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• W2791004087 abstract "Mycobacterium tuberculosis is a notorious pathogen that continues to threaten human health. Rv0164, an antigen of both T‐ and B cells conserved across mycobacteria, and MSMEG _0129, its close homolog in Mycobacterium smegmatis , are predicted members of the START domain superfamily, but their molecular function is unknown. Here, gene knockout studies demonstrate MSMEG _0129 is essential for bacterial growth, suggesting Rv0164 may be a potential drug target. The MSMEG _0129 crystal structure determined at 1.95 Å reveals a fold similar to that in polyketide aromatase/cyclases ZhuI and TcmN from Streptomyces sp. Structural comparisons and docking simulations, however, infer that MSMEG _0129 and Rv0164 are unlikely to catalyze polyketide aromatization/cyclization, but probably play an irreplaceable role during mycobacterial growth, for example, in lipid transfer during cell envelope synthesis." @default.
• W2791004087 created "2018-03-29" @default.
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• W2791004087 date "2018-04-01" @default.
• W2791004087 modified "2023-10-15" @default.
• W2791004087 title "Structural and genetic analysis of<scp>START</scp>superfamily protein<scp>MSMEG</scp>_0129 from<i>Mycobacterium smegmatis</i>" @default.
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• W2791004087 doi "https://doi.org/10.1002/1873-3468.13024" @default.
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• W2791004087 hasPublicationYear "2018" @default.
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