Matches in SemOpenAlex for { <https://semopenalex.org/work/W2791144662> ?p ?o ?g. }
- W2791144662 endingPage "159" @default.
- W2791144662 startingPage "141" @default.
- W2791144662 abstract "Cysteine cathepsins have been for a long time considered to execute mainly nonspecific bulk proteolysis in the endolysosomal system. However, this view has been changing profoundly over the last decade as cathepsins were found in the cytoplasm, nucleus and in the extracellular milieu. Cathepsins are currently gaining increased attention largely because of their extracellular roles associated with disease development and progression. While kept under tight control under physiological conditions, their dysregulated and elevated activity in the extracellular milieu are distinctive hallmarks of numerous diseases such as various cancers, inflammatory disorders, rheumatoid arthritis, bone disorders and heart diseases. In this review, we discuss cysteine cathepsins with a major focus on their extracellular roles and extracellular proteolytic targets beyond degradation of the extracellular matrix. We further highlight the perspectives of cathepsin research and novel avenues in cathepsin-based diagnostic and therapeutic applications." @default.
- W2791144662 created "2018-03-29" @default.
- W2791144662 creator A5036463770 @default.
- W2791144662 creator A5046721804 @default.
- W2791144662 creator A5056440307 @default.
- W2791144662 date "2019-01-01" @default.
- W2791144662 modified "2023-10-16" @default.
- W2791144662 title "Cysteine cathepsins in extracellular matrix remodeling: Extracellular matrix degradation and beyond" @default.
- W2791144662 cites W1494677644 @default.
- W2791144662 cites W1511307944 @default.
- W2791144662 cites W1515227258 @default.
- W2791144662 cites W1547601942 @default.
- W2791144662 cites W1581436395 @default.
- W2791144662 cites W1762318613 @default.
- W2791144662 cites W1805256772 @default.
- W2791144662 cites W1878275597 @default.
- W2791144662 cites W1884210385 @default.
- W2791144662 cites W1923386801 @default.
- W2791144662 cites W1963664876 @default.
- W2791144662 cites W1964415617 @default.
- W2791144662 cites W1965498876 @default.
- W2791144662 cites W1965682840 @default.
- W2791144662 cites W1965815494 @default.
- W2791144662 cites W1966846792 @default.
- W2791144662 cites W1967644150 @default.
- W2791144662 cites W1967794479 @default.
- W2791144662 cites W1968024679 @default.
- W2791144662 cites W1971971965 @default.
- W2791144662 cites W1973814270 @default.
- W2791144662 cites W1973838563 @default.
- W2791144662 cites W197462632 @default.
- W2791144662 cites W1975200363 @default.
- W2791144662 cites W1976451311 @default.
- W2791144662 cites W1976831807 @default.
- W2791144662 cites W1978414874 @default.
- W2791144662 cites W1989115092 @default.
- W2791144662 cites W1989560280 @default.
- W2791144662 cites W1990328562 @default.
- W2791144662 cites W1990590874 @default.
- W2791144662 cites W1992956105 @default.
- W2791144662 cites W1993079190 @default.
- W2791144662 cites W1994641823 @default.
- W2791144662 cites W1997507909 @default.
- W2791144662 cites W1998705913 @default.
- W2791144662 cites W1998805563 @default.
- W2791144662 cites W1999630747 @default.
- W2791144662 cites W2001027844 @default.
- W2791144662 cites W2001276555 @default.
- W2791144662 cites W2005104593 @default.
- W2791144662 cites W2005298758 @default.
- W2791144662 cites W2005882400 @default.
- W2791144662 cites W2006193439 @default.
- W2791144662 cites W2006899902 @default.
- W2791144662 cites W2007187478 @default.
- W2791144662 cites W2007519641 @default.
- W2791144662 cites W2011229547 @default.
- W2791144662 cites W2011478609 @default.
- W2791144662 cites W2012189423 @default.
- W2791144662 cites W2012845953 @default.
- W2791144662 cites W2013052723 @default.
- W2791144662 cites W2014657897 @default.
- W2791144662 cites W2018614644 @default.
- W2791144662 cites W2018692481 @default.
- W2791144662 cites W2019380853 @default.
- W2791144662 cites W2020914781 @default.
- W2791144662 cites W2022398116 @default.
- W2791144662 cites W2022619943 @default.
- W2791144662 cites W2023026872 @default.
- W2791144662 cites W2023284187 @default.
- W2791144662 cites W2023641472 @default.
- W2791144662 cites W2024583791 @default.
- W2791144662 cites W2025114711 @default.
- W2791144662 cites W2025381786 @default.
- W2791144662 cites W2027110730 @default.
- W2791144662 cites W2027345832 @default.
- W2791144662 cites W2029322891 @default.
- W2791144662 cites W2030340060 @default.
- W2791144662 cites W2033025094 @default.
- W2791144662 cites W2033390322 @default.
- W2791144662 cites W2033873241 @default.
- W2791144662 cites W2033927694 @default.
- W2791144662 cites W2035681182 @default.
- W2791144662 cites W2035683946 @default.
- W2791144662 cites W2035974720 @default.
- W2791144662 cites W2038422579 @default.
- W2791144662 cites W2039572697 @default.
- W2791144662 cites W2041373561 @default.
- W2791144662 cites W2041617023 @default.
- W2791144662 cites W2044365478 @default.
- W2791144662 cites W2044835152 @default.
- W2791144662 cites W2046359578 @default.
- W2791144662 cites W2048626511 @default.
- W2791144662 cites W2048757824 @default.
- W2791144662 cites W2049644040 @default.
- W2791144662 cites W2049891971 @default.
- W2791144662 cites W2050725355 @default.
- W2791144662 cites W2052218939 @default.
- W2791144662 cites W2054462619 @default.