FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2790958903> ?p ?o ?g. }

• W2790958903 endingPage "304" @default.
• W2790958903 startingPage "298" @default.
• W2790958903 abstract "Rac1 is a member of the Rho family of small GTPases that regulates cytoskeletal reorganization, membrane polarization, cell migration and proliferation. Recently, a self-activating mutation of Rac1, Rac1P29S, has been identified as a recurrent somatic mutation frequently found in sun-exposed melanomas, which possesses increased inherent GDP/GTP exchange activity and cell transforming ability. However, the role of cellular Rac1-interacting proteins in the transforming potential of Rac1P29S remains unclear. We found that the catalytic domain of DOCK1, a Rac-specific guanine nucleotide exchange factor (GEF) implicated in malignancy of a variety of cancers, can greatly accelerate the GDP/GTP exchange of Rac1P29S. Enforced expression of Rac1P29S induced matrix invasion and macropinocytosis in wild-type (WT) mouse embryonic fibroblasts (MEFs), but not in DOCK1-deficient MEFs. Consistently, a selective inhibitor of DOCK1 that blocks its GEF function suppressed the invasion and macropinocytosis in WT MEFs expressing Rac1P29S. Human melanoma IGR-1 and breast cancer MDA-MB-157 cells harbor Rac1P29S mutation and express DOCK1 endogenously. Genetic inactivation and pharmacological inhibition of DOCK1 suppressed their invasion and macropinocytosis. Taken together, these results indicate that DOCK1 is a critical regulator of the malignant phenotypes induced by Rac1P29S, and suggest that targeting DOCK1 might be an effective approach to treat cancers associated with Rac1P29S mutation." @default.
• W2790958903 created "2018-03-29" @default.
• W2790958903 creator A5004420462 @default.
• W2790958903 creator A5013407336 @default.
• W2790958903 creator A5030952055 @default.
• W2790958903 creator A5037162068 @default.
• W2790958903 creator A5037327133 @default.
• W2790958903 creator A5038100809 @default.
• W2790958903 creator A5039224020 @default.
• W2790958903 creator A5045742205 @default.
• W2790958903 creator A5050769136 @default.
• W2790958903 creator A5052040153 @default.
• W2790958903 creator A5055983625 @default.
• W2790958903 creator A5067303784 @default.
• W2790958903 creator A5074161562 @default.
• W2790958903 creator A5088288669 @default.
• W2790958903 date "2018-02-01" @default.
• W2790958903 modified "2023-10-14" @default.
• W2790958903 title "DOCK1 inhibition suppresses cancer cell invasion and macropinocytosis induced by self-activating Rac1P29S mutation" @default.
• W2790958903 cites W1568345151 @default.
• W2790958903 cites W1930083721 @default.
• W2790958903 cites W1970527559 @default.
• W2790958903 cites W1971982494 @default.
• W2790958903 cites W1982330331 @default.
• W2790958903 cites W1982486180 @default.
• W2790958903 cites W1984575247 @default.
• W2790958903 cites W1996107157 @default.
• W2790958903 cites W2011076214 @default.
• W2790958903 cites W2024222958 @default.
• W2790958903 cites W2035000040 @default.
• W2790958903 cites W2039205173 @default.
• W2790958903 cites W2042111453 @default.
• W2790958903 cites W2051208704 @default.
• W2790958903 cites W2053948677 @default.
• W2790958903 cites W2060630299 @default.
• W2790958903 cites W2081235623 @default.
• W2790958903 cites W2084566151 @default.
• W2790958903 cites W2087591542 @default.
• W2790958903 cites W2090826582 @default.
• W2790958903 cites W2102312968 @default.
• W2790958903 cites W2123778917 @default.
• W2790958903 cites W2125073987 @default.
• W2790958903 cites W2129917557 @default.
• W2790958903 cites W2134471382 @default.
• W2790958903 cites W2166273597 @default.
• W2790958903 cites W2467880345 @default.
• W2790958903 cites W2493059034 @default.
• W2790958903 cites W2611238052 @default.
• W2790958903 cites W2747641745 @default.
• W2790958903 doi "https://doi.org/10.1016/j.bbrc.2018.02.073" @default.
• W2790958903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29432733" @default.
• W2790958903 hasPublicationYear "2018" @default.
• W2790958903 type Work @default.
• W2790958903 sameAs 2790958903 @default.
• W2790958903 citedByCount "19" @default.
• W2790958903 countsByYear W27909589032018 @default.
• W2790958903 countsByYear W27909589032019 @default.
• W2790958903 countsByYear W27909589032020 @default.
• W2790958903 countsByYear W27909589032021 @default.
• W2790958903 countsByYear W27909589032022 @default.
• W2790958903 countsByYear W27909589032023 @default.
• W2790958903 crossrefType "journal-article" @default.
• W2790958903 hasAuthorship W2790958903A5004420462 @default.
• W2790958903 hasAuthorship W2790958903A5013407336 @default.
• W2790958903 hasAuthorship W2790958903A5030952055 @default.
• W2790958903 hasAuthorship W2790958903A5037162068 @default.
• W2790958903 hasAuthorship W2790958903A5037327133 @default.
• W2790958903 hasAuthorship W2790958903A5038100809 @default.
• W2790958903 hasAuthorship W2790958903A5039224020 @default.
• W2790958903 hasAuthorship W2790958903A5045742205 @default.
• W2790958903 hasAuthorship W2790958903A5050769136 @default.
• W2790958903 hasAuthorship W2790958903A5052040153 @default.
• W2790958903 hasAuthorship W2790958903A5055983625 @default.
• W2790958903 hasAuthorship W2790958903A5067303784 @default.
• W2790958903 hasAuthorship W2790958903A5074161562 @default.
• W2790958903 hasAuthorship W2790958903A5088288669 @default.
• W2790958903 hasBestOaLocation W27909589031 @default.
• W2790958903 hasConcept C104317684 @default.
• W2790958903 hasConcept C121608353 @default.
• W2790958903 hasConcept C126619667 @default.
• W2790958903 hasConcept C200786668 @default.
• W2790958903 hasConcept C207332259 @default.
• W2790958903 hasConcept C2779717556 @default.
• W2790958903 hasConcept C2909331102 @default.
• W2790958903 hasConcept C501734568 @default.
• W2790958903 hasConcept C502942594 @default.
• W2790958903 hasConcept C54355233 @default.
• W2790958903 hasConcept C62478195 @default.
• W2790958903 hasConcept C86803240 @default.
• W2790958903 hasConcept C95444343 @default.
• W2790958903 hasConcept C96232424 @default.
• W2790958903 hasConceptScore W2790958903C104317684 @default.
• W2790958903 hasConceptScore W2790958903C121608353 @default.
• W2790958903 hasConceptScore W2790958903C126619667 @default.
• W2790958903 hasConceptScore W2790958903C200786668 @default.
• W2790958903 hasConceptScore W2790958903C207332259 @default.
• W2790958903 hasConceptScore W2790958903C2779717556 @default.
• W2790958903 hasConceptScore W2790958903C2909331102 @default.

• next