 @default.
• W2790709797 cites W2129633393 @default.
• W2790709797 cites W2133959309 @default.
• W2790709797 cites W2171105241 @default.
• W2790709797 cites W2315714745 @default.
• W2790709797 cites W2523164178 @default.
• W2790709797 cites W2526091616 @default.
• W2790709797 cites W2558363204 @default.
• W2790709797 cites W2594880325 @default.
• W2790709797 cites W2610882931 @default.
• W2790709797 cites W2742616146 @default.
• W2790709797 cites W4243002328 @default.
• W2790709797 cites W2029504073 @default.
• W2790709797 doi "https://doi.org/10.1016/j.bbrc.2018.02.159" @default.
• W2790709797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29470985" @default.
• W2790709797 hasPublicationYear "2018" @default.
• W2790709797 type Work @default.
• W2790709797 sameAs 2790709797 @default.
• W2790709797 citedByCount "2" @default.
• W2790709797 countsByYear W27907097972019 @default.
• W2790709797 countsByYear W27907097972022 @default.
• W2790709797 crossrefType "journal-article" @default.
• W2790709797 hasAuthorship W2790709797A5026350408 @default.
• W2790709797 hasAuthorship W2790709797A5047702843 @default.
• W2790709797 hasAuthorship W2790709797A5049821570 @default.
• W2790709797 hasAuthorship W2790709797A5054900639 @default.
• W2790709797 hasAuthorship W2790709797A5069849007 @default.
• W2790709797 hasConcept C104317684 @default.
• W2790709797 hasConcept C134935766 @default.
• W2790709797 hasConcept C143425029 @default.
• W2790709797 hasConcept C153911025 @default.
• W2790709797 hasConcept C156719811 @default.
• W2790709797 hasConcept C170748874 @default.
• W2790709797 hasConcept C178790620 @default.
• W2790709797 hasConcept C185592680 @default.
• W2790709797 hasConcept C187206112 @default.
• W2790709797 hasConcept C190062978 @default.
• W2790709797 hasConcept C2756471 @default.
• W2790709797 hasConcept C2777501222 @default.
• W2790709797 hasConcept C2777563447 @default.
• W2790709797 hasConcept C552990157 @default.
• W2790709797 hasConcept C55493867 @default.
• W2790709797 hasConcept C67705224 @default.
• W2790709797 hasConcept C73573662 @default.
• W2790709797 hasConcept C86803240 @default.
• W2790709797 hasConcept C95444343 @default.
• W2790709797 hasConceptScore W2790709797C104317684 @default.
• W2790709797 hasConceptScore W2790709797C134935766 @default.
• W2790709797 hasConceptScore W2790709797C143425029 @default.
• W2790709797 hasConceptScore W2790709797C153911025 @default.
• W2790709797 hasConceptScore W2790709797C156719811 @default.
• W2790709797 hasConceptScore W2790709797C170748874 @default.
• W2790709797 hasConceptScore W2790709797C178790620 @default.
• W2790709797 hasConceptScore W2790709797C185592680 @default.
• W2790709797 hasConceptScore W2790709797C187206112 @default.
• W2790709797 hasConceptScore W2790709797C190062978 @default.
• W2790709797 hasConceptScore W2790709797C2756471 @default.
• W2790709797 hasConceptScore W2790709797C2777501222 @default.
• W2790709797 hasConceptScore W2790709797C2777563447 @default.
• W2790709797 hasConceptScore W2790709797C552990157 @default.
• W2790709797 hasConceptScore W2790709797C55493867 @default.
• W2790709797 hasConceptScore W2790709797C67705224 @default.
• W2790709797 hasConceptScore W2790709797C73573662 @default.
• W2790709797 hasConceptScore W2790709797C86803240 @default.
• W2790709797 hasConceptScore W2790709797C95444343 @default.
• W2790709797 hasIssue "2" @default.
• W2790709797 hasLocation W27907097971 @default.
• W2790709797 hasLocation W27907097972 @default.
• W2790709797 hasOpenAccess W2790709797 @default.

• next