Matches in SemOpenAlex for { <https://semopenalex.org/work/W2791036758> ?p ?o ?g. }
- W2791036758 endingPage "476" @default.
- W2791036758 startingPage "467" @default.
- W2791036758 abstract "In a previous study on discovering new antimicrobial agents from microbial sources, nine bafilomycins were isolated from the fermentation broth of Streptomyces albolongus. Among them, bafilomycin C1 (Baf C1) showed strong antifungal activity against Candida albicans, with MIC value of 1.56 μg/mL. The aim of this study was to evaluate the action mechanism of Baf C1 against C. albicans. Quantitative PCR analysis revealed that ergosterol biosynthesis-related genes of C. albicans ACS1, HMG1, IDI1, ERG1, ERG2, ERG6, ERG7, ERG8, ERG9, ERG12, ERG13, ERG20, ERG24, ERG251, ERG252, ERG26, ERG27, and ERG28 were all down-regulated (Log2fold change < −1) after Baf C1(4 μg/mL) exposure. Moreover, the expression of MET6 gene, encoded methionine synthase, was also down-regulated (2.7-fold). It is corresponding with the quantitative PCR result, the content of ergosterol has dropped about 41% compared with the control. Transmission electron microscope examination also revealed that the Baf C1 strongly destroyed the cell membrane of C. albicans. In addition, the content of farnesol was significantly increased, about 2.1-fold compared with the control. The results indicated Baf C1 caused aberrations in sterol biosynthesis, leaded to the lack of ergosterol of the fungal membrane." @default.
- W2791036758 created "2018-03-29" @default.
- W2791036758 creator A5008919007 @default.
- W2791036758 creator A5015404110 @default.
- W2791036758 creator A5023258470 @default.
- W2791036758 creator A5063192101 @default.
- W2791036758 creator A5086925010 @default.
- W2791036758 creator A5089488563 @default.
- W2791036758 date "2018-02-01" @default.
- W2791036758 modified "2023-10-14" @default.
- W2791036758 title "Bafilomycin C1 exert antifungal effect through disturbing sterol biosynthesis in Candida albicans" @default.
- W2791036758 cites W1514738334 @default.
- W2791036758 cites W1776905503 @default.
- W2791036758 cites W1927812867 @default.
- W2791036758 cites W1986858209 @default.
- W2791036758 cites W2007980078 @default.
- W2791036758 cites W2020138750 @default.
- W2791036758 cites W2033844645 @default.
- W2791036758 cites W2037748598 @default.
- W2791036758 cites W2049505636 @default.
- W2791036758 cites W2050335832 @default.
- W2791036758 cites W2055613311 @default.
- W2791036758 cites W2061514093 @default.
- W2791036758 cites W2072901726 @default.
- W2791036758 cites W2095926990 @default.
- W2791036758 cites W2097771377 @default.
- W2791036758 cites W2102112528 @default.
- W2791036758 cites W2131386377 @default.
- W2791036758 cites W2136744511 @default.
- W2791036758 cites W2136753636 @default.
- W2791036758 cites W2144677145 @default.
- W2791036758 cites W2149504447 @default.
- W2791036758 cites W2149698468 @default.
- W2791036758 cites W2151208600 @default.
- W2791036758 cites W2154640684 @default.
- W2791036758 cites W2156682134 @default.
- W2791036758 cites W2157705024 @default.
- W2791036758 cites W2158241162 @default.
- W2791036758 cites W2161253853 @default.
- W2791036758 cites W2165174560 @default.
- W2791036758 cites W2165461758 @default.
- W2791036758 cites W2166075607 @default.
- W2791036758 cites W2168781246 @default.
- W2791036758 cites W2170040727 @default.
- W2791036758 cites W2196186584 @default.
- W2791036758 cites W2274626913 @default.
- W2791036758 cites W2336414827 @default.
- W2791036758 cites W2406750391 @default.
- W2791036758 cites W84273483 @default.
- W2791036758 doi "https://doi.org/10.1038/s41429-017-0009-8" @default.
- W2791036758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29391532" @default.
- W2791036758 hasPublicationYear "2018" @default.
- W2791036758 type Work @default.
- W2791036758 sameAs 2791036758 @default.
- W2791036758 citedByCount "8" @default.
- W2791036758 countsByYear W27910367582018 @default.
- W2791036758 countsByYear W27910367582019 @default.
- W2791036758 countsByYear W27910367582020 @default.
- W2791036758 countsByYear W27910367582021 @default.
- W2791036758 countsByYear W27910367582023 @default.
- W2791036758 crossrefType "journal-article" @default.
- W2791036758 hasAuthorship W2791036758A5008919007 @default.
- W2791036758 hasAuthorship W2791036758A5015404110 @default.
- W2791036758 hasAuthorship W2791036758A5023258470 @default.
- W2791036758 hasAuthorship W2791036758A5063192101 @default.
- W2791036758 hasAuthorship W2791036758A5086925010 @default.
- W2791036758 hasAuthorship W2791036758A5089488563 @default.
- W2791036758 hasBestOaLocation W27910367581 @default.
- W2791036758 hasConcept C104317684 @default.
- W2791036758 hasConcept C145081991 @default.
- W2791036758 hasConcept C2777910421 @default.
- W2791036758 hasConcept C2778163477 @default.
- W2791036758 hasConcept C2778718757 @default.
- W2791036758 hasConcept C2779548794 @default.
- W2791036758 hasConcept C2779732960 @default.
- W2791036758 hasConcept C2780628323 @default.
- W2791036758 hasConcept C2780917455 @default.
- W2791036758 hasConcept C2780992308 @default.
- W2791036758 hasConcept C2781088250 @default.
- W2791036758 hasConcept C553450214 @default.
- W2791036758 hasConcept C55493867 @default.
- W2791036758 hasConcept C86803240 @default.
- W2791036758 hasConcept C89423630 @default.
- W2791036758 hasConceptScore W2791036758C104317684 @default.
- W2791036758 hasConceptScore W2791036758C145081991 @default.
- W2791036758 hasConceptScore W2791036758C2777910421 @default.
- W2791036758 hasConceptScore W2791036758C2778163477 @default.
- W2791036758 hasConceptScore W2791036758C2778718757 @default.
- W2791036758 hasConceptScore W2791036758C2779548794 @default.
- W2791036758 hasConceptScore W2791036758C2779732960 @default.
- W2791036758 hasConceptScore W2791036758C2780628323 @default.
- W2791036758 hasConceptScore W2791036758C2780917455 @default.
- W2791036758 hasConceptScore W2791036758C2780992308 @default.
- W2791036758 hasConceptScore W2791036758C2781088250 @default.
- W2791036758 hasConceptScore W2791036758C553450214 @default.
- W2791036758 hasConceptScore W2791036758C55493867 @default.
- W2791036758 hasConceptScore W2791036758C86803240 @default.
- W2791036758 hasConceptScore W2791036758C89423630 @default.