FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2790751516> ?p ?o ?g. }

• W2790751516 endingPage "85" @default.
• W2790751516 startingPage "85" @default.
• W2790751516 abstract "Kaposi's sarcoma-associated herpesvirus or Human herpesvirus-8 (KSHV/HHV-8), an oncogenic human herpesvirus and the leading cause of cancer in HIV-infected individuals, is a major public health concern with recurring reports of epidemics on a global level. The early detection of KSHV virus and subsequent activation of the antiviral immune response by the host's immune system are crucial to prevent KSHV infection. The host's immune system is an evolutionary conserved system that provides the most important line of defense against invading microbial pathogens, including viruses. Viruses are initially detected by the cells of the host innate immune system, which evoke concerted antiviral responses via the secretion of interferons (IFNs) and inflammatory cytokines/chemokines for elimination of the invaders. Type I IFN and cytokine gene expression are regulated by multiple intracellular signaling pathways that are activated by germline-encoded host sensors, i.e., pattern recognition receptors (PRRs) that recognize a conserved set of ligands, known as 'pathogen-associated molecular patterns (PAMPs)'. On the contrary, persistent and dysregulated signaling of PRRs promotes numerous tumor-causing inflammatory events in various human cancers. Being an integral component of the mammalian innate immune response and due to their constitutive activation in tumor cells, targeting PRRs appears to be an effective strategy for tumor prevention and/or treatment. Cellular PRRs are known to respond to KSHV infection, and KSHV has been shown to be armed with an array of strategies to selectively inhibit cellular PRR-based immune sensing to its benefit. In particular, KSHV has acquired specific immunomodulatory genes to effectively subvert PRR responses during the early stages of primary infection, lytic reactivation and latency, for a successful establishment of a life-long persistent infection. The current review aims to comprehensively summarize the latest advances in our knowledge of role of PRRs in KSHV infections." @default.
• W2790751516 created "2018-03-29" @default.
• W2790751516 creator A5039637801 @default.
• W2790751516 creator A5045097382 @default.
• W2790751516 creator A5058879648 @default.
• W2790751516 creator A5091903756 @default.
• W2790751516 date "2018-03-20" @default.
• W2790751516 modified "2023-10-10" @default.
• W2790751516 title "Role of Pattern Recognition Receptors in KSHV Infection" @default.
• W2790751516 cites W109913499 @default.
• W2790751516 cites W135187131 @default.
• W2790751516 cites W1481548475 @default.
• W2790751516 cites W1491026704 @default.
• W2790751516 cites W1503420509 @default.
• W2790751516 cites W1529674879 @default.
• W2790751516 cites W1559117436 @default.
• W2790751516 cites W1604210388 @default.
• W2790751516 cites W1673747382 @default.
• W2790751516 cites W1673837423 @default.
• W2790751516 cites W1767534568 @default.
• W2790751516 cites W1776384951 @default.
• W2790751516 cites W1786790919 @default.
• W2790751516 cites W180388877 @default.
• W2790751516 cites W1826650884 @default.
• W2790751516 cites W1860224105 @default.
• W2790751516 cites W1912241317 @default.
• W2790751516 cites W1965634572 @default.
• W2790751516 cites W1965658052 @default.
• W2790751516 cites W1968258480 @default.
• W2790751516 cites W1969555540 @default.
• W2790751516 cites W1972162753 @default.
• W2790751516 cites W1972167991 @default.
• W2790751516 cites W1973621084 @default.
• W2790751516 cites W1975656765 @default.
• W2790751516 cites W1976641138 @default.
• W2790751516 cites W1977500292 @default.
• W2790751516 cites W1978210814 @default.
• W2790751516 cites W1978468923 @default.
• W2790751516 cites W1980749674 @default.
• W2790751516 cites W1982535405 @default.
• W2790751516 cites W1982677586 @default.
• W2790751516 cites W1985329774 @default.
• W2790751516 cites W1985970823 @default.
• W2790751516 cites W1988429312 @default.
• W2790751516 cites W1990301855 @default.
• W2790751516 cites W1991982546 @default.
• W2790751516 cites W1993122793 @default.
• W2790751516 cites W1995744610 @default.
• W2790751516 cites W1995912453 @default.
• W2790751516 cites W1996398553 @default.
• W2790751516 cites W1999910275 @default.
• W2790751516 cites W2004465286 @default.
• W2790751516 cites W2004516435 @default.
• W2790751516 cites W2007430725 @default.
• W2790751516 cites W2009708031 @default.
• W2790751516 cites W2009834812 @default.
• W2790751516 cites W2010800481 @default.
• W2790751516 cites W2011176464 @default.
• W2790751516 cites W2011753823 @default.
• W2790751516 cites W2016194523 @default.
• W2790751516 cites W2017469353 @default.
• W2790751516 cites W2017658660 @default.
• W2790751516 cites W2018828712 @default.
• W2790751516 cites W2019745410 @default.
• W2790751516 cites W2020969008 @default.
• W2790751516 cites W2021230504 @default.
• W2790751516 cites W2024185937 @default.
• W2790751516 cites W2025084043 @default.
• W2790751516 cites W2025343024 @default.
• W2790751516 cites W2027587005 @default.
• W2790751516 cites W2027931900 @default.
• W2790751516 cites W2028671942 @default.
• W2790751516 cites W2028792773 @default.
• W2790751516 cites W2029650318 @default.
• W2790751516 cites W2030744918 @default.
• W2790751516 cites W2032438721 @default.
• W2790751516 cites W2032566972 @default.
• W2790751516 cites W2034269086 @default.
• W2790751516 cites W2034277378 @default.
• W2790751516 cites W2035809809 @default.
• W2790751516 cites W2037580272 @default.
• W2790751516 cites W2038603612 @default.
• W2790751516 cites W2039268906 @default.
• W2790751516 cites W2039745983 @default.
• W2790751516 cites W2039851322 @default.
• W2790751516 cites W2040049401 @default.
• W2790751516 cites W2040675530 @default.
• W2790751516 cites W2042158880 @default.
• W2790751516 cites W2042433863 @default.
• W2790751516 cites W2046948354 @default.
• W2790751516 cites W2047064244 @default.
• W2790751516 cites W2047194051 @default.
• W2790751516 cites W2048660375 @default.
• W2790751516 cites W2049400800 @default.
• W2790751516 cites W2053665358 @default.
• W2790751516 cites W2057093537 @default.
• W2790751516 cites W2058213975 @default.
• W2790751516 cites W2060537202 @default.

• next