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• W2791294487 endingPage "e0006311" @default.
• W2791294487 startingPage "e0006311" @default.
• W2791294487 abstract "Rabies is a fatal neurologic disease caused by lyssavirus infection. People are infected through contact with infected animals. The relative increase of human rabies acquired from bats calls for a better understanding of lyssavirus infections in their natural hosts. So far, there is no experimental model that mimics natural lyssavirus infection in the reservoir bat species. Lagos bat virus is a lyssavirus that is endemic in straw-colored fruit bats (Eidolon helvum) in Africa. Here we compared the susceptibility of these bats to three strains of Lagos bat virus (from Senegal, Nigeria, and Ghana) by intracranial inoculation. To allow comparison between strains, we ensured the same titer of virus was inoculated in the same location of the brain of each bat. All bats (n = 3 per strain) were infected, and developed neurological signs, and fatal meningoencephalitis with lyssavirus antigen expression in neurons. There were three main differences among the groups. First, time to death was substantially shorter in the Senegal and Ghana groups (4 to 6 days) than in the Nigeria group (8 days). Second, each virus strain produced a distinct clinical syndrome. Third, the spread of virus to peripheral tissues, tested by hemi-nested reverse transcriptase PCR, was frequent (3 of 3 bats) and widespread (8 to 10 tissues positive of 11 tissues examined) in the Ghana group, was frequent and less widespread in the Senegal group (3/3 bats, 3 to 6 tissues positive), and was rare and restricted in the Nigeria group (1/3 bats, 2 tissues positive). Centrifugal spread of virus from brain to tissue of excretion in the oral cavity is required to enable lyssavirus transmission. Therefore, the Senegal and Ghana strains seem most suitable for further pathogenesis, and for transmission, studies in the straw-colored fruit bat." @default.
• W2791294487 created "2018-03-29" @default.
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• W2791294487 date "2018-03-05" @default.
• W2791294487 modified "2023-10-09" @default.
• W2791294487 title "Pathogenesis of bat rabies in a natural reservoir: Comparative susceptibility of the straw-colored fruit bat (Eidolon helvum) to three strains of Lagos bat virus" @default.
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• W2791294487 cites W1967510545 @default.
• W2791294487 cites W1970458186 @default.
• W2791294487 cites W1973455077 @default.
• W2791294487 cites W1974950151 @default.
• W2791294487 cites W1987422838 @default.
• W2791294487 cites W1990193311 @default.
• W2791294487 cites W1999997552 @default.
• W2791294487 cites W2000078218 @default.
• W2791294487 cites W2002849167 @default.
• W2791294487 cites W2006159814 @default.
• W2791294487 cites W2007978374 @default.
• W2791294487 cites W2012076682 @default.
• W2791294487 cites W2015938873 @default.
• W2791294487 cites W2015985276 @default.
• W2791294487 cites W2018356836 @default.
• W2791294487 cites W2018671392 @default.
• W2791294487 cites W2024419055 @default.
• W2791294487 cites W2024620762 @default.
• W2791294487 cites W2025924425 @default.
• W2791294487 cites W2028612204 @default.
• W2791294487 cites W2033846027 @default.
• W2791294487 cites W2036742353 @default.
• W2791294487 cites W2038808510 @default.
• W2791294487 cites W2040046438 @default.
• W2791294487 cites W2051645210 @default.
• W2791294487 cites W2067373557 @default.
• W2791294487 cites W2071833318 @default.
• W2791294487 cites W2073034493 @default.
• W2791294487 cites W2078786804 @default.
• W2791294487 cites W2079973434 @default.
• W2791294487 cites W2087496505 @default.
• W2791294487 cites W2088341819 @default.
• W2791294487 cites W2091436727 @default.
• W2791294487 cites W2099668563 @default.
• W2791294487 cites W2101708888 @default.
• W2791294487 cites W2103862627 @default.
• W2791294487 cites W2104523320 @default.
• W2791294487 cites W2107597477 @default.
• W2791294487 cites W2108904325 @default.
• W2791294487 cites W2113072213 @default.
• W2791294487 cites W2113976597 @default.
• W2791294487 cites W2119684762 @default.
• W2791294487 cites W2122010425 @default.
• W2791294487 cites W2128179462 @default.
• W2791294487 cites W2131863144 @default.
• W2791294487 cites W2138512401 @default.
• W2791294487 cites W2141383027 @default.
• W2791294487 cites W2147868481 @default.
• W2791294487 cites W2150093755 @default.
• W2791294487 cites W2154541543 @default.
• W2791294487 cites W2155314993 @default.
• W2791294487 cites W2156800615 @default.
• W2791294487 cites W2158497519 @default.
• W2791294487 cites W2159504662 @default.
• W2791294487 cites W2160744322 @default.
• W2791294487 cites W2161624251 @default.
• W2791294487 cites W2161710659 @default.
• W2791294487 cites W2169242258 @default.
• W2791294487 cites W2281725364 @default.
• W2791294487 cites W2323959772 @default.
• W2791294487 cites W2335193323 @default.
• W2791294487 cites W2411733748 @default.
• W2791294487 cites W2418303782 @default.
• W2791294487 cites W929130323 @default.
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• W2791294487 doi "https://doi.org/10.1371/journal.pntd.0006311" @default.
• W2791294487 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5854431" @default.
• W2791294487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29505617" @default.

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