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- W2790923733 abstract "Rhabdomyolysis (RM) may cause kidney damage and results primarily in acute kidney injury (AKI). Complement is implicated in the pathogenesis of renal diseases and ischemia-reperfusion injury (IRI), but the role of complement, especially its activation pathway(s) and its effect in RM-induced AKI, is not clear. This study established a rat model of AKI induced by RM via intramuscular treatment with glycerol. Cobra venom factor (CVF) was administered via tail vein injection to deplete complement 12 h prior to intramuscular injection of glycerol. We found that the complement components, including complement 3 (C3), C1q, MBL-A, factor B(fB), C5a, C5b-9, and CD59, were significantly increased in rat kidneys after intramuscular glycerol administration. However, the levels of serum BUN and Cr, renal tubular injury scores, and the number of TUNEL-positive cells decreased significantly in the CVF+AKI group. These results suggest that complement plays an important role in RM-induced AKI and that complement depletion may improve renal function and decrease renal tissue damage by reducing the inflammatory response and apoptosis." @default.
- W2790923733 created "2018-03-29" @default.
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- W2790923733 date "2018-02-21" @default.
- W2790923733 modified "2023-10-02" @default.
- W2790923733 title "The role of complement activation in rhabdomyolysis-induced acute kidney injury" @default.
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- W2790923733 doi "https://doi.org/10.1371/journal.pone.0192361" @default.
- W2790923733 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5821337" @default.
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