Matches in SemOpenAlex for { <https://semopenalex.org/work/W2791465814> ?p ?o ?g. }
- W2791465814 endingPage "119" @default.
- W2791465814 startingPage "108" @default.
- W2791465814 abstract "Voltage-dependent calcium channels (VDCC) have been shown to regulate neuronal excitability and their antagonists have been used clinically for the control of seizures. While functional studies of VDCC in epileptogenesis in the CA1 area of hippocampus or the dentate gyrus have been done, few studies were carried out in the CA3 area. Given the bursting characteristics of the CA3 neurons, we speculated that VDCC in the CA3 area might play an important role in the epileptogenesis. In the present study in the mouse pilocarpine model of temporal lobe epilepsy, we investigated the alterations of alpha 1 subunits of L-type VDCC in the CA3 area of the hippocampus at different stages of epileptogenesis, i.e., acute stage from 10 min to 1 day during and after pilocapine-induced status epilepticus (SE), latent period at 1 week, and chronic stage with spontaneous recurrent seizures at 2 months after SE. We found that an immediate redistribution of alpha 1 subunits in the CA3 area occurred during SE which might be involved in the seizure occurrence indicated by the Racine score record. Alterations of alpha 1 subunits were also demonstrated in the latent period and chronic stage, which might be related to the epileptogenesis and occurrence of epilepsy. Cav1.3, but not Cav1.2, was expressed in reactive astrocytes of the CA3 area, indicating the involvement of Cav1.3 in the modulation of astrocytic Ca2+ homeostasis during epileptogenesis." @default.
- W2791465814 created "2018-03-29" @default.
- W2791465814 creator A5049258884 @default.
- W2791465814 creator A5049407127 @default.
- W2791465814 creator A5053511146 @default.
- W2791465814 creator A5077657420 @default.
- W2791465814 date "2018-03-01" @default.
- W2791465814 modified "2023-10-13" @default.
- W2791465814 title "Alterations of L-type voltage dependent calcium channel alpha 1 subunit in the hippocampal CA3 region during and after pilocarpine-induced epilepsy" @default.
- W2791465814 cites W1468596969 @default.
- W2791465814 cites W1505475872 @default.
- W2791465814 cites W1513345777 @default.
- W2791465814 cites W1543942926 @default.
- W2791465814 cites W1617355594 @default.
- W2791465814 cites W1963574467 @default.
- W2791465814 cites W1963711426 @default.
- W2791465814 cites W1964474060 @default.
- W2791465814 cites W1968118531 @default.
- W2791465814 cites W1970222424 @default.
- W2791465814 cites W1970602512 @default.
- W2791465814 cites W1971959365 @default.
- W2791465814 cites W1975555279 @default.
- W2791465814 cites W1975776821 @default.
- W2791465814 cites W1975871230 @default.
- W2791465814 cites W1979203900 @default.
- W2791465814 cites W1979482847 @default.
- W2791465814 cites W1979848898 @default.
- W2791465814 cites W1982938174 @default.
- W2791465814 cites W1983100194 @default.
- W2791465814 cites W1984213418 @default.
- W2791465814 cites W1987398739 @default.
- W2791465814 cites W1989033459 @default.
- W2791465814 cites W1992082068 @default.
- W2791465814 cites W1994366463 @default.
- W2791465814 cites W1997427652 @default.
- W2791465814 cites W1999319139 @default.
- W2791465814 cites W2000948750 @default.
- W2791465814 cites W2001730079 @default.
- W2791465814 cites W2002212240 @default.
- W2791465814 cites W2002865741 @default.
- W2791465814 cites W2005342574 @default.
- W2791465814 cites W2006200262 @default.
- W2791465814 cites W2013363962 @default.
- W2791465814 cites W2014292589 @default.
- W2791465814 cites W2015285707 @default.
- W2791465814 cites W2028772150 @default.
- W2791465814 cites W2032255062 @default.
- W2791465814 cites W2034041490 @default.
- W2791465814 cites W2036196548 @default.
- W2791465814 cites W2037100068 @default.
- W2791465814 cites W2040109036 @default.
- W2791465814 cites W2042469463 @default.
- W2791465814 cites W2045945377 @default.
- W2791465814 cites W2048621600 @default.
- W2791465814 cites W2060552473 @default.
- W2791465814 cites W2061453438 @default.
- W2791465814 cites W2062548772 @default.
- W2791465814 cites W2063807479 @default.
- W2791465814 cites W2067515894 @default.
- W2791465814 cites W2070993564 @default.
- W2791465814 cites W2073885975 @default.
- W2791465814 cites W2075869459 @default.
- W2791465814 cites W2076923772 @default.
- W2791465814 cites W2076930890 @default.
- W2791465814 cites W2082099156 @default.
- W2791465814 cites W2090157435 @default.
- W2791465814 cites W2096961422 @default.
- W2791465814 cites W2104417933 @default.
- W2791465814 cites W2107938778 @default.
- W2791465814 cites W2111493144 @default.
- W2791465814 cites W2111547035 @default.
- W2791465814 cites W2120587186 @default.
- W2791465814 cites W2129404230 @default.
- W2791465814 cites W2131306660 @default.
- W2791465814 cites W2133346716 @default.
- W2791465814 cites W2135328571 @default.
- W2791465814 cites W2137985966 @default.
- W2791465814 cites W2141989757 @default.
- W2791465814 cites W2142377896 @default.
- W2791465814 cites W2145517203 @default.
- W2791465814 cites W2150224475 @default.
- W2791465814 cites W2152361386 @default.
- W2791465814 cites W2152904049 @default.
- W2791465814 cites W2154905702 @default.
- W2791465814 cites W2156094132 @default.
- W2791465814 cites W2164136145 @default.
- W2791465814 cites W2167441016 @default.
- W2791465814 cites W2329244491 @default.
- W2791465814 cites W2472129423 @default.
- W2791465814 cites W2592622036 @default.
- W2791465814 cites W4322703181 @default.
- W2791465814 cites W780198943 @default.
- W2791465814 doi "https://doi.org/10.1016/j.neuint.2018.02.005" @default.
- W2791465814 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29425964" @default.
- W2791465814 hasPublicationYear "2018" @default.
- W2791465814 type Work @default.
- W2791465814 sameAs 2791465814 @default.
- W2791465814 citedByCount "4" @default.