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- W2791338963 abstract "Crucial steps in the miniaturization of biosensors are the conversion of a biological signal into an electrical current as well as the direct sampling of biological fluids. Here we show that protein sensors in combination with a biological nanopore Cytolysin A (ClyA), acting as an electrical transducer, can accurately quantify metabolites from tiny amounts of bodily fluids with internalized substrate binding proteins (SBDs). The single-molecule nature of the sensor allows continuous sampling of multiple analytes simultaneously without the need of calibration for signal drift. Crucially, no adverse effects of other analytes in the bodily fluids tested could be discerned as the nanopore act as a nanoscale molecular filter, allowing direct sampling of small volumes of biological samples with no sample preparation. Incorporation of the nanopore into portable electronic devices will allow developing sensitive, continuous and non-invasive sensors for hundreds of metabolites for point-of-care, home diagnostics and wearable devices." @default.
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- W2791338963 date "2018-02-01" @default.
- W2791338963 modified "2023-09-30" @default.
- W2791338963 title "Direct Quantification of Metabolites from Bodily Fluids using Nanopores" @default.
- W2791338963 doi "https://doi.org/10.1016/j.bpj.2017.11.3712" @default.
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