FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2791362600> ?p ?o ?g. }

• W2791362600 endingPage "205" @default.
• W2791362600 startingPage "198" @default.
• W2791362600 abstract "The purpose of present investigation was to nano-encapsulate atypical antipsychotic such as Olanzapine in polymeric nanoparticles in order to explore the possibility of minimizing drug associated extrapyramidal adverse effects. The polymeric nanoparticulate systems were prepared using FDA approved polymer, polycaprolactone, by simple technique of nanoprecipitation using factorial design by DoE approach. The significant factors selected for the optimization during formulation development process were polymer content and surfactant concentration at three different levels (32 factorial design). The effect of selected significant factors were studied in depth on significant responses such as particle size and encapsulation efficiency. The optimized formulation was further surface modified with surfactant (polysorbate 80) so as to enhance the brain targeting efficiency of developed nanoparticles via endocytosis pathway. Furthermore, catalepsy was induced in rodent model and the designed formulations were investigated in comparison with pure drug solution for efficiency in decreasing extrapyramidal adverse effects. The results of in vitro characterization studies demonstrated a narrow size distributed nanoparticles (73.28 ± 2.14 nm) with high stability indicating zetapotential (−32.46 ± 1.15 mV) and high encapsulation efficiency (78.77 ± 2.83%). In vitro release studies resulted in an extended release of atypical antipsychotic for 60 h from drug-loaded optimized nanoparticulate formulations. The catalepsy studies in rodent model demonstrated a significant decrease in extra pyramidal adverse effects as compared to the pure atypical antipsychotic. Thus, the designed antipsychotic loaded polymeric nanoparticulate system may be highly promising for the tremendous improvement of antipsychotic therapy with reduced adverse effects." @default.
• W2791362600 created "2018-03-29" @default.
• W2791362600 creator A5000092676 @default.
• W2791362600 creator A5022545051 @default.
• W2791362600 creator A5071612572 @default.
• W2791362600 creator A5077904567 @default.
• W2791362600 creator A5082703526 @default.
• W2791362600 date "2018-04-01" @default.
• W2791362600 modified "2023-10-12" @default.
• W2791362600 title "DoE based Olanzapine loaded poly-caprolactone nanoparticles decreases extrapyramidal effects in rodent model" @default.
• W2791362600 cites W1604217211 @default.
• W2791362600 cites W1977755432 @default.
• W2791362600 cites W1986345142 @default.
• W2791362600 cites W1986484493 @default.
• W2791362600 cites W1987608027 @default.
• W2791362600 cites W1988652094 @default.
• W2791362600 cites W1995601667 @default.
• W2791362600 cites W2015476361 @default.
• W2791362600 cites W2020975942 @default.
• W2791362600 cites W2021946861 @default.
• W2791362600 cites W2046017386 @default.
• W2791362600 cites W2047414721 @default.
• W2791362600 cites W2054189154 @default.
• W2791362600 cites W2054975235 @default.
• W2791362600 cites W2064402334 @default.
• W2791362600 cites W2072954285 @default.
• W2791362600 cites W2078327498 @default.
• W2791362600 cites W2083782393 @default.
• W2791362600 cites W2094965977 @default.
• W2791362600 cites W2104009433 @default.
• W2791362600 cites W2124183927 @default.
• W2791362600 cites W2129321699 @default.
• W2791362600 cites W2136472480 @default.
• W2791362600 cites W2138281910 @default.
• W2791362600 cites W2142404968 @default.
• W2791362600 cites W2143913225 @default.
• W2791362600 cites W2145602532 @default.
• W2791362600 cites W2152770536 @default.
• W2791362600 cites W2154043786 @default.
• W2791362600 cites W2327669759 @default.
• W2791362600 cites W2562675813 @default.
• W2791362600 cites W2606662217 @default.
• W2791362600 cites W4230908322 @default.
• W2791362600 doi "https://doi.org/10.1016/j.ijpharm.2018.02.010" @default.
• W2791362600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29474898" @default.
• W2791362600 hasPublicationYear "2018" @default.
• W2791362600 type Work @default.
• W2791362600 sameAs 2791362600 @default.
• W2791362600 citedByCount "19" @default.
• W2791362600 countsByYear W27913626002018 @default.
• W2791362600 countsByYear W27913626002019 @default.
• W2791362600 countsByYear W27913626002020 @default.
• W2791362600 countsByYear W27913626002021 @default.
• W2791362600 countsByYear W27913626002022 @default.
• W2791362600 countsByYear W27913626002023 @default.
• W2791362600 crossrefType "journal-article" @default.
• W2791362600 hasAuthorship W2791362600A5000092676 @default.
• W2791362600 hasAuthorship W2791362600A5022545051 @default.
• W2791362600 hasAuthorship W2791362600A5071612572 @default.
• W2791362600 hasAuthorship W2791362600A5077904567 @default.
• W2791362600 hasAuthorship W2791362600A5082703526 @default.
• W2791362600 hasConcept C105795698 @default.
• W2791362600 hasConcept C118552586 @default.
• W2791362600 hasConcept C134018914 @default.
• W2791362600 hasConcept C147789679 @default.
• W2791362600 hasConcept C155672457 @default.
• W2791362600 hasConcept C169222746 @default.
• W2791362600 hasConcept C171250308 @default.
• W2791362600 hasConcept C185592680 @default.
• W2791362600 hasConcept C187530423 @default.
• W2791362600 hasConcept C192562407 @default.
• W2791362600 hasConcept C2776412080 @default.
• W2791362600 hasConcept C2776619155 @default.
• W2791362600 hasConcept C2776921671 @default.
• W2791362600 hasConcept C2780476085 @default.
• W2791362600 hasConcept C2780494398 @default.
• W2791362600 hasConcept C2780616385 @default.
• W2791362600 hasConcept C2780948584 @default.
• W2791362600 hasConcept C33923547 @default.
• W2791362600 hasConcept C513476851 @default.
• W2791362600 hasConcept C55493867 @default.
• W2791362600 hasConcept C58226133 @default.
• W2791362600 hasConcept C71924100 @default.
• W2791362600 hasConcept C98274493 @default.
• W2791362600 hasConceptScore W2791362600C105795698 @default.
• W2791362600 hasConceptScore W2791362600C118552586 @default.
• W2791362600 hasConceptScore W2791362600C134018914 @default.
• W2791362600 hasConceptScore W2791362600C147789679 @default.
• W2791362600 hasConceptScore W2791362600C155672457 @default.
• W2791362600 hasConceptScore W2791362600C169222746 @default.
• W2791362600 hasConceptScore W2791362600C171250308 @default.
• W2791362600 hasConceptScore W2791362600C185592680 @default.
• W2791362600 hasConceptScore W2791362600C187530423 @default.
• W2791362600 hasConceptScore W2791362600C192562407 @default.
• W2791362600 hasConceptScore W2791362600C2776412080 @default.
• W2791362600 hasConceptScore W2791362600C2776619155 @default.
• W2791362600 hasConceptScore W2791362600C2776921671 @default.
• W2791362600 hasConceptScore W2791362600C2780476085 @default.

• next