FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2790986393> ?p ?o ?g. }

• W2790986393 endingPage "162" @default.
• W2790986393 startingPage "156" @default.
• W2790986393 abstract "Objectives. With a steadily growing number of patients with non-valvular atrial fibrillation, anticoagulation use increases. Anticoagulation therapy is associated with increased risk of serious bleeding and an increased complexity in management of patients in need for urgent surgery. We wanted to assess the magnitude of this challenge as well as review current and potential future clinical management strategies. Design. A review of the literature on the magnitude of patients using antigoaculants in potential need for acute restoration of hemostasis was conducted, as well as current status of reversal agents for non-vitamin K antagonist oral anticoagulants (NOACs). Additionally, a case illustration of its use is presented. Results. Two main groups of patients may need acute restoration of hemostasis, those in need of acute surgery or acute invasive procedures, ∼ 2% of patients annually, and those with serious and critical hemorrhage, ∼1.5% annually. One specific reversal agent is available on the market (idarucizumab) and two (andexanet alfa, ciraparantag) are in clinical development. Idarucizumab is a specific antidote for the thrombin inhibitor dabigatran while andexanet alfa is factor Xa inhibitor class-specific currently in late-stage development. Ciraparantag is a universal reversal agent in early-phase development. These agents can facilitate effective management of bleeding or bleeding risk, as illustrated in a patient on dabigatran in urgent need for a pacemaker. Conclusions. Amongst patients using anticoagulants, around 3.5%, could be in need of immediate restoration of hemostasis annually. The availability and use of specific reversal agents for NOACs could be crucial for the clinical outcomes." @default.
• W2790986393 created "2018-03-29" @default.
• W2790986393 creator A5001562001 @default.
• W2790986393 creator A5008842761 @default.
• W2790986393 creator A5049802776 @default.
• W2790986393 creator A5074317521 @default.
• W2790986393 creator A5076961983 @default.
• W2790986393 creator A5089224223 @default.
• W2790986393 date "2018-03-23" @default.
• W2790986393 modified "2023-09-25" @default.
• W2790986393 title "Mechanisms of action and clinical use of specific reversal agents for non-vitamin K antagonist oral anticoagulants" @default.
• W2790986393 cites W1913182214 @default.
• W2790986393 cites W1924621163 @default.
• W2790986393 cites W2003264403 @default.
• W2790986393 cites W2015751459 @default.
• W2790986393 cites W2021808899 @default.
• W2790986393 cites W2038695648 @default.
• W2790986393 cites W2045273044 @default.
• W2790986393 cites W2061063479 @default.
• W2790986393 cites W2092165341 @default.
• W2790986393 cites W2096246254 @default.
• W2790986393 cites W2097854437 @default.
• W2790986393 cites W2106414997 @default.
• W2790986393 cites W2106760090 @default.
• W2790986393 cites W2109776710 @default.
• W2790986393 cites W2125214232 @default.
• W2790986393 cites W2136489990 @default.
• W2790986393 cites W2147018083 @default.
• W2790986393 cites W2152623033 @default.
• W2790986393 cites W2158143297 @default.
• W2790986393 cites W2159975225 @default.
• W2790986393 cites W2162508946 @default.
• W2790986393 cites W2180485481 @default.
• W2790986393 cites W2236351932 @default.
• W2790986393 cites W2317611630 @default.
• W2790986393 cites W2514338974 @default.
• W2790986393 cites W2598370951 @default.
• W2790986393 cites W2724431303 @default.
• W2790986393 cites W2734827407 @default.
• W2790986393 cites W2766233233 @default.
• W2790986393 cites W3004050106 @default.
• W2790986393 doi "https://doi.org/10.1080/14017431.2018.1453613" @default.
• W2790986393 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29569500" @default.
• W2790986393 hasPublicationYear "2018" @default.
• W2790986393 type Work @default.
• W2790986393 sameAs 2790986393 @default.
• W2790986393 citedByCount "6" @default.
• W2790986393 countsByYear W27909863932018 @default.
• W2790986393 countsByYear W27909863932019 @default.
• W2790986393 countsByYear W27909863932020 @default.
• W2790986393 countsByYear W27909863932023 @default.
• W2790986393 crossrefType "journal-article" @default.
• W2790986393 hasAuthorship W2790986393A5001562001 @default.
• W2790986393 hasAuthorship W2790986393A5008842761 @default.
• W2790986393 hasAuthorship W2790986393A5049802776 @default.
• W2790986393 hasAuthorship W2790986393A5074317521 @default.
• W2790986393 hasAuthorship W2790986393A5076961983 @default.
• W2790986393 hasAuthorship W2790986393A5089224223 @default.
• W2790986393 hasConcept C126322002 @default.
• W2790986393 hasConcept C141071460 @default.
• W2790986393 hasConcept C177713679 @default.
• W2790986393 hasConcept C2776301958 @default.
• W2790986393 hasConcept C2776413415 @default.
• W2790986393 hasConcept C2776704044 @default.
• W2790986393 hasConcept C2778589496 @default.
• W2790986393 hasConcept C2778810321 @default.
• W2790986393 hasConcept C2779161974 @default.
• W2790986393 hasConcept C71924100 @default.
• W2790986393 hasConceptScore W2790986393C126322002 @default.
• W2790986393 hasConceptScore W2790986393C141071460 @default.
• W2790986393 hasConceptScore W2790986393C177713679 @default.
• W2790986393 hasConceptScore W2790986393C2776301958 @default.
• W2790986393 hasConceptScore W2790986393C2776413415 @default.
• W2790986393 hasConceptScore W2790986393C2776704044 @default.
• W2790986393 hasConceptScore W2790986393C2778589496 @default.
• W2790986393 hasConceptScore W2790986393C2778810321 @default.
• W2790986393 hasConceptScore W2790986393C2779161974 @default.
• W2790986393 hasConceptScore W2790986393C71924100 @default.
• W2790986393 hasIssue "3" @default.
• W2790986393 hasLocation W27909863931 @default.
• W2790986393 hasLocation W27909863932 @default.
• W2790986393 hasOpenAccess W2790986393 @default.
• W2790986393 hasPrimaryLocation W27909863931 @default.
• W2790986393 hasRelatedWork W2515923010 @default.
• W2790986393 hasRelatedWork W2603623757 @default.
• W2790986393 hasRelatedWork W2763816051 @default.
• W2790986393 hasRelatedWork W2898731223 @default.
• W2790986393 hasRelatedWork W3005086682 @default.
• W2790986393 hasRelatedWork W3020215883 @default.
• W2790986393 hasRelatedWork W3173880122 @default.
• W2790986393 hasRelatedWork W4296619345 @default.
• W2790986393 hasRelatedWork W1513839038 @default.
• W2790986393 hasRelatedWork W168870552 @default.
• W2790986393 hasVolume "52" @default.
• W2790986393 isParatext "false" @default.
• W2790986393 isRetracted "false" @default.
• W2790986393 magId "2790986393" @default.
• W2790986393 workType "article" @default.