FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2790962549> ?p ?o ?g. }

• W2790962549 endingPage "349" @default.
• W2790962549 startingPage "341" @default.
• W2790962549 abstract "Background: A number of phenols and parabens are added to consumer products for a variety of functions, and have been found at detectable levels in the majority of the U.S. population. Among other functions, thyroid hormones are essential in fetal neurodevelopment, and could be impacted by the endocrine disrupting effects of phenols and parabens. The present study investigated the association between ten maternal urinary phenol and paraben biomarkers (bisphenol S, triclosan, triclocarban, benzophenone-3, 2,4-dichlorophenol, 2,5-dichlorophenol, and ethyl, butyl, methyl and propyl paraben) and four plasma thyroid hormones in 439 pregnant women in a case–control sample nested within a cohort study based in Boston, MA. Methods: Urine and blood samples were collected from up to four visits during pregnancy (median weeks of gestation at each visit: Visit 1: 9.64, Visit 2: 17.9, Visit 3: 26.0, Visit 4: 35.1). Linear mixed models were constructed to take into account the repeated measures jointly, followed by multivariate linear regression models stratified by gestational age to explore potential windows of susceptibility. Results: We observed decreased total triiodothyronine (T3) in relation to an IQR increase in benzophenone-3 (percent change [%Δ] = −2.07; 95% confidence interval [CI] = −4.16, 0.01), butyl paraben (%Δ = −2.76; 95% CI = −5.25, −0.26) and triclosan (%Δ = −2.53; 95% CI = −4.75, −0.30), and triclocarban at levels above the LOD (%Δ = −5.71; 95% CI = −10.45, −0.97). A 2.41% increase in T3 was associated with an IQR increase in methyl paraben (95% CI = 0.58, 4.24). We also detected a negative association between free thyroxine (FT4) and propyl paraben (%Δ = −3.14; 95% CI = −6.12, −0.06), and a suggestive positive association between total thyroxine (T4) and methyl paraben (%Δ = 1.19; 95% CI = −0.10, 2.47). Gestational age-specific multivariate regression analyses showed that the magnitude and direction of some of the observed associations were dependent on the timing of exposure. Conclusion: Certain phenols and parabens were associated with altered thyroid hormone levels during pregnancy, and the timing of exposure influenced the association between phenol and paraben, and hormone concentrations. These changes may contribute to downstream maternal and fetal health outcomes. Additional research is required to replicate the associations, and determine the potential biological mechanisms underlying the observed associations." @default.
• W2790962549 created "2018-03-29" @default.
• W2790962549 creator A5039853092 @default.
• W2790962549 creator A5054009812 @default.
• W2790962549 creator A5065847412 @default.
• W2790962549 creator A5077009125 @default.
• W2790962549 creator A5082251592 @default.
• W2790962549 creator A5087777656 @default.
• W2790962549 date "2018-04-01" @default.
• W2790962549 modified "2023-10-13" @default.
• W2790962549 title "Associations between maternal phenol and paraben urinary biomarkers and maternal hormones during pregnancy: A repeated measures study" @default.
• W2790962549 cites W1138644445 @default.
• W2790962549 cites W1972075558 @default.
• W2790962549 cites W1972564391 @default.
• W2790962549 cites W1981348969 @default.
• W2790962549 cites W1986053132 @default.
• W2790962549 cites W1987184305 @default.
• W2790962549 cites W1989123468 @default.
• W2790962549 cites W1989429411 @default.
• W2790962549 cites W1992470121 @default.
• W2790962549 cites W1993466017 @default.
• W2790962549 cites W2002197081 @default.
• W2790962549 cites W2006104250 @default.
• W2790962549 cites W2014648910 @default.
• W2790962549 cites W2016709601 @default.
• W2790962549 cites W2020635117 @default.
• W2790962549 cites W2022236747 @default.
• W2790962549 cites W2024598483 @default.
• W2790962549 cites W2028693142 @default.
• W2790962549 cites W2033113928 @default.
• W2790962549 cites W2034039928 @default.
• W2790962549 cites W2034764968 @default.
• W2790962549 cites W2039786614 @default.
• W2790962549 cites W2043207983 @default.
• W2790962549 cites W2048681453 @default.
• W2790962549 cites W2049402124 @default.
• W2790962549 cites W2051502375 @default.
• W2790962549 cites W2056612024 @default.
• W2790962549 cites W2058680395 @default.
• W2790962549 cites W2061463820 @default.
• W2790962549 cites W2074735643 @default.
• W2790962549 cites W2076120829 @default.
• W2790962549 cites W2076754759 @default.
• W2790962549 cites W2077024018 @default.
• W2790962549 cites W2079648635 @default.
• W2790962549 cites W2083824000 @default.
• W2790962549 cites W2086369111 @default.
• W2790962549 cites W2087175878 @default.
• W2790962549 cites W2088501367 @default.
• W2790962549 cites W2089311997 @default.
• W2790962549 cites W2091444084 @default.
• W2790962549 cites W2115839831 @default.
• W2790962549 cites W2119956943 @default.
• W2790962549 cites W2124138172 @default.
• W2790962549 cites W2146031543 @default.
• W2790962549 cites W2156485374 @default.
• W2790962549 cites W2160705379 @default.
• W2790962549 cites W2190061871 @default.
• W2790962549 cites W2194427753 @default.
• W2790962549 cites W2227225628 @default.
• W2790962549 cites W2320201861 @default.
• W2790962549 cites W2329387328 @default.
• W2790962549 cites W2344335473 @default.
• W2790962549 cites W2345538504 @default.
• W2790962549 cites W2345569386 @default.
• W2790962549 cites W2345620911 @default.
• W2790962549 cites W2403022207 @default.
• W2790962549 cites W2414331121 @default.
• W2790962549 cites W2477887382 @default.
• W2790962549 cites W2500290585 @default.
• W2790962549 cites W2509941917 @default.
• W2790962549 cites W2540670544 @default.
• W2790962549 cites W2553727184 @default.
• W2790962549 cites W2556640010 @default.
• W2790962549 cites W2556913407 @default.
• W2790962549 cites W2568063541 @default.
• W2790962549 cites W2584183869 @default.
• W2790962549 cites W2590775672 @default.
• W2790962549 cites W2599402689 @default.
• W2790962549 cites W2599553288 @default.
• W2790962549 cites W2606814450 @default.
• W2790962549 cites W2610594105 @default.
• W2790962549 cites W2611655594 @default.
• W2790962549 cites W2639334242 @default.
• W2790962549 cites W2653132777 @default.
• W2790962549 cites W2730372385 @default.
• W2790962549 doi "https://doi.org/10.1016/j.envint.2018.01.006" @default.
• W2790962549 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5866216" @default.
• W2790962549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29366524" @default.
• W2790962549 hasPublicationYear "2018" @default.
• W2790962549 type Work @default.
• W2790962549 sameAs 2790962549 @default.
• W2790962549 citedByCount "85" @default.
• W2790962549 countsByYear W27909625492018 @default.
• W2790962549 countsByYear W27909625492019 @default.
• W2790962549 countsByYear W27909625492020 @default.
• W2790962549 countsByYear W27909625492021 @default.
• W2790962549 countsByYear W27909625492022 @default.

• next