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- W2791391969 abstract "Somatic mutations are postzygotic mutations which may lead to mosaicism, the presence of cells with genetic differences in an organism. Their role in cancer is well established, but detailed investigation in health and other diseases has only been recently possible. This has been empowered by the improvements of sequencing techniques, including single‐cell sequencing, which can still be error‐prone but is rapidly improving. Mosaicism appears relatively common in the human body, including the normal brain, probably arising in early development, but also potentially during ageing. In this review, we first discuss theoretical considerations and current evidence relevant to somatic mutations in the brain. We present a framework to explain how they may be integrated with current views on neurodegeneration, focusing mainly on sporadic late‐onset neurodegenerative diseases (Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis). We review the relevant studies so far, with the first evidence emerging in Alzheimer's in particular. We also discuss the role of mosaicism in inherited neurodegenerative disorders, particularly somatic instability of tandem repeats. We summarize existing views and data to present a model whereby the time of origin and spatial distribution of relevant somatic mutations, combined with any additional risk factors, may partly determine the development and onset age of sporadic neurodegenerative diseases." @default.
- W2791391969 created "2018-03-29" @default.
- W2791391969 creator A5012157016 @default.
- W2791391969 creator A5014838229 @default.
- W2791391969 creator A5057842213 @default.
- W2791391969 date "2018-02-28" @default.
- W2791391969 modified "2023-10-18" @default.
- W2791391969 title "Review: Somatic mutations in neurodegeneration" @default.
- W2791391969 cites W1045959496 @default.
- W2791391969 cites W1120256502 @default.
- W2791391969 cites W1485516614 @default.
- W2791391969 cites W1494866131 @default.
- W2791391969 cites W1508563209 @default.
- W2791391969 cites W1508644246 @default.
- W2791391969 cites W1546304837 @default.
- W2791391969 cites W1550772509 @default.
- W2791391969 cites W1576762681 @default.
- W2791391969 cites W1601755300 @default.
- W2791391969 cites W1758544898 @default.
- W2791391969 cites W1789457561 @default.
- W2791391969 cites W1856124239 @default.
- W2791391969 cites W1964013868 @default.
- W2791391969 cites W1970292439 @default.
- W2791391969 cites W1971352742 @default.
- W2791391969 cites W1972615369 @default.
- W2791391969 cites W1973319971 @default.
- W2791391969 cites W1975466959 @default.
- W2791391969 cites W1979879639 @default.
- W2791391969 cites W1981749204 @default.
- W2791391969 cites W1984993302 @default.
- W2791391969 cites W1985039849 @default.
- W2791391969 cites W1989280457 @default.
- W2791391969 cites W1996637092 @default.
- W2791391969 cites W1996650107 @default.
- W2791391969 cites W1997127728 @default.
- W2791391969 cites W1997873648 @default.
- W2791391969 cites W2001994785 @default.
- W2791391969 cites W2004030615 @default.
- W2791391969 cites W2005742709 @default.
- W2791391969 cites W2007326275 @default.
- W2791391969 cites W2011816180 @default.
- W2791391969 cites W2012158181 @default.
- W2791391969 cites W2014541905 @default.
- W2791391969 cites W2015236057 @default.
- W2791391969 cites W2015487969 @default.
- W2791391969 cites W2016493477 @default.
- W2791391969 cites W2018183872 @default.
- W2791391969 cites W2018530963 @default.
- W2791391969 cites W2022102389 @default.
- W2791391969 cites W2023095530 @default.
- W2791391969 cites W2023598911 @default.
- W2791391969 cites W2025224836 @default.
- W2791391969 cites W2025251914 @default.
- W2791391969 cites W2025277965 @default.
- W2791391969 cites W2026709018 @default.
- W2791391969 cites W2031081876 @default.
- W2791391969 cites W2032679533 @default.
- W2791391969 cites W2037930474 @default.
- W2791391969 cites W2040716080 @default.
- W2791391969 cites W2041742383 @default.
- W2791391969 cites W2041964860 @default.
- W2791391969 cites W2045512059 @default.
- W2791391969 cites W2047158979 @default.
- W2791391969 cites W2050591302 @default.
- W2791391969 cites W2053493373 @default.
- W2791391969 cites W2054553729 @default.
- W2791391969 cites W2055798820 @default.
- W2791391969 cites W2056079743 @default.
- W2791391969 cites W2056189848 @default.
- W2791391969 cites W2056895564 @default.
- W2791391969 cites W2057808647 @default.
- W2791391969 cites W2060895356 @default.
- W2791391969 cites W2061794007 @default.
- W2791391969 cites W2063392648 @default.
- W2791391969 cites W2066803056 @default.
- W2791391969 cites W2071026538 @default.
- W2791391969 cites W2071536472 @default.
- W2791391969 cites W2074089003 @default.
- W2791391969 cites W2076781430 @default.
- W2791391969 cites W2076843947 @default.
- W2791391969 cites W2080053685 @default.
- W2791391969 cites W2082019169 @default.
- W2791391969 cites W2084271883 @default.
- W2791391969 cites W2086663462 @default.
- W2791391969 cites W2087316628 @default.
- W2791391969 cites W2088470456 @default.
- W2791391969 cites W2092598865 @default.
- W2791391969 cites W2098342116 @default.
- W2791391969 cites W2100591042 @default.
- W2791391969 cites W2105970624 @default.
- W2791391969 cites W2106663689 @default.
- W2791391969 cites W2109456034 @default.
- W2791391969 cites W2109880206 @default.
- W2791391969 cites W2111747321 @default.
- W2791391969 cites W2111820284 @default.
- W2791391969 cites W2112451788 @default.
- W2791391969 cites W2119742125 @default.
- W2791391969 cites W2122673932 @default.