Matches in SemOpenAlex for { <https://semopenalex.org/work/W2791448816> ?p ?o ?g. }
- W2791448816 endingPage "262" @default.
- W2791448816 startingPage "253" @default.
- W2791448816 abstract "BackgroundAlthough the impact of the microphthalamia-associated transcription factor (Mitf) signaling pathway on melanocytes progression has been extensively studied, the specific molecular mechanisms behind MITF-M-enhanced melanin production in melanocytes still need to be clarified.MethodsIn this study, we analyzed the levels of Mitf-M in skin tissues of different coat mice in order to further reveal the relationship between Mitf-M and skin pigmentation. To address the function of Mitf-M on melanogenesis, we have used an overexpression system and combined morphological and biochemical methods to investigate its localization in different coat color mice and pigmentation-related genes’ expression in mouse melanocytes.ResultsThe qRT-PCR assay and Western blotting analysis revealed that Mitf-M mRNA and protein were synthesized in all tested mice skin samples, with the highest expression level in brown skin, a moderate expression level in grey skin and the lowest expression level in black skin. Simultaneously, immunofluorescence staining revealed that MITF-M was mainly expressed in the hair follicle matrix and inner and outer root sheath in the skin tissues with different coat colors. Furthermore, overexpression of MITF-M led to increased melanin content and variable pigmentation-related gene expression.ConclusionThese results directly demonstrate that MITF-M not only influences melanogenesis, but also determines the progression of melanosomal protein in mouse melanocytes." @default.
- W2791448816 created "2018-03-29" @default.
- W2791448816 creator A5000341131 @default.
- W2791448816 creator A5009263498 @default.
- W2791448816 creator A5029246125 @default.
- W2791448816 creator A5044752020 @default.
- W2791448816 creator A5052323062 @default.
- W2791448816 creator A5088477455 @default.
- W2791448816 creator A5090739101 @default.
- W2791448816 date "2018-06-01" @default.
- W2791448816 modified "2023-09-27" @default.
- W2791448816 title "MITF-M regulates melanogenesis in mouse melanocytes" @default.
- W2791448816 cites W1487917997 @default.
- W2791448816 cites W1556001751 @default.
- W2791448816 cites W1595732636 @default.
- W2791448816 cites W1657719429 @default.
- W2791448816 cites W1883936019 @default.
- W2791448816 cites W1919489047 @default.
- W2791448816 cites W1965644724 @default.
- W2791448816 cites W1968348164 @default.
- W2791448816 cites W1972091291 @default.
- W2791448816 cites W1979420492 @default.
- W2791448816 cites W1982635732 @default.
- W2791448816 cites W1988241422 @default.
- W2791448816 cites W1988361924 @default.
- W2791448816 cites W1990005278 @default.
- W2791448816 cites W2015721987 @default.
- W2791448816 cites W2019886235 @default.
- W2791448816 cites W2020183718 @default.
- W2791448816 cites W2020662754 @default.
- W2791448816 cites W2022209206 @default.
- W2791448816 cites W2022971865 @default.
- W2791448816 cites W2023764466 @default.
- W2791448816 cites W2032924812 @default.
- W2791448816 cites W2037104940 @default.
- W2791448816 cites W2039079800 @default.
- W2791448816 cites W2041497209 @default.
- W2791448816 cites W2045560488 @default.
- W2791448816 cites W2050991107 @default.
- W2791448816 cites W2053011686 @default.
- W2791448816 cites W2056355153 @default.
- W2791448816 cites W2056859782 @default.
- W2791448816 cites W2059169513 @default.
- W2791448816 cites W2064450926 @default.
- W2791448816 cites W2064904666 @default.
- W2791448816 cites W2067134023 @default.
- W2791448816 cites W2072657606 @default.
- W2791448816 cites W2084566002 @default.
- W2791448816 cites W2101499880 @default.
- W2791448816 cites W2104146535 @default.
- W2791448816 cites W2105224026 @default.
- W2791448816 cites W2118552809 @default.
- W2791448816 cites W2124214914 @default.
- W2791448816 cites W2125842849 @default.
- W2791448816 cites W2126638912 @default.
- W2791448816 cites W2126945805 @default.
- W2791448816 cites W2139296639 @default.
- W2791448816 cites W2144809232 @default.
- W2791448816 cites W2145297890 @default.
- W2791448816 cites W2147122728 @default.
- W2791448816 cites W2150520945 @default.
- W2791448816 cites W2150935517 @default.
- W2791448816 cites W2152321720 @default.
- W2791448816 cites W2165377430 @default.
- W2791448816 cites W2211478793 @default.
- W2791448816 cites W2526318276 @default.
- W2791448816 cites W4250635458 @default.
- W2791448816 doi "https://doi.org/10.1016/j.jdermsci.2018.02.008" @default.
- W2791448816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29496358" @default.
- W2791448816 hasPublicationYear "2018" @default.
- W2791448816 type Work @default.
- W2791448816 sameAs 2791448816 @default.
- W2791448816 citedByCount "34" @default.
- W2791448816 countsByYear W27914488162018 @default.
- W2791448816 countsByYear W27914488162019 @default.
- W2791448816 countsByYear W27914488162020 @default.
- W2791448816 countsByYear W27914488162021 @default.
- W2791448816 countsByYear W27914488162022 @default.
- W2791448816 countsByYear W27914488162023 @default.
- W2791448816 crossrefType "journal-article" @default.
- W2791448816 hasAuthorship W2791448816A5000341131 @default.
- W2791448816 hasAuthorship W2791448816A5009263498 @default.
- W2791448816 hasAuthorship W2791448816A5029246125 @default.
- W2791448816 hasAuthorship W2791448816A5044752020 @default.
- W2791448816 hasAuthorship W2791448816A5052323062 @default.
- W2791448816 hasAuthorship W2791448816A5088477455 @default.
- W2791448816 hasAuthorship W2791448816A5090739101 @default.
- W2791448816 hasBestOaLocation W27914488161 @default.
- W2791448816 hasConcept C104317684 @default.
- W2791448816 hasConcept C107538193 @default.
- W2791448816 hasConcept C150194340 @default.
- W2791448816 hasConcept C153911025 @default.
- W2791448816 hasConcept C177504595 @default.
- W2791448816 hasConcept C2777216303 @default.
- W2791448816 hasConcept C2777658100 @default.
- W2791448816 hasConcept C2779688582 @default.
- W2791448816 hasConcept C2779769559 @default.
- W2791448816 hasConcept C502942594 @default.