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- W2790750213 startingPage "250" @default.
- W2790750213 abstract "Many naturally occurring substances, traditionally used in popular medicines around the world, contain the coumarin moiety. Coumarin represents a privileged scaffold for medicinal chemists, because of its peculiar physicochemical features, and the versatile and easy synthetic transformation into a large variety of functionalized coumarins. As a consequence, a huge number of coumarin derivatives have been designed, synthesized, and tested to address many pharmacological targets in a selective way, e.g., selective enzyme inhibitors, and more recently, a number of selected targets (multitarget ligands) involved in multifactorial diseases, such as Alzheimer's and Parkinson's diseases. In this review an overview of the most recent synthetic pathways leading to mono- and polyfunctionalized coumarins will be presented, along with the main biological pathways of their biosynthesis and metabolic transformations. The many existing and recent reviews in the field prompted us to make some drastic selections, and therefore, the review is focused on monoamine oxidase, cholinesterase, and aromatase inhibitors, and on multitarget coumarins acting on selected targets of neurodegenerative diseases." @default.
- W2790750213 created "2018-03-29" @default.
- W2790750213 creator A5024713963 @default.
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- W2790750213 creator A5051548402 @default.
- W2790750213 creator A5056239377 @default.
- W2790750213 creator A5087208103 @default.
- W2790750213 date "2018-01-27" @default.
- W2790750213 modified "2023-10-10" @default.
- W2790750213 title "Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds" @default.
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