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• W2790753526 abstract "Aims Mounting evidence indicates that a variety of factors released from the urothelium or suburothelium can modulate smooth muscle activity. Although the relationship between the mucosa and smooth muscle has been investigated, little is known about the pathophysiologic changes in detrusor‐mucosa interactions in neurogenic bladders. The goal of the study was to determine the impact of the mucosa on evoked responses in spinal cord injured (SCI) bladders. Methods Urinary bladders were obtained from 6wk SCI rats or age‐matched uninjured controls. Ex vivo isometric tension studies were performed and muscarinic receptor expression was measured in bladder tissue with and without mucosa. Results The magnitude and area of nerve evoked responses in SCI tissue with mucosa was higher than without mucosa. The duration and decay time of nerve‐evoked responses were longer in SCI than control tissue irrespective of the mucosa. The level of the muscarinic M 2 receptor was decreased in the mucosa of SCI bladders. Conclusions Detrusor‐mucosa interactions are substantially altered in the neurogenic bladder. After spinal cord injury, an excitatory modulation of smooth muscle contraction by the mucosa emerges, and could be targeted via intravesical treatment in the context of neurogenic bladder dysfunction." @default.
• W2790753526 created "2018-03-29" @default.
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• W2790753526 date "2018-02-10" @default.
• W2790753526 modified "2023-09-26" @default.
• W2790753526 title "The role of the mucosa in modulation of evoked responses in the spinal cord injured rat bladder" @default.
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• W2790753526 doi "https://doi.org/10.1002/nau.23512" @default.
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