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• W2791008574 abstract "Oxidative and electrophilic changes in cells are mainly coordinated by the KEAP1/NRF2 (Kelch-like erythroid-derived cap-n-collar homology- (ECH-) associated protein-1/nuclear factor (erythroid-derived 2)-like 2) axis. The physical interaction between these two proteins promotes the expression of several antioxidant defense genes in response to exogenous and endogenous insults. Recent studies demonstrated that KEAP1/NRF2 axis dysfunction is also strongly related to tumor progression and chemo- and radiotherapy resistance of cancer cells. In solid tumors, the KEAP1/NRF2 system is constitutively activated by the loss of KEAP1 or gain of NFE2L2 functions that leads to its nuclear accumulation and enhances the transcription of many cytoprotective genes. In addition to point mutations, epigenetic abnormalities, as aberrant promoter methylation, and microRNA (miRNA) and long noncoding RNA (lncRNA) deregulation were reported as emerging mechanisms of KEAP1/NRF2 axis modulation. This review will summarize the current knowledge about the epigenetic mechanisms that deregulate the KEAP1/NRF2 cascade in solid tumors and their potential usefulness as prognostic and predictive molecular markers." @default.
• W2791008574 created "2018-03-29" @default.
• W2791008574 creator A5010948827 @default.
• W2791008574 creator A5036881691 @default.
• W2791008574 creator A5043200158 @default.
• W2791008574 creator A5067117962 @default.
• W2791008574 date "2018-01-01" @default.
• W2791008574 modified "2023-10-16" @default.
• W2791008574 title "Epigenetic versus Genetic Deregulation of the KEAP1/NRF2 Axis in Solid Tumors: Focus on Methylation and Noncoding RNAs" @default.
• W2791008574 cites W1231316025 @default.
• W2791008574 cites W1498098115 @default.
• W2791008574 cites W1544328481 @default.
• W2791008574 cites W1638800501 @default.
• W2791008574 cites W1785455093 @default.
• W2791008574 cites W1785580848 @default.
• W2791008574 cites W1789875395 @default.
• W2791008574 cites W1903523058 @default.
• W2791008574 cites W1906881916 @default.
• W2791008574 cites W1912692550 @default.
• W2791008574 cites W1927599683 @default.
• W2791008574 cites W1957136694 @default.
• W2791008574 cites W1962460712 @default.
• W2791008574 cites W1967108243 @default.
• W2791008574 cites W1972793256 @default.
• W2791008574 cites W197322975 @default.
• W2791008574 cites W1974546855 @default.
• W2791008574 cites W1976150924 @default.
• W2791008574 cites W1976441209 @default.
• W2791008574 cites W1976949137 @default.
• W2791008574 cites W1979021654 @default.
• W2791008574 cites W1980686102 @default.
• W2791008574 cites W1980739328 @default.
• W2791008574 cites W1983565617 @default.
• W2791008574 cites W1987855842 @default.
• W2791008574 cites W1989626257 @default.
• W2791008574 cites W1992724001 @default.
• W2791008574 cites W1994604625 @default.
• W2791008574 cites W1999736822 @default.
• W2791008574 cites W2001568293 @default.
• W2791008574 cites W2003624918 @default.
• W2791008574 cites W2004840945 @default.
• W2791008574 cites W2007696041 @default.
• W2791008574 cites W2009902735 @default.
• W2791008574 cites W2010664998 @default.
• W2791008574 cites W2017657232 @default.
• W2791008574 cites W2018851752 @default.
• W2791008574 cites W2027287873 @default.
• W2791008574 cites W2028673321 @default.
• W2791008574 cites W2030181022 @default.
• W2791008574 cites W2030252491 @default.
• W2791008574 cites W2033633352 @default.
• W2791008574 cites W2037048830 @default.
• W2791008574 cites W2040114786 @default.
• W2791008574 cites W2043281296 @default.
• W2791008574 cites W2052041317 @default.
• W2791008574 cites W2055573907 @default.
• W2791008574 cites W2058493148 @default.
• W2791008574 cites W2059129804 @default.
• W2791008574 cites W2067611825 @default.
• W2791008574 cites W2068232187 @default.
• W2791008574 cites W2082789532 @default.
• W2791008574 cites W2088911685 @default.
• W2791008574 cites W2088953003 @default.
• W2791008574 cites W2090403154 @default.
• W2791008574 cites W2096172976 @default.
• W2791008574 cites W2096791553 @default.
• W2791008574 cites W2100338157 @default.
• W2791008574 cites W2100441605 @default.
• W2791008574 cites W2103407095 @default.
• W2791008574 cites W2106674569 @default.
• W2791008574 cites W2113209201 @default.
• W2791008574 cites W2116142441 @default.
• W2791008574 cites W2116439283 @default.
• W2791008574 cites W2118793608 @default.
• W2791008574 cites W2124112939 @default.
• W2791008574 cites W2126248794 @default.
• W2791008574 cites W2132194692 @default.
• W2791008574 cites W2135514225 @default.
• W2791008574 cites W2137131553 @default.
• W2791008574 cites W2137862511 @default.
• W2791008574 cites W2142449962 @default.
• W2791008574 cites W2144038313 @default.
• W2791008574 cites W2146648170 @default.
• W2791008574 cites W2147335382 @default.
• W2791008574 cites W2152937132 @default.
• W2791008574 cites W2153772231 @default.
• W2791008574 cites W2154026937 @default.
• W2791008574 cites W2154330794 @default.
• W2791008574 cites W2158378236 @default.
• W2791008574 cites W2160921325 @default.
• W2791008574 cites W2161446823 @default.
• W2791008574 cites W2167803469 @default.
• W2791008574 cites W2168713325 @default.
• W2791008574 cites W2170889480 @default.
• W2791008574 cites W2275877493 @default.
• W2791008574 cites W2276858159 @default.
• W2791008574 cites W2324495655 @default.
• W2791008574 cites W2403931162 @default.

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