Matches in SemOpenAlex for { <https://semopenalex.org/work/W2791129016> ?p ?o ?g. }
- W2791129016 endingPage "17" @default.
- W2791129016 startingPage "9" @default.
- W2791129016 abstract "Interest in brain-derived neurotrophic factor (BDNF) was greatly enhanced when it was recognized that its expression is reduced in neurodegenerative disorders, especially in Alzheimer's disease (AD). BDNF signaling through the TrkB receptor has a central role in promoting synaptic transmission, synaptogenesis, and facilitating synaptic plasticity making the BDNF-TrkB signaling pathway an attractive candidate for targeted therapies. Here we investigated the early effect of the small molecule TrkB agonist, 7,8 dihydroxyflavone (7,8-DHF), on AD-related pathology, dendritic arborization, synaptic density, and neurochemical changes in the 5xFAD mouse model of AD. We treated 5xFAD mice with 7,8-DHF for 2 months beginning at 1 month of age. We found that, in this model of AD, 7,8-DHF treatment decreased cortical Aβ plaque deposition and protected cortical neurons against reduced dendritic arbor complexity but had no significant impact on the density of dendritic spines. In addition 7,8-DHF treatment protected against hippocampal increase in the level of choline-containing compounds and glutamate loss, but had no significant impact on hippocampal neurogenesis." @default.
- W2791129016 created "2018-03-29" @default.
- W2791129016 creator A5004541689 @default.
- W2791129016 creator A5007677184 @default.
- W2791129016 creator A5010268909 @default.
- W2791129016 creator A5011013725 @default.
- W2791129016 creator A5023351982 @default.
- W2791129016 creator A5027397904 @default.
- W2791129016 creator A5068003167 @default.
- W2791129016 creator A5083836024 @default.
- W2791129016 creator A5086674512 @default.
- W2791129016 date "2018-06-01" @default.
- W2791129016 modified "2023-10-11" @default.
- W2791129016 title "Protective effects of 7,8-dihydroxyflavone on neuropathological and neurochemical changes in a mouse model of Alzheimer's disease" @default.
- W2791129016 cites W1494415215 @default.
- W2791129016 cites W1602778375 @default.
- W2791129016 cites W1769256177 @default.
- W2791129016 cites W1964045660 @default.
- W2791129016 cites W1968973248 @default.
- W2791129016 cites W1977092589 @default.
- W2791129016 cites W1979305117 @default.
- W2791129016 cites W1979702721 @default.
- W2791129016 cites W1982928559 @default.
- W2791129016 cites W1986711579 @default.
- W2791129016 cites W1990752558 @default.
- W2791129016 cites W1997123576 @default.
- W2791129016 cites W1997814051 @default.
- W2791129016 cites W2000310923 @default.
- W2791129016 cites W2002743116 @default.
- W2791129016 cites W2004855983 @default.
- W2791129016 cites W2006733352 @default.
- W2791129016 cites W2012630959 @default.
- W2791129016 cites W2025265926 @default.
- W2791129016 cites W2025563134 @default.
- W2791129016 cites W2043829182 @default.
- W2791129016 cites W2055018912 @default.
- W2791129016 cites W2055723615 @default.
- W2791129016 cites W2055979394 @default.
- W2791129016 cites W2056474574 @default.
- W2791129016 cites W2066110504 @default.
- W2791129016 cites W2068606410 @default.
- W2791129016 cites W2071278571 @default.
- W2791129016 cites W2071481098 @default.
- W2791129016 cites W2071505467 @default.
- W2791129016 cites W2071610467 @default.
- W2791129016 cites W2073283483 @default.
- W2791129016 cites W2082118779 @default.
- W2791129016 cites W2082429191 @default.
- W2791129016 cites W2083840847 @default.
- W2791129016 cites W2086135754 @default.
- W2791129016 cites W2086492737 @default.
- W2791129016 cites W2086504454 @default.
- W2791129016 cites W2102274021 @default.
- W2791129016 cites W2104486619 @default.
- W2791129016 cites W2134483481 @default.
- W2791129016 cites W2136901555 @default.
- W2791129016 cites W2142181595 @default.
- W2791129016 cites W2143834680 @default.
- W2791129016 cites W2143854933 @default.
- W2791129016 cites W2151986987 @default.
- W2791129016 cites W2156326104 @default.
- W2791129016 cites W2157725061 @default.
- W2791129016 cites W2160137568 @default.
- W2791129016 cites W2163116561 @default.
- W2791129016 cites W2165019930 @default.
- W2791129016 cites W2168334242 @default.
- W2791129016 cites W2170644095 @default.
- W2791129016 cites W2181177761 @default.
- W2791129016 cites W2311979663 @default.
- W2791129016 cites W2329336071 @default.
- W2791129016 cites W2337156641 @default.
- W2791129016 cites W2343550771 @default.
- W2791129016 cites W2619776654 @default.
- W2791129016 cites W2751809140 @default.
- W2791129016 cites W2767591112 @default.
- W2791129016 doi "https://doi.org/10.1016/j.ejphar.2018.02.045" @default.
- W2791129016 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5971844" @default.
- W2791129016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29510124" @default.
- W2791129016 hasPublicationYear "2018" @default.
- W2791129016 type Work @default.
- W2791129016 sameAs 2791129016 @default.
- W2791129016 citedByCount "32" @default.
- W2791129016 countsByYear W27911290162018 @default.
- W2791129016 countsByYear W27911290162019 @default.
- W2791129016 countsByYear W27911290162020 @default.
- W2791129016 countsByYear W27911290162021 @default.
- W2791129016 countsByYear W27911290162022 @default.
- W2791129016 countsByYear W27911290162023 @default.
- W2791129016 crossrefType "journal-article" @default.
- W2791129016 hasAuthorship W2791129016A5004541689 @default.
- W2791129016 hasAuthorship W2791129016A5007677184 @default.
- W2791129016 hasAuthorship W2791129016A5010268909 @default.
- W2791129016 hasAuthorship W2791129016A5011013725 @default.
- W2791129016 hasAuthorship W2791129016A5023351982 @default.
- W2791129016 hasAuthorship W2791129016A5027397904 @default.
- W2791129016 hasAuthorship W2791129016A5068003167 @default.
- W2791129016 hasAuthorship W2791129016A5083836024 @default.
- W2791129016 hasAuthorship W2791129016A5086674512 @default.