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- W2790759916 abstract "Significance Rhythms in gene expression propelled by the circadian clock and environmental signals are ubiquitous across cells and tissues. In particular, in mouse tissues, thousands of transcripts show oscillations with a period of 24 hours. Keys question are how such rhythms propagate and eventually exert functions, but also how these are generated. Here, we developed a mathematical model based on total RNA-seq to classify genes according to the respective contributions of transcriptional and posttranscriptional regulation toward mRNA expression profiles. We found that about one-third of rhythmically accumulating mRNA are under posttranscriptional regulation. Such regulation is only partially dependent on the circadian clock, showing that systemic pathways and feeding patterns contribute important posttranscriptional control of gene expression in liver." @default.
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- W2790759916 date "2018-02-05" @default.
- W2790759916 modified "2023-10-13" @default.
- W2790759916 title "Circadian clock-dependent and -independent posttranscriptional regulation underlies temporal mRNA accumulation in mouse liver" @default.
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- W2790759916 doi "https://doi.org/10.1073/pnas.1715225115" @default.
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