Matches in SemOpenAlex for { <https://semopenalex.org/work/W2791469557> ?p ?o ?g. }
- W2791469557 endingPage "349" @default.
- W2791469557 startingPage "341" @default.
- W2791469557 abstract "ObjectiveTo investigate the role of HELQ in chemo-resistance of epithelial ovarian carcinoma (EOC), which is a critical factor of patients' prognosis.MethodsImmunohistochemistry, survival analysis of our 87 EOC patients and bioinformatics analysis of The Cancer Genome Atlas (TCGA) datasets (Nature, 2011) disclosed the clinical importance of HELQ expression. Quantitative reverse transcription polymerase chain reaction (qRT-PCR), and Western Blot analyses of EOC tissue were used to confirm it. Ectopic overexpression and RNA interference knockdown of HELQ were carried out in OVCAR3 and A2780 cell lines, respectively, to determine the effect of altered HELQ expression on cellular response to cisplatin by CCK8 assay. The DNA repair capacity of these cells was evaluated by using host-cell reactivation assay. Western Blot analyses were carried out to determine the effect of HLEQ on the DNA repair genes by using cells with altered HELQ expression.ResultsHELQ expression associates with response of EOC patients to platinum-based chemotherapy and their overall survival (OS), disease free survival (DFS). HELQ overexpression or knockdown, respectively, increased and decreased the cellular resistance to cisplatin, DNA repair activity, and expression of DNA repair proteins of Nucleotide excision repair (NER) pathway.ConclusionsHELQ plays an important role in regulating the expression of DNA repair proteins NER pathway which, in turn, contributes to cellular response to cisplatin and patients' response to platinum-based chemotherapy. Our results demonstrated that HELQ could serve as a novel indicator for chemo-resistance of EOC, which can predict the prognosis of the disease." @default.
- W2791469557 created "2018-03-29" @default.
- W2791469557 creator A5002608004 @default.
- W2791469557 creator A5009616306 @default.
- W2791469557 creator A5017338377 @default.
- W2791469557 creator A5023644903 @default.
- W2791469557 creator A5034980717 @default.
- W2791469557 creator A5036392650 @default.
- W2791469557 creator A5050318036 @default.
- W2791469557 creator A5052364380 @default.
- W2791469557 creator A5054930410 @default.
- W2791469557 creator A5081497081 @default.
- W2791469557 creator A5085788510 @default.
- W2791469557 date "2018-05-01" @default.
- W2791469557 modified "2023-10-16" @default.
- W2791469557 title "Helicase POLQ-like (HELQ) as a novel indicator of platinum-based chemoresistance for epithelial ovarian cancer" @default.
- W2791469557 cites W145577621 @default.
- W2791469557 cites W1928092242 @default.
- W2791469557 cites W1961406038 @default.
- W2791469557 cites W1961928411 @default.
- W2791469557 cites W1963835874 @default.
- W2791469557 cites W1973268287 @default.
- W2791469557 cites W1980750512 @default.
- W2791469557 cites W1999659306 @default.
- W2791469557 cites W2009007206 @default.
- W2791469557 cites W2009733058 @default.
- W2791469557 cites W2015969693 @default.
- W2791469557 cites W2018588892 @default.
- W2791469557 cites W2029893817 @default.
- W2791469557 cites W2033384149 @default.
- W2791469557 cites W2065071195 @default.
- W2791469557 cites W2073641425 @default.
- W2791469557 cites W2076951953 @default.
- W2791469557 cites W2082054147 @default.
- W2791469557 cites W2092160717 @default.
- W2791469557 cites W2110017381 @default.
- W2791469557 cites W2123696077 @default.
- W2791469557 cites W2142658272 @default.
- W2791469557 cites W2151509048 @default.
- W2791469557 cites W2155768425 @default.
- W2791469557 cites W2159501858 @default.
- W2791469557 cites W2160466424 @default.
- W2791469557 cites W2163885210 @default.
- W2791469557 cites W2164039780 @default.
- W2791469557 cites W2165308870 @default.
- W2791469557 cites W2169402189 @default.
- W2791469557 cites W2170454539 @default.
- W2791469557 cites W2171972386 @default.
- W2791469557 cites W2176338880 @default.
- W2791469557 cites W2346330623 @default.
- W2791469557 cites W2507252751 @default.
- W2791469557 cites W2528228811 @default.
- W2791469557 cites W2529744076 @default.
- W2791469557 cites W2570618306 @default.
- W2791469557 doi "https://doi.org/10.1016/j.ygyno.2018.03.006" @default.
- W2791469557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29572031" @default.
- W2791469557 hasPublicationYear "2018" @default.
- W2791469557 type Work @default.
- W2791469557 sameAs 2791469557 @default.
- W2791469557 citedByCount "10" @default.
- W2791469557 countsByYear W27914695572018 @default.
- W2791469557 countsByYear W27914695572019 @default.
- W2791469557 countsByYear W27914695572020 @default.
- W2791469557 countsByYear W27914695572021 @default.
- W2791469557 countsByYear W27914695572022 @default.
- W2791469557 countsByYear W27914695572023 @default.
- W2791469557 crossrefType "journal-article" @default.
- W2791469557 hasAuthorship W2791469557A5002608004 @default.
- W2791469557 hasAuthorship W2791469557A5009616306 @default.
- W2791469557 hasAuthorship W2791469557A5017338377 @default.
- W2791469557 hasAuthorship W2791469557A5023644903 @default.
- W2791469557 hasAuthorship W2791469557A5034980717 @default.
- W2791469557 hasAuthorship W2791469557A5036392650 @default.
- W2791469557 hasAuthorship W2791469557A5050318036 @default.
- W2791469557 hasAuthorship W2791469557A5052364380 @default.
- W2791469557 hasAuthorship W2791469557A5054930410 @default.
- W2791469557 hasAuthorship W2791469557A5081497081 @default.
- W2791469557 hasAuthorship W2791469557A5085788510 @default.
- W2791469557 hasBestOaLocation W27914695571 @default.
- W2791469557 hasConcept C104317684 @default.
- W2791469557 hasConcept C121608353 @default.
- W2791469557 hasConcept C126322002 @default.
- W2791469557 hasConcept C134935766 @default.
- W2791469557 hasConcept C143425029 @default.
- W2791469557 hasConcept C153911025 @default.
- W2791469557 hasConcept C173396325 @default.
- W2791469557 hasConcept C190283241 @default.
- W2791469557 hasConcept C2776415932 @default.
- W2791469557 hasConcept C2776694085 @default.
- W2791469557 hasConcept C2778239845 @default.
- W2791469557 hasConcept C2780427987 @default.
- W2791469557 hasConcept C502942594 @default.
- W2791469557 hasConcept C54355233 @default.
- W2791469557 hasConcept C552990157 @default.
- W2791469557 hasConcept C71924100 @default.
- W2791469557 hasConcept C81885089 @default.
- W2791469557 hasConcept C86803240 @default.
- W2791469557 hasConcept C97037327 @default.