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- W2790758834 abstract "Human health is complex and multifaceted; there is a need for biomarkers that reflect the multidimensional nature of health.To identify potential epigenomic biomarkers of health in women aged 18-40 participating in a six-month lifestyle intervention, next level health.Methylation data were obtained by reduced representation bisulphite sequencing of 21 female intervention participants as well as three non-participants. The Differential Methylation Analysis Package (DMAP) was used to investigate inter- and intra-individual variability and to identify potential targets of transient epigenetic control in the population studied.Eleven genes were identified as significantly differentially methylated post- intervention in all 21 participants. 1884 genomic locations were found to be differentially methylated amongst the total female population studied representing potential epigenomic biomarkers.The ability to demonstrate epigenetic changes arising from a lifestyle intervention can provide key information on the relationship between gene regulation, human behaviour and health." @default.
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- W2790758834 date "2018-03-02" @default.
- W2790758834 modified "2023-09-23" @default.
- W2790758834 title "Identification of potential ‘lifestyle-responsive’ epigenomic biomarkers in healthy women aged 18–40" @default.
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- W2790758834 doi "https://doi.org/10.1080/1354750x.2018.1443512" @default.
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