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- W2791190834 endingPage "153" @default.
- W2791190834 startingPage "143" @default.
- W2791190834 abstract "Head and neck squamous cell carcinomas (HNSCC) are in a group of cancers that are the most resistant to treatment. The survival rate of HNSCC patients has been still very low since last 20 years. The existence of relationship between oncogenic and surrounding cells is probably the reason for a poor response to treatment. Fibroblasts are an important element of tumor stroma which increases tumor cells ability to proliferate. Another highly resistance, tumorigenic and metastatic cell population in tumor microenvironment are cancer initiating cells (CICs). The population of cancer initiating cells can be found regardless of differentiation status of cancer and they seem to be crucial for HNSCC development. In this review, we describe the current state of knowledge about HNSCC biological and physiological tumor microenvironment." @default.
- W2791190834 created "2018-03-29" @default.
- W2791190834 creator A5011901659 @default.
- W2791190834 creator A5033521089 @default.
- W2791190834 creator A5036859870 @default.
- W2791190834 creator A5039797494 @default.
- W2791190834 creator A5041738551 @default.
- W2791190834 creator A5059554540 @default.
- W2791190834 creator A5071937365 @default.
- W2791190834 date "2018-05-01" @default.
- W2791190834 modified "2023-10-16" @default.
- W2791190834 title "Tumor microenvironment – Unknown niche with powerful therapeutic potential" @default.
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