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• W2790711028 endingPage "22" @default.
• W2790711028 startingPage "1" @default.
• W2790711028 abstract "Drug hypersensitivity may manifest ranging from milder skin reactions (e.g., maculopapular exanthema and urticaria) to severe systemic reactions, such as anaphylaxis, drug reactions with eosinophilia and systemic symptoms (DRESS)/drug-induced hypersensitivity syndrome (DIHS), or Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). Current pharmacogenomic studies have made important strides in the prevention of some drug hypersensitivity through the identification of relevant genetic variants, particularly for genes encoding drug-metabolizing enzymes and human leukocyte antigens (HLAs). The associations identified by these studies are usually drug, phenotype, and ethnic specific. The drug presentation models that explain how small drug antigens might interact with HLA and T cell receptor (TCR) molecules in drug hypersensitivity include the hapten theory, the p-i concept, the altered peptide repertoire model, and the altered TCR repertoire model. The broad spectrum of clinical manifestations of drug hypersensitivity involving different drugs, as well as the various pathomechanisms involved, makes the diagnosis and management of it more challenging. This review highlights recent advances in our understanding of the predisposing factors, immune mechanisms, pathogenesis, diagnostic tools, and therapeutic approaches for drug hypersensitivity." @default.
• W2790711028 created "2018-03-29" @default.
• W2790711028 creator A5011719696 @default.
• W2790711028 creator A5043638381 @default.
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• W2790711028 creator A5068882550 @default.
• W2790711028 creator A5073184063 @default.
• W2790711028 date "2018-01-01" @default.
• W2790711028 modified "2023-10-16" @default.
• W2790711028 title "An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity" @default.
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