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• W2791106482 abstract "ABSTRACT Resting-state functional MRI (R-fMRI) research has recently entered the era of “big data”, however, few studies have provided a rigorous validation of the physiological underpinnings of R-fMRI indices. Although studies have reported that various neuropsychiatric disorders exhibit abnormalities in R-fMRI measures, these “biomarkers” have not been validated in differentiating structural lesions (brain tumors) as a concept proof. We enrolled 60 patients with intracranial tumors located in the unilateral cranial cavity and 60 matched normal controls to test whether R-fMRI indices can differentiate tumors, which represents a prerequisite for adapting such indices as biomarkers for neuropsychiatric disorders. Common R-fMRI indices of tumors and their counterpart control regions, which were defined as the contralateral normal areas (for amplitude of low frequency fluctuations (ALFF), fractional ALFF (fALFF), regional homogeneity (ReHo) and degree centrality (DC)) and ipsilateral regions surrounding the tumors (for voxel-mirrored homotopic connectivity (VMHC)), were comprehensively assessed. According to paired t -tests with a Bonferroni correction, only ALFF (both with and without Z-standardization) and VMHC (Fisher’s r-to-z transformed) could successfully differentiate substantial tumors from their counterpart normal regions in patients. And DC was not able to differentiate tumor from normal unless employed Z-standardization. To validate the lower power in the between-subject design than in the within-subject design, each metric was calculated in a matched control group, and two-sample t -tests were used to compare the patient tumors and the normal controls at the same area. Only ALFF (and that with Z-standardization) along with VMHC succeeded in differentiating significant differences between tumors and the sham tumors areas of normal controls. This study tested the premise of R-fMRI biomarkers for differentiating lesions, and brings a new understanding to physical significance of the Z-standardization." @default.
• W2791106482 created "2018-03-29" @default.
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• W2791106482 date "2018-03-13" @default.
• W2791106482 modified "2023-10-02" @default.
• W2791106482 title "Physiological Significance of R-fMRI Indices: Can Functional Metrics Differentiate Structural Lesions (Brain Tumors)?" @default.
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• W2791106482 cites W1972691589 @default.
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• W2791106482 cites W1980527160 @default.
• W2791106482 cites W1983834115 @default.
• W2791106482 cites W1984111197 @default.
• W2791106482 cites W1993274235 @default.
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• W2791106482 cites W2004841420 @default.
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• W2791106482 cites W2006739596 @default.
• W2791106482 cites W2007213925 @default.
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• W2791106482 cites W2009494091 @default.
• W2791106482 cites W2011383634 @default.
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• W2791106482 cites W2015895869 @default.
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• W2791106482 cites W2022510542 @default.
• W2791106482 cites W2029132563 @default.
• W2791106482 cites W2036582084 @default.
• W2791106482 cites W2038307665 @default.
• W2791106482 cites W2038618926 @default.
• W2791106482 cites W2039172538 @default.
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• W2791106482 cites W2087374918 @default.
• W2791106482 cites W2093295640 @default.
• W2791106482 cites W2098646031 @default.
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• W2791106482 cites W2145642814 @default.
• W2791106482 cites W2150652656 @default.
• W2791106482 cites W2155298532 @default.
• W2791106482 cites W2157607979 @default.
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• W2791106482 cites W2163444933 @default.
• W2791106482 cites W2167868121 @default.
• W2791106482 cites W2168463527 @default.
• W2791106482 cites W2269908241 @default.
• W2791106482 cites W2310177520 @default.
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• W2791106482 cites W2515271233 @default.
• W2791106482 cites W2522924024 @default.
• W2791106482 cites W2557111525 @default.
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• W2791106482 doi "https://doi.org/10.1101/281352" @default.
• W2791106482 hasPublicationYear "2018" @default.
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