Matches in SemOpenAlex for { <https://semopenalex.org/work/W2791069126> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2791069126 endingPage "517" @default.
- W2791069126 startingPage "511" @default.
- W2791069126 abstract "Abstract Hepatitis B virus (HBV) targets the liver and is a major driver for liver cancer. Clinical data suggest that HBV infection is associated with reduced response to treatment with the multi-kinase inhibitor sorafenib, the first available molecularly targeted anti-hepatocellular carcinoma (HCC) drug. Given that Raf is one of the major targets of sorafenib, we investigated the activation state of the Raf-Mek-Erk pathway in the presence of HBV and in response to sorafenib. Here we show that hepatoma cells with replicating HBV are less susceptible to sorafenib inhibitory effect as compared to cells in which HBV expression is suppressed. However, although HBV replication is associated with increased level of pErk, its blockade only modestly augments sorafenib effect. In contrast, the phosphorylated form of the pro-oncogenic Mitogen-Activated Protein Kinase 14 (pMAPK14), a protein kinase that was recently linked to sorafenib resistance, is induced in sorafenib-treated hepatoma cells in association with HBV X protein expression. Knocking down pMAPK14 results in augmentation of the therapeutic efficacy of sorafenib and largely alleviates resistance to sorafenib in the presence of HBV. Thus, this study suggests that HBV promotes HCC resistance to sorafenib. Combining pMAPK14 inhibitors with sorafenib may be beneficial in patients with HBV-associated HCC." @default.
- W2791069126 created "2018-03-29" @default.
- W2791069126 creator A5033915405 @default.
- W2791069126 creator A5043650841 @default.
- W2791069126 creator A5062212324 @default.
- W2791069126 creator A5074737362 @default.
- W2791069126 creator A5082485854 @default.
- W2791069126 date "2018-04-01" @default.
- W2791069126 modified "2023-09-26" @default.
- W2791069126 title "Inhibition of pMAPK14 Overcomes Resistance to Sorafenib in Hepatoma Cells with Hepatitis B Virus" @default.
- W2791069126 cites W1542425243 @default.
- W2791069126 cites W1690185597 @default.
- W2791069126 cites W1749960448 @default.
- W2791069126 cites W1971837077 @default.
- W2791069126 cites W1989647054 @default.
- W2791069126 cites W1998697663 @default.
- W2791069126 cites W2005383067 @default.
- W2791069126 cites W2010338556 @default.
- W2791069126 cites W2019218097 @default.
- W2791069126 cites W2024450952 @default.
- W2791069126 cites W2032592312 @default.
- W2791069126 cites W2034992482 @default.
- W2791069126 cites W2044951291 @default.
- W2791069126 cites W2047743944 @default.
- W2791069126 cites W2061345986 @default.
- W2791069126 cites W2070396671 @default.
- W2791069126 cites W2088629624 @default.
- W2791069126 cites W2092888413 @default.
- W2791069126 cites W2112135110 @default.
- W2791069126 cites W2128227067 @default.
- W2791069126 cites W2128871289 @default.
- W2791069126 cites W2129866880 @default.
- W2791069126 cites W2149848093 @default.
- W2791069126 cites W2163403599 @default.
- W2791069126 cites W2286872394 @default.
- W2791069126 cites W4245403358 @default.
- W2791069126 doi "https://doi.org/10.1016/j.tranon.2018.02.015" @default.
- W2791069126 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5884218" @default.
- W2791069126 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29524828" @default.
- W2791069126 hasPublicationYear "2018" @default.
- W2791069126 type Work @default.
- W2791069126 sameAs 2791069126 @default.
- W2791069126 citedByCount "14" @default.
- W2791069126 countsByYear W27910691262019 @default.
- W2791069126 countsByYear W27910691262020 @default.
- W2791069126 countsByYear W27910691262021 @default.
- W2791069126 countsByYear W27910691262022 @default.
- W2791069126 crossrefType "journal-article" @default.
- W2791069126 hasAuthorship W2791069126A5033915405 @default.
- W2791069126 hasAuthorship W2791069126A5043650841 @default.
- W2791069126 hasAuthorship W2791069126A5062212324 @default.
- W2791069126 hasAuthorship W2791069126A5074737362 @default.
- W2791069126 hasAuthorship W2791069126A5082485854 @default.
- W2791069126 hasBestOaLocation W27910691261 @default.
- W2791069126 hasConcept C159047783 @default.
- W2791069126 hasConcept C2522874641 @default.
- W2791069126 hasConcept C2777382497 @default.
- W2791069126 hasConcept C2778019345 @default.
- W2791069126 hasConcept C2778695046 @default.
- W2791069126 hasConcept C2780593183 @default.
- W2791069126 hasConcept C2983655198 @default.
- W2791069126 hasConcept C3019983190 @default.
- W2791069126 hasConcept C502942594 @default.
- W2791069126 hasConcept C71924100 @default.
- W2791069126 hasConceptScore W2791069126C159047783 @default.
- W2791069126 hasConceptScore W2791069126C2522874641 @default.
- W2791069126 hasConceptScore W2791069126C2777382497 @default.
- W2791069126 hasConceptScore W2791069126C2778019345 @default.
- W2791069126 hasConceptScore W2791069126C2778695046 @default.
- W2791069126 hasConceptScore W2791069126C2780593183 @default.
- W2791069126 hasConceptScore W2791069126C2983655198 @default.
- W2791069126 hasConceptScore W2791069126C3019983190 @default.
- W2791069126 hasConceptScore W2791069126C502942594 @default.
- W2791069126 hasConceptScore W2791069126C71924100 @default.
- W2791069126 hasIssue "2" @default.
- W2791069126 hasLocation W27910691261 @default.
- W2791069126 hasLocation W27910691262 @default.
- W2791069126 hasLocation W27910691263 @default.
- W2791069126 hasLocation W27910691264 @default.
- W2791069126 hasOpenAccess W2791069126 @default.
- W2791069126 hasPrimaryLocation W27910691261 @default.
- W2791069126 hasRelatedWork W1166134733 @default.
- W2791069126 hasRelatedWork W2078884611 @default.
- W2791069126 hasRelatedWork W2613819916 @default.
- W2791069126 hasRelatedWork W2791069126 @default.
- W2791069126 hasRelatedWork W2888296588 @default.
- W2791069126 hasRelatedWork W2890390561 @default.
- W2791069126 hasRelatedWork W3123342034 @default.
- W2791069126 hasRelatedWork W3170423016 @default.
- W2791069126 hasRelatedWork W3186687411 @default.
- W2791069126 hasRelatedWork W4200590228 @default.
- W2791069126 hasVolume "11" @default.
- W2791069126 isParatext "false" @default.
- W2791069126 isRetracted "false" @default.
- W2791069126 magId "2791069126" @default.
- W2791069126 workType "article" @default.