Matches in SemOpenAlex for { <https://semopenalex.org/work/W2791471567> ?p ?o ?g. }
- W2791471567 abstract "Evolutionary analysis of cis-regulatory DNA reveals that enhancers consist of clusters of conserved sequence blocks (CSBs) that are made up of both unique and repeated sequence elements. This study seeks to address the basis for spatial and temporal regulation of neuroblas. A search for temporally restricted CNS NB enhancers identified one within the transcription factor grainyhead (grh) gene locus. The intronic enhancer, grh-15, contains two separable semi-autonomous activities, one that drives expression predominantly within the developing brain NBs and another in ventral cord NBs. To gain insight into the function of the CSBs constituting the brain-specific enhancer, we have systematically deleted each CSB and compared the activity of the altered enhancer to that of the full brain-specific enhancer. While our results indicate that information regulating enhancer activity is highly redundant, we have found that individual CSBs convey expression in subsets of larval lineages that are generated from either Type I or Type II NBs. These studies also highlight how evolutionary sequence conservation can be used as a guide the functional analysis of cis-regulatory DNA." @default.
- W2791471567 created "2018-03-29" @default.
- W2791471567 creator A5056788317 @default.
- W2791471567 creator A5059139451 @default.
- W2791471567 creator A5069439820 @default.
- W2791471567 creator A5082072091 @default.
- W2791471567 date "2018-03-01" @default.
- W2791471567 modified "2023-09-23" @default.
- W2791471567 title "Structure and<i>cis</i>-regulatory analysis of a<i>Drosophila grainyhead</i>neuroblast enhancer" @default.
- W2791471567 cites W121396268 @default.
- W2791471567 cites W1596151316 @default.
- W2791471567 cites W1921203043 @default.
- W2791471567 cites W1981336776 @default.
- W2791471567 cites W1985922092 @default.
- W2791471567 cites W1988488815 @default.
- W2791471567 cites W1991777044 @default.
- W2791471567 cites W1996364691 @default.
- W2791471567 cites W2004103307 @default.
- W2791471567 cites W2011868306 @default.
- W2791471567 cites W2012118125 @default.
- W2791471567 cites W2020503755 @default.
- W2791471567 cites W2026833123 @default.
- W2791471567 cites W2026998481 @default.
- W2791471567 cites W2032247729 @default.
- W2791471567 cites W2037611829 @default.
- W2791471567 cites W2041379765 @default.
- W2791471567 cites W2045362835 @default.
- W2791471567 cites W204955802 @default.
- W2791471567 cites W2059263766 @default.
- W2791471567 cites W2061802413 @default.
- W2791471567 cites W2061912426 @default.
- W2791471567 cites W2065770077 @default.
- W2791471567 cites W2071439845 @default.
- W2791471567 cites W2082670705 @default.
- W2791471567 cites W2083852770 @default.
- W2791471567 cites W2090435424 @default.
- W2791471567 cites W2096060868 @default.
- W2791471567 cites W2104582907 @default.
- W2791471567 cites W2107227145 @default.
- W2791471567 cites W2113519429 @default.
- W2791471567 cites W2127605595 @default.
- W2791471567 cites W2128770658 @default.
- W2791471567 cites W2137718411 @default.
- W2791471567 cites W2138771990 @default.
- W2791471567 cites W2153017169 @default.
- W2791471567 cites W2158092584 @default.
- W2791471567 cites W2161396457 @default.
- W2791471567 cites W2163554076 @default.
- W2791471567 cites W2169062325 @default.
- W2791471567 cites W2214376646 @default.
- W2791471567 cites W2219121912 @default.
- W2791471567 cites W231822359 @default.
- W2791471567 cites W2515589436 @default.
- W2791471567 cites W2554961135 @default.
- W2791471567 cites W2567174107 @default.
- W2791471567 cites W2578258684 @default.
- W2791471567 cites W2579394006 @default.
- W2791471567 cites W4236521732 @default.
- W2791471567 doi "https://doi.org/10.1002/dvg.23094" @default.
- W2791471567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29417712" @default.
- W2791471567 hasPublicationYear "2018" @default.
- W2791471567 type Work @default.
- W2791471567 sameAs 2791471567 @default.
- W2791471567 citedByCount "2" @default.
- W2791471567 countsByYear W27914715672018 @default.
- W2791471567 countsByYear W27914715672019 @default.
- W2791471567 crossrefType "journal-article" @default.
- W2791471567 hasAuthorship W2791471567A5056788317 @default.
- W2791471567 hasAuthorship W2791471567A5059139451 @default.
- W2791471567 hasAuthorship W2791471567A5069439820 @default.
- W2791471567 hasAuthorship W2791471567A5082072091 @default.
- W2791471567 hasConcept C104317684 @default.
- W2791471567 hasConcept C111936080 @default.
- W2791471567 hasConcept C143211211 @default.
- W2791471567 hasConcept C199216141 @default.
- W2791471567 hasConcept C21592294 @default.
- W2791471567 hasConcept C21784809 @default.
- W2791471567 hasConcept C3017666073 @default.
- W2791471567 hasConcept C39961270 @default.
- W2791471567 hasConcept C4746552 @default.
- W2791471567 hasConcept C54355233 @default.
- W2791471567 hasConcept C84597430 @default.
- W2791471567 hasConcept C86339819 @default.
- W2791471567 hasConcept C86803240 @default.
- W2791471567 hasConceptScore W2791471567C104317684 @default.
- W2791471567 hasConceptScore W2791471567C111936080 @default.
- W2791471567 hasConceptScore W2791471567C143211211 @default.
- W2791471567 hasConceptScore W2791471567C199216141 @default.
- W2791471567 hasConceptScore W2791471567C21592294 @default.
- W2791471567 hasConceptScore W2791471567C21784809 @default.
- W2791471567 hasConceptScore W2791471567C3017666073 @default.
- W2791471567 hasConceptScore W2791471567C39961270 @default.
- W2791471567 hasConceptScore W2791471567C4746552 @default.
- W2791471567 hasConceptScore W2791471567C54355233 @default.
- W2791471567 hasConceptScore W2791471567C84597430 @default.
- W2791471567 hasConceptScore W2791471567C86339819 @default.
- W2791471567 hasConceptScore W2791471567C86803240 @default.
- W2791471567 hasIssue "3" @default.
- W2791471567 hasLocation W27914715671 @default.
- W2791471567 hasLocation W27914715672 @default.