Matches in SemOpenAlex for { <https://semopenalex.org/work/W2791071159> ?p ?o ?g. }
- W2791071159 abstract "A conserved feature of the central nervous system (CNS) is the prominent expansion of anterior regions (brain) when compared to posterior (nerve cord). The cellular and regulatory processes driving anterior CNS expansion are not well understood in any bilaterian species. Here, we address this expansion in Drosophila and mouse. We find that when compared to the nerve cord the brain, in both Drosophila and mouse, displays extended progenitor proliferation, more elaborate daughter cell proliferation and more rapid cell cycle speed. These features contribute to anterior CNS expansion in both species. With respect to genetic control, enhanced brain proliferation is severely reduced by ectopic Hox gene expression, by either Hox misexpression or by loss of Polycomb Group (PcG) function. Strikingly, in PcG mutants, early CNS proliferation appears unaffected, whereas subsequently, brain proliferation is severely reduced. Hence, a conserved PcG-Hox program promotes the anterior expansion of the CNS. The profound differences in proliferation and in the underlying genetic mechanisms between brain and nerve cord lend support to the emerging concept of separate evolutionary origins of these two CNS regions." @default.
- W2791071159 created "2018-03-29" @default.
- W2791071159 creator A5025416685 @default.
- W2791071159 creator A5027762723 @default.
- W2791071159 creator A5037026280 @default.
- W2791071159 creator A5051002476 @default.
- W2791071159 creator A5054627494 @default.
- W2791071159 creator A5055124684 @default.
- W2791071159 creator A5087541434 @default.
- W2791071159 date "2018-01-01" @default.
- W2791071159 modified "2023-09-25" @default.
- W2791071159 title "Evolutionarily conserved anterior expansion of the central nervous system promoted by a common PcG-Hox program" @default.
- W2791071159 cites W1504807885 @default.
- W2791071159 cites W1524992328 @default.
- W2791071159 cites W1968002000 @default.
- W2791071159 cites W1970756199 @default.
- W2791071159 cites W1981336776 @default.
- W2791071159 cites W1981569192 @default.
- W2791071159 cites W1981933369 @default.
- W2791071159 cites W1983163936 @default.
- W2791071159 cites W1985348819 @default.
- W2791071159 cites W1988976106 @default.
- W2791071159 cites W1990935914 @default.
- W2791071159 cites W1991545433 @default.
- W2791071159 cites W2009105413 @default.
- W2791071159 cites W2010994321 @default.
- W2791071159 cites W2013223879 @default.
- W2791071159 cites W2013364492 @default.
- W2791071159 cites W2015886976 @default.
- W2791071159 cites W2024185372 @default.
- W2791071159 cites W2026998481 @default.
- W2791071159 cites W2031330263 @default.
- W2791071159 cites W2036227773 @default.
- W2791071159 cites W2040461990 @default.
- W2791071159 cites W2044627216 @default.
- W2791071159 cites W2045282282 @default.
- W2791071159 cites W2049831767 @default.
- W2791071159 cites W2052072871 @default.
- W2791071159 cites W2053564909 @default.
- W2791071159 cites W2055302801 @default.
- W2791071159 cites W2058903813 @default.
- W2791071159 cites W2060631152 @default.
- W2791071159 cites W2061428463 @default.
- W2791071159 cites W2065625201 @default.
- W2791071159 cites W2067153133 @default.
- W2791071159 cites W2070501211 @default.
- W2791071159 cites W2070603405 @default.
- W2791071159 cites W2079186910 @default.
- W2791071159 cites W2079883339 @default.
- W2791071159 cites W2082414547 @default.
- W2791071159 cites W2084652685 @default.
- W2791071159 cites W2093712120 @default.
- W2791071159 cites W2097065859 @default.
- W2791071159 cites W2107227145 @default.
- W2791071159 cites W2111047004 @default.
- W2791071159 cites W2111322331 @default.
- W2791071159 cites W2116847257 @default.
- W2791071159 cites W2120418467 @default.
- W2791071159 cites W2121558276 @default.
- W2791071159 cites W2122910069 @default.
- W2791071159 cites W2125037869 @default.
- W2791071159 cites W2127136880 @default.
- W2791071159 cites W2127393109 @default.
- W2791071159 cites W2128527975 @default.
- W2791071159 cites W2131278302 @default.
- W2791071159 cites W2139360357 @default.
- W2791071159 cites W2139814794 @default.
- W2791071159 cites W2150225740 @default.
- W2791071159 cites W2151777177 @default.
- W2791071159 cites W2153478835 @default.
- W2791071159 cites W2155585799 @default.
- W2791071159 cites W2156755609 @default.
- W2791071159 cites W2160513150 @default.
- W2791071159 cites W2162938913 @default.
- W2791071159 cites W2167279371 @default.
- W2791071159 cites W2167593243 @default.
- W2791071159 cites W2186697921 @default.
- W2791071159 cites W2219074388 @default.
- W2791071159 cites W2268332370 @default.
- W2791071159 cites W2273534907 @default.
- W2791071159 cites W2315446157 @default.
- W2791071159 cites W2335986232 @default.
- W2791071159 cites W2338141765 @default.
- W2791071159 cites W2419237034 @default.
- W2791071159 cites W2585516039 @default.
- W2791071159 cites W2604362065 @default.
- W2791071159 cites W2610342468 @default.
- W2791071159 cites W2767642029 @default.
- W2791071159 cites W2774307240 @default.
- W2791071159 cites W2950507998 @default.
- W2791071159 cites W33805216 @default.
- W2791071159 cites W4300448772 @default.
- W2791071159 cites W1965835452 @default.
- W2791071159 doi "https://doi.org/10.1242/dev.160747" @default.
- W2791071159 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29530878" @default.
- W2791071159 hasPublicationYear "2018" @default.
- W2791071159 type Work @default.
- W2791071159 sameAs 2791071159 @default.
- W2791071159 citedByCount "25" @default.
- W2791071159 countsByYear W27910711592018 @default.