FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2790869627> ?p ?o ?g. }

• W2790869627 endingPage "4407" @default.
• W2790869627 startingPage "4398" @default.
• W2790869627 abstract "In rat sperm heads, sphingomyelin (SM) species that contain very long-chain polyunsaturated fatty acid (V-SM) become ceramides (V-Cer) after inducing in vitro the acrosomal reaction. The reason for such a specific location of this conversion, catalyzed by a sphingomyelinase (SMase), has received little investigation so far. Here, the effects of SMase were compared in unilamellar vesicles (large unilamellar vesicles (LUVs), giant unilamellar vesicles (GUVs)) containing phosphatidylcholine, and either V-SM or a palmitate-rich SM (P-SM). In uniformly sized LUVs at 37 °C, more V-Cer was generated and more rapidly than P-Cer. Nephelometry and dynamic light scattering showed that LUVs tended to form large lipid particles more intensely, and Förster resonance energy transfer (FRET) increases suggested that lateral lipid mixing was more marked when V-Cer rather than P-Cer was produced. As reported by 6-dodecanoyl-2-dimethyl-aminopnaphthalene (Laurdan) and 1,6-diphenyl-1,3,5,-hexatriene (DPH), the production of V-Cer resulted in higher and faster restriction in lipid mobility than that of P-Cer, implying a stronger increase in membrane dehydration and microviscosity. Moreover, DPH anisotropy suggested a higher solubility of V-Cer than that of P-Cer in the liquid-disordered phase. At room temperature, liquid-condensed lateral domains appeared in P-SM- but not in V-SM-containing GUVs. The former maintained their size while losing their contents gradually during SMase action, whereas the latter became permeable earlier and reduced their size in few minutes until suddenly collapsing. The fast and potent generation of V-Cer may contribute to the membrane restructuring events that occur on the acrosome-reacted sperm head." @default.
• W2790869627 created "2018-03-29" @default.
• W2790869627 creator A5039861070 @default.
• W2790869627 creator A5075534035 @default.
• W2790869627 creator A5079635755 @default.
• W2790869627 creator A5090250392 @default.
• W2790869627 creator A5083861715 @default.
• W2790869627 date "2018-03-15" @default.
• W2790869627 modified "2023-10-12" @default.
• W2790869627 title "Membrane Restructuring Events during the Enzymatic Generation of Ceramides with Very Long-Chain Polyunsaturated Fatty Acids" @default.
• W2790869627 cites W1513615071 @default.
• W2790869627 cites W1937590177 @default.
• W2790869627 cites W1963836338 @default.
• W2790869627 cites W1963935193 @default.
• W2790869627 cites W1969751702 @default.
• W2790869627 cites W1990658611 @default.
• W2790869627 cites W1990700312 @default.
• W2790869627 cites W1999212398 @default.
• W2790869627 cites W1999698653 @default.
• W2790869627 cites W2004897610 @default.
• W2790869627 cites W2006611514 @default.
• W2790869627 cites W2012693613 @default.
• W2790869627 cites W2014620395 @default.
• W2790869627 cites W2022793196 @default.
• W2790869627 cites W2028434936 @default.
• W2790869627 cites W2032984448 @default.
• W2790869627 cites W2041843835 @default.
• W2790869627 cites W2045441299 @default.
• W2790869627 cites W2047840022 @default.
• W2790869627 cites W2051783142 @default.
• W2790869627 cites W2051909813 @default.
• W2790869627 cites W2052938737 @default.
• W2790869627 cites W2062367732 @default.
• W2790869627 cites W2066594184 @default.
• W2790869627 cites W2085223381 @default.
• W2790869627 cites W2085246663 @default.
• W2790869627 cites W2087793146 @default.
• W2790869627 cites W2104477642 @default.
• W2790869627 cites W2133991651 @default.
• W2790869627 cites W2147669099 @default.
• W2790869627 cites W2168073971 @default.
• W2790869627 cites W2168379147 @default.
• W2790869627 cites W2180378845 @default.
• W2790869627 cites W2237164154 @default.
• W2790869627 cites W2320060908 @default.
• W2790869627 cites W2336565533 @default.
• W2790869627 cites W2529004096 @default.
• W2790869627 cites W4239596662 @default.
• W2790869627 doi "https://doi.org/10.1021/acs.langmuir.7b04374" @default.
• W2790869627 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29540057" @default.
• W2790869627 hasPublicationYear "2018" @default.
• W2790869627 type Work @default.
• W2790869627 sameAs 2790869627 @default.
• W2790869627 citedByCount "5" @default.
• W2790869627 countsByYear W27908696272020 @default.
• W2790869627 countsByYear W27908696272022 @default.
• W2790869627 countsByYear W27908696272023 @default.
• W2790869627 crossrefType "journal-article" @default.
• W2790869627 hasAuthorship W2790869627A5039861070 @default.
• W2790869627 hasAuthorship W2790869627A5075534035 @default.
• W2790869627 hasAuthorship W2790869627A5079635755 @default.
• W2790869627 hasAuthorship W2790869627A5083861715 @default.
• W2790869627 hasAuthorship W2790869627A5090250392 @default.
• W2790869627 hasConcept C12554922 @default.
• W2790869627 hasConcept C130316041 @default.
• W2790869627 hasConcept C139932579 @default.
• W2790869627 hasConcept C185592680 @default.
• W2790869627 hasConcept C190283241 @default.
• W2790869627 hasConcept C2776330855 @default.
• W2790869627 hasConcept C2777851122 @default.
• W2790869627 hasConcept C2778390148 @default.
• W2790869627 hasConcept C2778918659 @default.
• W2790869627 hasConcept C2780943371 @default.
• W2790869627 hasConcept C2781070647 @default.
• W2790869627 hasConcept C41625074 @default.
• W2790869627 hasConcept C43617362 @default.
• W2790869627 hasConcept C55493867 @default.
• W2790869627 hasConcept C61322309 @default.
• W2790869627 hasConcept C86803240 @default.
• W2790869627 hasConceptScore W2790869627C12554922 @default.
• W2790869627 hasConceptScore W2790869627C130316041 @default.
• W2790869627 hasConceptScore W2790869627C139932579 @default.
• W2790869627 hasConceptScore W2790869627C185592680 @default.
• W2790869627 hasConceptScore W2790869627C190283241 @default.
• W2790869627 hasConceptScore W2790869627C2776330855 @default.
• W2790869627 hasConceptScore W2790869627C2777851122 @default.
• W2790869627 hasConceptScore W2790869627C2778390148 @default.
• W2790869627 hasConceptScore W2790869627C2778918659 @default.
• W2790869627 hasConceptScore W2790869627C2780943371 @default.
• W2790869627 hasConceptScore W2790869627C2781070647 @default.
• W2790869627 hasConceptScore W2790869627C41625074 @default.
• W2790869627 hasConceptScore W2790869627C43617362 @default.
• W2790869627 hasConceptScore W2790869627C55493867 @default.
• W2790869627 hasConceptScore W2790869627C61322309 @default.
• W2790869627 hasConceptScore W2790869627C86803240 @default.
• W2790869627 hasFunder F4320312064 @default.
• W2790869627 hasFunder F4320321594 @default.
• W2790869627 hasFunder F4320337954 @default.

• next