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- W2790914475 abstract "Purpose Type 1 diabetes mellitus (DM) is associated with autoimmune diseases such as thyroiditis. Therefore, we aimed to investigate the prevalence of autoimmune thyroiditis in patients with type 1 DM. Methods A total of 102 patients who were diagnosed and followed up (mean age, 8.1±4.0 years) in Ajou University Hospital were enrolled in this study. All the patients were evaluated for beta cell autoimmunity, including insulin autoantibody, glutamic acid decarboxylase antibodies (GADA), and islet cell antibody. Moreover, autoantibodies to thyroid peroxidase and thyroglobulin were assessed at initial diagnosis and annually thereafter. Results The mean patient age (49 men and 53 women) was 19.2±4.8 years. The prevalence of at least one thyroid antibody was 30.4%. Patients with thyroid antiÂbodies had a significantly higher frequency of GADA at the time of the diagnosis. Autoimmune thyroiditis was more prevalent in the older age group. GADA was a significant risk factor for development of thyroid autoantibodies after diagnosis of type 1 DM (odds ratio, 4.45; 95% confidence interval, 1.399â14.153). Conclusions In patients with type 1 DM, the prevalence of autoimmune thyroiditis was higher than in the general population. Moreover, GADA positivity at diagnosis was associated with thyroid autoimmunity. Keywords: Autoimmune thyroiditis, Type 1 diabetes, Thyroid autoantibody" @default.
- W2790914475 created "2018-03-29" @default.
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- W2790914475 date "2018-03-31" @default.
- W2790914475 modified "2023-10-03" @default.
- W2790914475 title "Prevalence of autoimmune thyroiditis in patients with type 1 diabetes: a long-term follow-up study" @default.
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- W2790914475 doi "https://doi.org/10.6065/apem.2018.23.1.33" @default.
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