Matches in SemOpenAlex for { <https://semopenalex.org/work/W2790839875> ?p ?o ?g. }
- W2790839875 endingPage "802" @default.
- W2790839875 startingPage "794" @default.
- W2790839875 abstract "Interleukin 17 (IL-17) is an important cytokine that can induce tissue inflammation and is involved in the pathogenesis of numerous autoimmune diseases. However, the regulation of its signaling transduction has not been well described. In this study, we report that thousand and one kinase 1 (TAOK1) functions as a negative regulator of IL-17-mediated signal transduction and inflammation. TAOK1 knockdown promotes IL-17-induced cytokine and chemokine expression and the activation of mitogen-activated protein kinases and nuclear factor-κB. We further demonstrate that TAOK1 interacts with IL-17 receptor A (IL-17RA) independent of its kinase activity, and TAOK1 dose-dependently prevents the formation of the IL-17R-Act1 (nuclear factor activator 1, also known as tumor necrosis factor receptor-associated factor 3 interacting protein 2) complex. Consistent with this, TAOK1 deficiency exacerbates colitis in the 2,4,6-trinitrobenzenesulfonic acid)-induced experimental model of inflammatory bowel disease, likely by its promotion of the IL-17-mediated signaling pathway. TAOK1 expression is decreased in the colons of ulcerative colitis patients. In conclusion, these findings suggest that TAOK1 is involved in the development of IL-17-related autoimmune disorders." @default.
- W2790839875 created "2018-03-29" @default.
- W2790839875 creator A5002032950 @default.
- W2790839875 creator A5005605092 @default.
- W2790839875 creator A5015913024 @default.
- W2790839875 creator A5019257366 @default.
- W2790839875 creator A5029205668 @default.
- W2790839875 creator A5029782003 @default.
- W2790839875 creator A5044406290 @default.
- W2790839875 creator A5068038230 @default.
- W2790839875 creator A5079549927 @default.
- W2790839875 creator A5085266820 @default.
- W2790839875 date "2018-02-05" @default.
- W2790839875 modified "2023-10-16" @default.
- W2790839875 title "TAOK1 negatively regulates IL-17-mediated signaling and inflammation" @default.
- W2790839875 cites W1964091691 @default.
- W2790839875 cites W2003904938 @default.
- W2790839875 cites W2004193943 @default.
- W2790839875 cites W2006711580 @default.
- W2790839875 cites W2020233428 @default.
- W2790839875 cites W2021674244 @default.
- W2790839875 cites W2024595613 @default.
- W2790839875 cites W2024934120 @default.
- W2790839875 cites W2045905604 @default.
- W2790839875 cites W2049651125 @default.
- W2790839875 cites W2060500374 @default.
- W2790839875 cites W2061538653 @default.
- W2790839875 cites W2062637050 @default.
- W2790839875 cites W2065136791 @default.
- W2790839875 cites W2070715537 @default.
- W2790839875 cites W2073203830 @default.
- W2790839875 cites W2085187432 @default.
- W2790839875 cites W2092128105 @default.
- W2790839875 cites W2093897672 @default.
- W2790839875 cites W2109666345 @default.
- W2790839875 cites W2119763611 @default.
- W2790839875 cites W2145468317 @default.
- W2790839875 cites W2148515049 @default.
- W2790839875 cites W2155989572 @default.
- W2790839875 cites W2160247072 @default.
- W2790839875 cites W2167107736 @default.
- W2790839875 cites W2256155471 @default.
- W2790839875 cites W2310017168 @default.
- W2790839875 cites W2316247155 @default.
- W2790839875 cites W2507937615 @default.
- W2790839875 cites W2509680513 @default.
- W2790839875 cites W2557275216 @default.
- W2790839875 cites W2589236405 @default.
- W2790839875 cites W2734717940 @default.
- W2790839875 cites W31124784 @default.
- W2790839875 cites W877749407 @default.
- W2790839875 doi "https://doi.org/10.1038/cmi.2017.158" @default.
- W2790839875 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6141603" @default.
- W2790839875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29400705" @default.
- W2790839875 hasPublicationYear "2018" @default.
- W2790839875 type Work @default.
- W2790839875 sameAs 2790839875 @default.
- W2790839875 citedByCount "31" @default.
- W2790839875 countsByYear W27908398752018 @default.
- W2790839875 countsByYear W27908398752019 @default.
- W2790839875 countsByYear W27908398752020 @default.
- W2790839875 countsByYear W27908398752021 @default.
- W2790839875 countsByYear W27908398752022 @default.
- W2790839875 countsByYear W27908398752023 @default.
- W2790839875 crossrefType "journal-article" @default.
- W2790839875 hasAuthorship W2790839875A5002032950 @default.
- W2790839875 hasAuthorship W2790839875A5005605092 @default.
- W2790839875 hasAuthorship W2790839875A5015913024 @default.
- W2790839875 hasAuthorship W2790839875A5019257366 @default.
- W2790839875 hasAuthorship W2790839875A5029205668 @default.
- W2790839875 hasAuthorship W2790839875A5029782003 @default.
- W2790839875 hasAuthorship W2790839875A5044406290 @default.
- W2790839875 hasAuthorship W2790839875A5068038230 @default.
- W2790839875 hasAuthorship W2790839875A5079549927 @default.
- W2790839875 hasAuthorship W2790839875A5085266820 @default.
- W2790839875 hasBestOaLocation W27908398751 @default.
- W2790839875 hasConcept C13373296 @default.
- W2790839875 hasConcept C17991360 @default.
- W2790839875 hasConcept C184235292 @default.
- W2790839875 hasConcept C203014093 @default.
- W2790839875 hasConcept C2775855021 @default.
- W2790839875 hasConcept C2776914184 @default.
- W2790839875 hasConcept C2778690821 @default.
- W2790839875 hasConcept C502942594 @default.
- W2790839875 hasConcept C62478195 @default.
- W2790839875 hasConcept C86803240 @default.
- W2790839875 hasConcept C95444343 @default.
- W2790839875 hasConceptScore W2790839875C13373296 @default.
- W2790839875 hasConceptScore W2790839875C17991360 @default.
- W2790839875 hasConceptScore W2790839875C184235292 @default.
- W2790839875 hasConceptScore W2790839875C203014093 @default.
- W2790839875 hasConceptScore W2790839875C2775855021 @default.
- W2790839875 hasConceptScore W2790839875C2776914184 @default.
- W2790839875 hasConceptScore W2790839875C2778690821 @default.
- W2790839875 hasConceptScore W2790839875C502942594 @default.
- W2790839875 hasConceptScore W2790839875C62478195 @default.
- W2790839875 hasConceptScore W2790839875C86803240 @default.
- W2790839875 hasConceptScore W2790839875C95444343 @default.