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- W2791401348 endingPage "140" @default.
- W2791401348 startingPage "140" @default.
- W2791401348 abstract "Ammonia is constantly produced as a metabolic waste from amino acid catabolism in mammals. Ammonia, the toxic waste metabolite, is resolved in the liver where the urea cycle converts free ammonia to urea. Liver malfunctions cause hyperammonemia that leads to central nervous system (CNS) dysfunctions, such as brain edema, convulsions, and coma. The current treatments for hyperammonemia, such as antibiotics or lactulose, are designed to decrease the intestinal production of ammonia and/or its absorption into the body and are not effective, besides being often accompanied by side effects. In recent years, increasing evidence has shown that modifications of the gut microbiota could be used to treat hyperammonemia. Considering the role of the gut microbiota and the physiological characteristics of the intestine, the removal of ammonia from the intestine by modulating the gut microbiota would be an ideal approach to treat hyperammonemia. In this review, we discuss the significance of hyperammonemia and its related diseases and the efficacy of the current management methods for hyperammonemia to understand the mechanism of ammonia transport in the human body. The possibility to use the gut microbiota as pharmabiotics to treat hyperammonemia and its related diseases is also explored." @default.
- W2791401348 created "2018-03-29" @default.
- W2791401348 creator A5006489078 @default.
- W2791401348 creator A5009738907 @default.
- W2791401348 creator A5017359833 @default.
- W2791401348 creator A5040436508 @default.
- W2791401348 creator A5050544454 @default.
- W2791401348 date "2018-01-28" @default.
- W2791401348 modified "2023-10-13" @default.
- W2791401348 title "The Pharmabiotic Approach to Treat Hyperammonemia" @default.
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