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- W2790759894 abstract "The pathophysiology of drug-resistant pediatric epilepsy is unknown. Flow cytometric analysis of inflammatory leukocytes in resected brain tissues from 29 pediatric patients with genetic (focal cortical dysplasia) or acquired (encephalomalacia) epilepsy demonstrated significant brain infiltration of blood-borne inflammatory myeloid cells and memory CD4+ and CD8+ T cells. Significantly, proinflammatory (IL-17- and GM-CSF-producing) γδ T cells were concentrated in epileptogenic lesions, and their numbers positively correlated with disease severity. Conversely, numbers of regulatory T (T reg) cells inversely correlated with disease severity. Correspondingly, using the kainic acid model of status epilepticus, we show ameliorated seizure activity in both γδ T cell- and IL-17RA-deficient mice and in recipients of T reg cells, whereas T reg cell depletion heightened seizure severity. Moreover, both IL-17 and GM-CSF induced neuronal hyperexcitability in brain slice cultures. These studies support a major pathological role for peripherally derived innate and adaptive proinflammatory immune responses in the pathogenesis of intractable epilepsy and suggest testing of immunomodulatory therapies." @default.
- W2790759894 created "2018-03-29" @default.
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- W2790759894 date "2018-02-27" @default.
- W2790759894 modified "2023-10-17" @default.
- W2790759894 title "Peripherally derived T regulatory and γδ T cells have opposing roles in the pathogenesis of intractable pediatric epilepsy" @default.
- W2790759894 cites W127248092 @default.
- W2790759894 cites W1504746607 @default.
- W2790759894 cites W1517021132 @default.
- W2790759894 cites W1544884210 @default.
- W2790759894 cites W1569732784 @default.
- W2790759894 cites W1647734909 @default.
- W2790759894 cites W1700278844 @default.
- W2790759894 cites W1771974095 @default.
- W2790759894 cites W1853959720 @default.
- W2790759894 cites W1920696238 @default.
- W2790759894 cites W1921268863 @default.
- W2790759894 cites W1965439640 @default.
- W2790759894 cites W1971728959 @default.
- W2790759894 cites W1974809694 @default.
- W2790759894 cites W1977291679 @default.
- W2790759894 cites W1980555514 @default.
- W2790759894 cites W1981688486 @default.
- W2790759894 cites W1983100194 @default.
- W2790759894 cites W1991535283 @default.
- W2790759894 cites W1994612125 @default.
- W2790759894 cites W1996189984 @default.
- W2790759894 cites W2009495078 @default.
- W2790759894 cites W2010003461 @default.
- W2790759894 cites W2014484839 @default.
- W2790759894 cites W2014778415 @default.
- W2790759894 cites W2016471860 @default.
- W2790759894 cites W2016854448 @default.
- W2790759894 cites W2020043117 @default.
- W2790759894 cites W2022981588 @default.
- W2790759894 cites W2029269629 @default.
- W2790759894 cites W2031120775 @default.
- W2790759894 cites W2041525670 @default.
- W2790759894 cites W2043919941 @default.
- W2790759894 cites W2047243927 @default.
- W2790759894 cites W2048956484 @default.
- W2790759894 cites W2050661112 @default.
- W2790759894 cites W2050866724 @default.
- W2790759894 cites W2053219721 @default.
- W2790759894 cites W2056209646 @default.
- W2790759894 cites W2058981488 @default.
- W2790759894 cites W2062098209 @default.
- W2790759894 cites W2066521804 @default.
- W2790759894 cites W2073427034 @default.
- W2790759894 cites W2081656058 @default.
- W2790759894 cites W2082937428 @default.
- W2790759894 cites W2089491243 @default.
- W2790759894 cites W2092149834 @default.
- W2790759894 cites W2093070846 @default.
- W2790759894 cites W2102314363 @default.
- W2790759894 cites W2105838733 @default.
- W2790759894 cites W2106105150 @default.
- W2790759894 cites W2107406740 @default.
- W2790759894 cites W2108170307 @default.
- W2790759894 cites W2109606712 @default.
- W2790759894 cites W2117360135 @default.
- W2790759894 cites W2117378831 @default.
- W2790759894 cites W2122632726 @default.
- W2790759894 cites W2124416664 @default.
- W2790759894 cites W2127126677 @default.
- W2790759894 cites W2128463839 @default.
- W2790759894 cites W2131362389 @default.
- W2790759894 cites W2141120827 @default.
- W2790759894 cites W2149846553 @default.
- W2790759894 cites W2149915530 @default.
- W2790759894 cites W2150047376 @default.
- W2790759894 cites W2151323473 @default.
- W2790759894 cites W2159712156 @default.
- W2790759894 cites W2161140483 @default.
- W2790759894 cites W2162520826 @default.
- W2790759894 cites W2188421788 @default.
- W2790759894 cites W2192584681 @default.
- W2790759894 cites W2199795619 @default.
- W2790759894 cites W2214989086 @default.
- W2790759894 cites W2280077905 @default.
- W2790759894 cites W2304532897 @default.
- W2790759894 cites W2413821580 @default.
- W2790759894 cites W2415723108 @default.
- W2790759894 cites W2477557851 @default.
- W2790759894 cites W2695091068 @default.
- W2790759894 cites W3169952815 @default.