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• W2791130735 abstract "Anthrax is an era old deadly disease against which there are only two currently available licensed vaccines named Anthrax Vaccine Adsorbed (AVA) and precipitated (AVP). Though they can provide a protective immunity, their multiple side-effects owing to their ill-defined composition and presence of toxic proteins (LF and EF) of Bacillus anthracis, the causative organism of anthrax, in the vaccine formulation makes their widespread use objectionable. Hence, an anthrax vaccine that contains well-defined and controlled components would be highly desirable. In this context, we have evaluated the potential of various vaccine formulations comprising of Protective Antigen (PA) encapsulated trimethyl-chitosan nanoparticles (TMC-PA) in conjunction with either CpG-C ODN 2395(CpG) or Poly I:C. Each formulation was administered via three different routes, viz., subcutaneous (SC), intramuscular (IM) and intraperitoneal (IP) in female BALB/c mice. Irrespective of the route of immunization, CpG or Poly I:C adjuvanted TMC-PA nanoparticles induced a significantly higher humoral response (total serum IgG and its isotypes viz., IgG1, IgG2a, and IgG2b), compared to their CpG or Poly I:C PA counterparts. This clearly demonstrates the synergistic behavior of CpG and Poly I:C with TMC nanoparticles. The adjuvant potential of TMC nanoparticles could be observed in all the three routes as the TMC-PA nanoparticles by themselves induced IgG titers (1-1.5 x105) significantly higher than both CpG PA and Poly I:C PA groups (2-8x104). The effect of formulations on T-helper (Th) cell development was assessed by quantifying the Th1-dependant (TNF-α, IFN-γ, and IL-2), Th2-dependant (IL-4, IL-6, and IL-10) and Th17-type (IL-17A) cytokines. Adjuvanation with CpG and Poly I:C, the TMC-PA nanoparticles triggered a Th1 skewed immune response, as suggested by an increase in the levels of total IgG2a along with IFN-γ cytokine production. Interestingly, the TMC-PA group showed a Th2 biased immune response. Upon challenge with the Bacillus anthracis Ames strain, CpG and Poly I:C adjuvanted TMC-PA nanoparticles immunized via the SC and IM routes showed the highest protective efficacy of ~83%. Altogether the results suggest that CpG or Poly I:C adjuvanted, PA-loaded TMC nanoparticles could be used as an effective, non-toxic, 2nd generation subunit-vaccine candidate against anthrax." @default.
• W2791130735 created "2018-03-29" @default.
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• W2791130735 date "2018-03-20" @default.
• W2791130735 modified "2023-09-30" @default.
• W2791130735 title "Trimethyl Chitosan Nanoparticles Encapsulated Protective Antigen Protects the Mice Against Anthrax" @default.
• W2791130735 cites W1672848901 @default.
• W2791130735 cites W1948268265 @default.
• W2791130735 cites W1950448919 @default.
• W2791130735 cites W195513463 @default.
• W2791130735 cites W1966687184 @default.
• W2791130735 cites W1968977589 @default.
• W2791130735 cites W1975260235 @default.
• W2791130735 cites W1977896525 @default.
• W2791130735 cites W1979971655 @default.
• W2791130735 cites W1988140617 @default.
• W2791130735 cites W1988711597 @default.
• W2791130735 cites W1998989840 @default.
• W2791130735 cites W2001623042 @default.
• W2791130735 cites W2001863331 @default.
• W2791130735 cites W2002246497 @default.
• W2791130735 cites W2008278254 @default.
• W2791130735 cites W2010902096 @default.
• W2791130735 cites W2018506593 @default.
• W2791130735 cites W2018841156 @default.
• W2791130735 cites W2020398834 @default.
• W2791130735 cites W2021021710 @default.
• W2791130735 cites W2022585674 @default.
• W2791130735 cites W2023483341 @default.
• W2791130735 cites W2026162830 @default.
• W2791130735 cites W2027218337 @default.
• W2791130735 cites W2028275623 @default.
• W2791130735 cites W2029173451 @default.
• W2791130735 cites W2029870804 @default.
• W2791130735 cites W2031400762 @default.
• W2791130735 cites W2032496099 @default.
• W2791130735 cites W2032655351 @default.
• W2791130735 cites W2034197799 @default.
• W2791130735 cites W2041852716 @default.
• W2791130735 cites W2042301242 @default.
• W2791130735 cites W2048862104 @default.
• W2791130735 cites W2052817467 @default.
• W2791130735 cites W2057221959 @default.
• W2791130735 cites W2062653165 @default.
• W2791130735 cites W2066442197 @default.
• W2791130735 cites W2072316207 @default.
• W2791130735 cites W2073198693 @default.
• W2791130735 cites W2076361525 @default.
• W2791130735 cites W2077238267 @default.
• W2791130735 cites W2079983241 @default.
• W2791130735 cites W2081663815 @default.
• W2791130735 cites W2097154067 @default.
• W2791130735 cites W2107215997 @default.
• W2791130735 cites W2115533257 @default.
• W2791130735 cites W2117761826 @default.
• W2791130735 cites W2119315539 @default.
• W2791130735 cites W2126244538 @default.
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• W2791130735 doi "https://doi.org/10.3389/fimmu.2018.00562" @default.
• W2791130735 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5870345" @default.
• W2791130735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29616046" @default.
• W2791130735 hasPublicationYear "2018" @default.
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