FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2791236986> ?p ?o ?g. }

• W2791236986 abstract "Abstract Obesity is a growing public health problem that increases rates of white matter atrophy and increases the likelihood of ischemic lesions within white matter. However, the cellular and molecular mechanisms that regulate these changes are unknown. We hypothesized that obesity may alter oligodendrocytes and myelin priming white matter for worsening injury and repair responses after ischemia. C57Bl/6 mice fed a high fat diet (60% kcal from fat) show increased numbers of oligodendrocyte precursor cells (OPCs), decreased myelin thickness with elevated g-ratios, and shorter paranodal axonal segments, indicating accelerated myelin turnover. Fate mapping of OPCs in PDGFRα-Cre ERT ;Rpl22 tm1.1Psam mice demonstrated that OPC differentiation rates are enhanced by obesity. Gene expression analyses using a novel oligodendrocyte staging assay demonstrated OPC differentiation is blocked by obesity in between the pre-myelinating and myelinating stage. Using a model of subcortical white matter stroke, the number of stroke-responsive OPCs in obese mice was increased after stroke. At early time points after ischemic white matter stroke, spatial mapping of stroke-responsive OPCs indicates that obesity leads to increased OPCs at the edge of ischemic white matter lesions. At later time points, obesity results in increased OPCs within the ischemic lesion while reducing the number of GST-π-positive mature oligodendrocytes in the lesion core. These data indicate that obesity disrupts normal white matter biology by blocking oligodendrocyte differentiation, leads to an exaggerated response of OPCs to white matter ischemia, and limits remyelination after stroke. Significance Statement Obesity is a growing public health crisis that specifically increases the development of white matter lesions and silent brain infarcts. This relationship implies a direct cellular effect on white matter yet direct evidence is limited. We modeled diet-induced obesity in mice and studied the effect on oligodendrocyte biology and the response to focal white matter stroke. Adult-onset obesity results in thinner myelin, compromised axonal microdomain structure, and blocks the differentiation of OPCs, leaving the white matter with increased numbers of OPCs. After focal white matter stroke in obese mice, the early OPC response to stroke is exaggerated while late reparative OPC differentiation is blocked. These results suggest that obesity specifically blocks OPC differentiation with consequence on brain repair after stroke." @default.
• W2791236986 created "2018-03-29" @default.
• W2791236986 creator A5020468723 @default.
• W2791236986 creator A5036614911 @default.
• W2791236986 creator A5042075080 @default.
• W2791236986 creator A5053743900 @default.
• W2791236986 creator A5065465113 @default.
• W2791236986 date "2018-03-23" @default.
• W2791236986 modified "2023-09-26" @default.
• W2791236986 title "Obesity blocks oligodendrocyte precursor cell differentiation and impedes repair after white matter stroke" @default.
• W2791236986 cites W1704561002 @default.
• W2791236986 cites W1921871464 @default.
• W2791236986 cites W1964928356 @default.
• W2791236986 cites W1972508873 @default.
• W2791236986 cites W1979552960 @default.
• W2791236986 cites W1985286185 @default.
• W2791236986 cites W1991502302 @default.
• W2791236986 cites W1996120720 @default.
• W2791236986 cites W1997038422 @default.
• W2791236986 cites W1998292074 @default.
• W2791236986 cites W2002667055 @default.
• W2791236986 cites W2005691028 @default.
• W2791236986 cites W2015602829 @default.
• W2791236986 cites W2027427622 @default.
• W2791236986 cites W2042535492 @default.
• W2791236986 cites W2050736309 @default.
• W2791236986 cites W2054221968 @default.
• W2791236986 cites W2054275187 @default.
• W2791236986 cites W2055264753 @default.
• W2791236986 cites W2062793260 @default.
• W2791236986 cites W2065123450 @default.
• W2791236986 cites W2070050178 @default.
• W2791236986 cites W2072290762 @default.
• W2791236986 cites W2072528436 @default.
• W2791236986 cites W2074160345 @default.
• W2791236986 cites W2074978325 @default.
• W2791236986 cites W2080141893 @default.
• W2791236986 cites W2080467864 @default.
• W2791236986 cites W2085442517 @default.
• W2791236986 cites W2099511111 @default.
• W2791236986 cites W2103240729 @default.
• W2791236986 cites W2120683729 @default.
• W2791236986 cites W2127208829 @default.
• W2791236986 cites W2129082205 @default.
• W2791236986 cites W2129150286 @default.
• W2791236986 cites W2131394474 @default.
• W2791236986 cites W2133188899 @default.
• W2791236986 cites W2144096099 @default.
• W2791236986 cites W2145490597 @default.
• W2791236986 cites W2147788805 @default.
• W2791236986 cites W2150929583 @default.
• W2791236986 cites W2159029645 @default.
• W2791236986 cites W2164913239 @default.
• W2791236986 cites W2164942167 @default.
• W2791236986 cites W2166419090 @default.
• W2791236986 cites W2167279371 @default.
• W2791236986 cites W2273567156 @default.
• W2791236986 cites W2301771266 @default.
• W2791236986 cites W2345356016 @default.
• W2791236986 cites W2561139731 @default.
• W2791236986 cites W2663849558 @default.
• W2791236986 cites W2751178109 @default.
• W2791236986 cites W971655283 @default.
• W2791236986 doi "https://doi.org/10.1101/283184" @default.
• W2791236986 hasPublicationYear "2018" @default.
• W2791236986 type Work @default.
• W2791236986 sameAs 2791236986 @default.
• W2791236986 citedByCount "4" @default.
• W2791236986 countsByYear W27912369862019 @default.
• W2791236986 countsByYear W27912369862021 @default.
• W2791236986 countsByYear W27912369862022 @default.
• W2791236986 crossrefType "posted-content" @default.
• W2791236986 hasAuthorship W2791236986A5020468723 @default.
• W2791236986 hasAuthorship W2791236986A5036614911 @default.
• W2791236986 hasAuthorship W2791236986A5042075080 @default.
• W2791236986 hasAuthorship W2791236986A5053743900 @default.
• W2791236986 hasAuthorship W2791236986A5065465113 @default.
• W2791236986 hasBestOaLocation W27912369861 @default.
• W2791236986 hasConcept C126322002 @default.
• W2791236986 hasConcept C126838900 @default.
• W2791236986 hasConcept C127413603 @default.
• W2791236986 hasConcept C134018914 @default.
• W2791236986 hasConcept C142724271 @default.
• W2791236986 hasConcept C143409427 @default.
• W2791236986 hasConcept C169760540 @default.
• W2791236986 hasConcept C2776985911 @default.
• W2791236986 hasConcept C2777619251 @default.
• W2791236986 hasConcept C2778609137 @default.
• W2791236986 hasConcept C2780645631 @default.
• W2791236986 hasConcept C2781156865 @default.
• W2791236986 hasConcept C2781192897 @default.
• W2791236986 hasConcept C529278444 @default.
• W2791236986 hasConcept C541997718 @default.
• W2791236986 hasConcept C71924100 @default.
• W2791236986 hasConcept C78519656 @default.
• W2791236986 hasConcept C86803240 @default.
• W2791236986 hasConceptScore W2791236986C126322002 @default.
• W2791236986 hasConceptScore W2791236986C126838900 @default.
• W2791236986 hasConceptScore W2791236986C127413603 @default.
• W2791236986 hasConceptScore W2791236986C134018914 @default.

• next