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- W2791064642 abstract "Clofarabine and cytarabine (Clo + Ara-C) combinations have efficacy in treatment of acute myeloid leukemia (AML). We retrospectively analyzed clinical outcomes of 71 AML patients receiving Clo + Ara-C regimens at the University of Minnesota from 2011 to 2016: 44 patients (62%) had newly diagnosed AML and 27 patients (38%) had relapsed/refractory AML. The median age of patients was 69 years (interquartile range [IQR], 63-75 years). Nearly 60% of the patients had secondary AML, and about half of patients had adverse risk cytogenetics. Objective response rate (ORR) was 42% in all patients with complete remission (CR) rate of 20%. Progression-free survival (PFS) at 2 years was 16% (95% CI 8-27%) and overall survival (OS) at 2 years was 21% (95% CI 11-33%) for all patients. The 30-day mortality rate was 18%. Clo + Ara-C- containing regimens are an acceptable upfront therapy option for patients who are not candidates for 7 + 3 induction, but do not induce durable remissions." @default.
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- W2791064642 date "2018-02-07" @default.
- W2791064642 modified "2023-09-25" @default.
- W2791064642 title "A real-world study of clofarabine and cytarabine combination therapy for patients with acute myeloid leukemia" @default.
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- W2791064642 doi "https://doi.org/10.1080/10428194.2018.1433297" @default.
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