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- W2791459291 abstract "Background Butylparaben (butyl p‐hydroxybenzoic acid) is a common cosmetic and pharmaceutical preservative reported to induce oxidative stress and endocrine disruption. Embryonic development is sensitive to oxidative stress, with redox potentials playing critical roles in progenitor cell fate decisions. Because pancreatic beta cells have been reported to have low antioxidant gene expression, they may be sensitive targets of oxidative stress. We tested the hypotheses that butylparaben causes oxidative stress in the developing embryo, and that pancreatic beta cells are a sensitive target of butylparaben embryotoxicity. Methods Transgenic insulin:GFP zebrafish embryos ( Danio rerio) were treated daily with 0, 250, 500, 1,000, and 3,000 nM butylparaben. Pancreatic islet and whole embryo development were examined though 7 days postfertilization, and gene expression was measured by quantitative real‐time PCR. Glutathione (GSH) and cysteine redox content were measured at 28 hr postfertilization using HPLC. Results Butylparaben exposure caused intestinal effusion, pericardial edema, and accelerated yolk utilization. At 250 nM, beta cell area increased by as much as 55%, and increased incidence of two aberrant morphologies were observed‐fragmentation of the islet cluster and ectopic beta cells. Butylparaben concentrations of 500 and 1,000 nM increased GSH by 10 and 40%, respectively. Butylparaben exposure downregulated transcription factor pdx1 , as well as genes involved in GSH synthesis, while upregulating GSH‐disulfide reductase ( gsr ). Conclusions The endocrine pancreas is a sensitive target of embryonic exposure to butylparaben, which also causes developmental deformities and perturbs redox conditions in the embryo." @default.
- W2791459291 created "2018-03-29" @default.
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- W2791459291 date "2018-03-08" @default.
- W2791459291 modified "2023-10-14" @default.
- W2791459291 title "Pancreatic beta cells are a sensitive target of embryonic exposure to butylparaben in zebrafish (<i>Danio rerio</i>)" @default.
- W2791459291 cites W155491122 @default.
- W2791459291 cites W1581565952 @default.
- W2791459291 cites W1784042654 @default.
- W2791459291 cites W1845508194 @default.
- W2791459291 cites W188349884 @default.
- W2791459291 cites W1945129107 @default.
- W2791459291 cites W1966023977 @default.
- W2791459291 cites W1970240791 @default.
- W2791459291 cites W1971383450 @default.
- W2791459291 cites W1972155677 @default.
- W2791459291 cites W1973219362 @default.
- W2791459291 cites W1978172411 @default.
- W2791459291 cites W1979841620 @default.
- W2791459291 cites W1979849644 @default.
- W2791459291 cites W1985350316 @default.
- W2791459291 cites W1988786743 @default.
- W2791459291 cites W1989429411 @default.
- W2791459291 cites W1991694614 @default.
- W2791459291 cites W1992731733 @default.
- W2791459291 cites W1996478622 @default.
- W2791459291 cites W1998738230 @default.
- W2791459291 cites W2010086727 @default.
- W2791459291 cites W2010290591 @default.
- W2791459291 cites W2010492205 @default.
- W2791459291 cites W2012749977 @default.
- W2791459291 cites W2013444832 @default.
- W2791459291 cites W2017237442 @default.
- W2791459291 cites W2025437114 @default.
- W2791459291 cites W2028465517 @default.
- W2791459291 cites W2028958360 @default.
- W2791459291 cites W2028991058 @default.
- W2791459291 cites W2031935406 @default.
- W2791459291 cites W2032789267 @default.
- W2791459291 cites W2038245668 @default.
- W2791459291 cites W2044504073 @default.
- W2791459291 cites W2050610995 @default.
- W2791459291 cites W2051502375 @default.
- W2791459291 cites W2062120702 @default.
- W2791459291 cites W2064197222 @default.
- W2791459291 cites W2073760162 @default.
- W2791459291 cites W2083849360 @default.
- W2791459291 cites W2087235211 @default.
- W2791459291 cites W2091490477 @default.
- W2791459291 cites W2092915416 @default.
- W2791459291 cites W2095466273 @default.
- W2791459291 cites W2107277218 @default.
- W2791459291 cites W2120543755 @default.
- W2791459291 cites W2123498365 @default.
- W2791459291 cites W2133396420 @default.
- W2791459291 cites W2134839098 @default.
- W2791459291 cites W2142167067 @default.
- W2791459291 cites W2152698789 @default.
- W2791459291 cites W2155017486 @default.
- W2791459291 cites W2156044622 @default.
- W2791459291 cites W2157579468 @default.
- W2791459291 cites W2171603493 @default.
- W2791459291 cites W2192080449 @default.
- W2791459291 cites W2274541849 @default.
- W2791459291 cites W2283963177 @default.
- W2791459291 cites W2342567805 @default.
- W2791459291 cites W2394083311 @default.
- W2791459291 cites W244889029 @default.
- W2791459291 cites W2470900752 @default.
- W2791459291 cites W2512654216 @default.
- W2791459291 cites W2543456225 @default.
- W2791459291 cites W2615006438 @default.
- W2791459291 cites W2771361134 @default.
- W2791459291 cites W3027612327 @default.
- W2791459291 cites W4211098409 @default.
- W2791459291 doi "https://doi.org/10.1002/bdr2.1215" @default.
- W2791459291 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6030486" @default.
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- W2791459291 hasPublicationYear "2018" @default.
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