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• W2791170126 abstract "Intervention with dietary fibers is an important strategy to combat the global epidemic of obesity which is a consequence of energy imbalance. However, a possible role of the gut microbiota in effects of dietary fibers on energy homeostasis remains unclear. Here, we treated a high fat diet-induced obese (DIO) mouse model with soluble dietary fiber. Our results showed that soluble dietary fiber reduced body weight gain and the excessive accumulation of white fat tissue in DIO mice. Notably, soluble dietary fiber increased energy expenditure, but not change energy intake in DIO mice. In accordance, 16S rRNA sequencing revealed that the diversity of the gut microbiota was restored by soluble dietary fiber. Moreover, compared with controls, soluble dietary fiber resulted in a decreased ratio of Firmicutes/Bacteroidetes at the phylum level, and an increased relative abundance of the genera Roseburia at the genus level. Taken together, these findings indicate that soluble dietary fiber improves energy homeostasis and prevents obesity by increasing the diversity of the gut microbiota and the colonization of beneficial bacteria." @default.
• W2791170126 created "2018-03-29" @default.
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• W2791170126 date "2018-03-01" @default.
• W2791170126 modified "2023-10-11" @default.
• W2791170126 title "Soluble dietary fiber improves energy homeostasis in obese mice by remodeling the gut microbiota" @default.
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• W2791170126 doi "https://doi.org/10.1016/j.bbrc.2018.02.017" @default.
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