FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2790906215> ?p ?o ?g. }

• W2790906215 abstract "Abstract Aim Cortistatin ( CST ) is a newly discovered endogenous active peptide that exerts protective effects on the cardiovascular system. However, the relationship between CST and aortic calcification and the underlying mechanism remain obscure. Therefore, we investigated effects of CST on aortic calcification and its signalling pathways. Methods Calcium content and alkaline phosphatase ( ALP ) activity were measured using the o‐cresolphthalein colorimetric method and ALP assay kit respectively. Protein expression of smooth muscle ( SM )‐ɑ‐actin, osteocalcin ( OCN ), β‐catenin, glycogen synthase kinase 3β ( GSK 3β), p‐ GSK 3β, protein kinase C ( PKC ), p‐ PKC , c‐Jun N‐terminal kinase ( JNK ) and p‐ JNK was determined using Western blotting. Results In aorta from a rat vitamin D3 calcification model, CST abrogated calcium deposition and pathological damage, decreased the protein expression of OCN and β‐catenin and increased SM ‐ɑ‐actin expression. In a rat cultured vascular smooth muscular cell ( VSMC ) calcification model induced by β‐glycerophosphate (β‐ GP ), CST inhibited the increase in ALP activity, calcium content and OCN protein and the decrease in SM ‐α‐actin expression. CST also inhibited the β‐ GP ‐induced increase in p‐ GSK 3β and β‐catenin protein (both P < .05). The inhibitory effects of CST on ALP activity, calcium deposition and β‐catenin protein were abolished by pretreatment with lithium chloride, a GSK 3β inhibitor. CST promoted the protein expression of p‐ PKC by 68.5% ( P < .01), but not p‐ JNK . The ability of CST to attenuate β‐ GP ‐induced increase in ALP activity, calcium content and OCN expression in the VSMC model was abolished by pretreatment with the PKC inhibitor Go6976. Conclusion These results indicate that CST inhibits aortic calcification and osteogenic differentiation of VSMC s likely via the GSK 3β/β‐catenin and PKC signalling pathways, but not JNK signalling pathway." @default.
• W2790906215 created "2018-03-29" @default.
• W2790906215 creator A5003085792 @default.
• W2790906215 creator A5012272007 @default.
• W2790906215 creator A5019251501 @default.
• W2790906215 creator A5037172649 @default.
• W2790906215 creator A5039629749 @default.
• W2790906215 creator A5063531555 @default.
• W2790906215 creator A5089336085 @default.
• W2790906215 creator A5091620323 @default.
• W2790906215 date "2018-03-08" @default.
• W2790906215 modified "2023-10-06" @default.
• W2790906215 title "Cortistatin inhibits arterial calcification in rats via GSK3β/β-catenin and protein kinase C signalling but not c-Jun N-terminal kinase signalling" @default.
• W2790906215 cites W1899440446 @default.
• W2790906215 cites W1972060990 @default.
• W2790906215 cites W1973895552 @default.
• W2790906215 cites W1975700889 @default.
• W2790906215 cites W1979055405 @default.
• W2790906215 cites W1985945376 @default.
• W2790906215 cites W1987742077 @default.
• W2790906215 cites W1989382448 @default.
• W2790906215 cites W1993841019 @default.
• W2790906215 cites W1994105038 @default.
• W2790906215 cites W1996016792 @default.
• W2790906215 cites W1999069103 @default.
• W2790906215 cites W2003188808 @default.
• W2790906215 cites W2012390518 @default.
• W2790906215 cites W2014889568 @default.
• W2790906215 cites W2015248458 @default.
• W2790906215 cites W2016594385 @default.
• W2790906215 cites W2026540040 @default.
• W2790906215 cites W2042382592 @default.
• W2790906215 cites W2047290165 @default.
• W2790906215 cites W2047992631 @default.
• W2790906215 cites W2049266367 @default.
• W2790906215 cites W2069353566 @default.
• W2790906215 cites W2080961942 @default.
• W2790906215 cites W2085627947 @default.
• W2790906215 cites W2118835331 @default.
• W2790906215 cites W2123001308 @default.
• W2790906215 cites W2126027102 @default.
• W2790906215 cites W2130463080 @default.
• W2790906215 cites W2135321183 @default.
• W2790906215 cites W2138982605 @default.
• W2790906215 cites W2141023931 @default.
• W2790906215 cites W2145878813 @default.
• W2790906215 cites W2148626940 @default.
• W2790906215 cites W2159675189 @default.
• W2790906215 cites W2164997406 @default.
• W2790906215 cites W2171252650 @default.
• W2790906215 cites W2193208524 @default.
• W2790906215 cites W2265808002 @default.
• W2790906215 cites W2274268205 @default.
• W2790906215 cites W2398309765 @default.
• W2790906215 cites W2516453631 @default.
• W2790906215 cites W2560098429 @default.
• W2790906215 cites W2607378080 @default.
• W2790906215 doi "https://doi.org/10.1111/apha.13055" @default.
• W2790906215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29436118" @default.
• W2790906215 hasPublicationYear "2018" @default.
• W2790906215 type Work @default.
• W2790906215 sameAs 2790906215 @default.
• W2790906215 citedByCount "17" @default.
• W2790906215 countsByYear W27909062152018 @default.
• W2790906215 countsByYear W27909062152019 @default.
• W2790906215 countsByYear W27909062152020 @default.
• W2790906215 countsByYear W27909062152021 @default.
• W2790906215 countsByYear W27909062152022 @default.
• W2790906215 crossrefType "journal-article" @default.
• W2790906215 hasAuthorship W2790906215A5003085792 @default.
• W2790906215 hasAuthorship W2790906215A5012272007 @default.
• W2790906215 hasAuthorship W2790906215A5019251501 @default.
• W2790906215 hasAuthorship W2790906215A5037172649 @default.
• W2790906215 hasAuthorship W2790906215A5039629749 @default.
• W2790906215 hasAuthorship W2790906215A5063531555 @default.
• W2790906215 hasAuthorship W2790906215A5089336085 @default.
• W2790906215 hasAuthorship W2790906215A5091620323 @default.
• W2790906215 hasConcept C126322002 @default.
• W2790906215 hasConcept C134018914 @default.
• W2790906215 hasConcept C182996813 @default.
• W2790906215 hasConcept C184235292 @default.
• W2790906215 hasConcept C185592680 @default.
• W2790906215 hasConcept C195794163 @default.
• W2790906215 hasConcept C2780309369 @default.
• W2790906215 hasConcept C519063684 @default.
• W2790906215 hasConcept C55493867 @default.
• W2790906215 hasConcept C71924100 @default.
• W2790906215 hasConcept C86803240 @default.
• W2790906215 hasConcept C97029542 @default.
• W2790906215 hasConceptScore W2790906215C126322002 @default.
• W2790906215 hasConceptScore W2790906215C134018914 @default.
• W2790906215 hasConceptScore W2790906215C182996813 @default.
• W2790906215 hasConceptScore W2790906215C184235292 @default.
• W2790906215 hasConceptScore W2790906215C185592680 @default.
• W2790906215 hasConceptScore W2790906215C195794163 @default.
• W2790906215 hasConceptScore W2790906215C2780309369 @default.
• W2790906215 hasConceptScore W2790906215C519063684 @default.
• W2790906215 hasConceptScore W2790906215C55493867 @default.
• W2790906215 hasConceptScore W2790906215C71924100 @default.
• W2790906215 hasConceptScore W2790906215C86803240 @default.

• next