Matches in SemOpenAlex for { <https://semopenalex.org/work/W2790932010> ?p ?o ?g. }
- W2790932010 endingPage "1699" @default.
- W2790932010 startingPage "1689" @default.
- W2790932010 abstract "Mesoporous silica nanoparticles (MSNs) are drug delivery agents that are able to incorporate drugs within their pores. Furthermore, MSNs can be functionalized by attachment of bioactive ligands on their surface to enhance their activity, and nanoparticles modified with glycosaminoglycan (GAG) mimetics inhibit the entry of herpes simplex virus (HSV) into cells. In this study, structure–activity relationships of GAGs attached to MSNs were investigated in relation to HSV-1 and HSV-2, and acyclovir was loaded into the pores of MSNs. The sulfonate group was demonstrated to be essential for antiviral activity, which was enhanced by incorporating a benzene group within the ligand. Loading acyclovir into GAG mimetic-functionalized MSNs reduced the viral infection, resulting in nanoparticles that simultaneously target two distinct viral pathways, namely, inhibition of viral entry and inhibition of DNA replication." @default.
- W2790932010 created "2018-03-29" @default.
- W2790932010 creator A5033373831 @default.
- W2790932010 creator A5033571466 @default.
- W2790932010 creator A5065560675 @default.
- W2790932010 creator A5077051940 @default.
- W2790932010 creator A5080291911 @default.
- W2790932010 date "2018-02-09" @default.
- W2790932010 modified "2023-10-14" @default.
- W2790932010 title "Structure–Activity Relationships of GAG Mimetic-Functionalized Mesoporous Silica Nanoparticles and Evaluation of Acyclovir-Loaded Antiviral Nanoparticles with Dual Mechanisms of Action" @default.
- W2790932010 cites W1535005981 @default.
- W2790932010 cites W1968534837 @default.
- W2790932010 cites W1970917819 @default.
- W2790932010 cites W2001371234 @default.
- W2790932010 cites W2002119161 @default.
- W2790932010 cites W2006821928 @default.
- W2790932010 cites W2011269335 @default.
- W2790932010 cites W2017746519 @default.
- W2790932010 cites W2020756150 @default.
- W2790932010 cites W2021238010 @default.
- W2790932010 cites W2030787500 @default.
- W2790932010 cites W2033077126 @default.
- W2790932010 cites W2043048846 @default.
- W2790932010 cites W2045559197 @default.
- W2790932010 cites W2046558997 @default.
- W2790932010 cites W2048056641 @default.
- W2790932010 cites W2049694755 @default.
- W2790932010 cites W2050801792 @default.
- W2790932010 cites W2054970259 @default.
- W2790932010 cites W2067007405 @default.
- W2790932010 cites W2074361358 @default.
- W2790932010 cites W2074513026 @default.
- W2790932010 cites W2075176956 @default.
- W2790932010 cites W2076977663 @default.
- W2790932010 cites W2085807488 @default.
- W2790932010 cites W2095830444 @default.
- W2790932010 cites W2100837670 @default.
- W2790932010 cites W2109074171 @default.
- W2790932010 cites W2112272805 @default.
- W2790932010 cites W2130994318 @default.
- W2790932010 cites W2139210856 @default.
- W2790932010 cites W2152170709 @default.
- W2790932010 cites W2156244991 @default.
- W2790932010 cites W2156805103 @default.
- W2790932010 cites W2163012117 @default.
- W2790932010 cites W2164060969 @default.
- W2790932010 cites W2169923259 @default.
- W2790932010 cites W2318236826 @default.
- W2790932010 cites W2321443019 @default.
- W2790932010 cites W2514493233 @default.
- W2790932010 cites W614253685 @default.
- W2790932010 doi "https://doi.org/10.1021/acsomega.7b01662" @default.
- W2790932010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6045419" @default.
- W2790932010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30023813" @default.
- W2790932010 hasPublicationYear "2018" @default.
- W2790932010 type Work @default.
- W2790932010 sameAs 2790932010 @default.
- W2790932010 citedByCount "15" @default.
- W2790932010 countsByYear W27909320102019 @default.
- W2790932010 countsByYear W27909320102020 @default.
- W2790932010 countsByYear W27909320102021 @default.
- W2790932010 countsByYear W27909320102022 @default.
- W2790932010 crossrefType "journal-article" @default.
- W2790932010 hasAuthorship W2790932010A5033373831 @default.
- W2790932010 hasAuthorship W2790932010A5033571466 @default.
- W2790932010 hasAuthorship W2790932010A5065560675 @default.
- W2790932010 hasAuthorship W2790932010A5077051940 @default.
- W2790932010 hasAuthorship W2790932010A5080291911 @default.
- W2790932010 hasBestOaLocation W27909320101 @default.
- W2790932010 hasConcept C115537861 @default.
- W2790932010 hasConcept C116569031 @default.
- W2790932010 hasConcept C12554922 @default.
- W2790932010 hasConcept C147789679 @default.
- W2790932010 hasConcept C153074725 @default.
- W2790932010 hasConcept C155672457 @default.
- W2790932010 hasConcept C159047783 @default.
- W2790932010 hasConcept C161790260 @default.
- W2790932010 hasConcept C170493617 @default.
- W2790932010 hasConcept C171250308 @default.
- W2790932010 hasConcept C178790620 @default.
- W2790932010 hasConcept C185592680 @default.
- W2790932010 hasConcept C192562407 @default.
- W2790932010 hasConcept C21951064 @default.
- W2790932010 hasConcept C2522874641 @default.
- W2790932010 hasConcept C2777496208 @default.
- W2790932010 hasConcept C2779820397 @default.
- W2790932010 hasConcept C2781196997 @default.
- W2790932010 hasConcept C55493867 @default.
- W2790932010 hasConcept C82776694 @default.
- W2790932010 hasConcept C86803240 @default.
- W2790932010 hasConceptScore W2790932010C115537861 @default.
- W2790932010 hasConceptScore W2790932010C116569031 @default.
- W2790932010 hasConceptScore W2790932010C12554922 @default.
- W2790932010 hasConceptScore W2790932010C147789679 @default.
- W2790932010 hasConceptScore W2790932010C153074725 @default.
- W2790932010 hasConceptScore W2790932010C155672457 @default.
- W2790932010 hasConceptScore W2790932010C159047783 @default.
- W2790932010 hasConceptScore W2790932010C161790260 @default.